ID SGK1_CHICK Reviewed; 432 AA.
AC Q6U1I9;
DT 28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 126.
DE RecName: Full=Serine/threonine-protein kinase Sgk1;
DE EC=2.7.11.1;
DE AltName: Full=Serum/glucocorticoid-regulated kinase 1;
GN Name=SGK1; Synonyms=SGK;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Malkiewicz S.A., Porter T.E.;
RT "Sgk is a glucocorticoid-induced gene in the chicken embryonic pituitary
RT gland.";
RL Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Protein kinase that may play an important role in cellular
CC stress response. May be involved in the regulation of processes such as
CC cell survival, neuronal excitability and renal sodium excretion (By
CC similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC Endoplasmic reticulum {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. AGC Ser/Thr
CC protein kinase family. {ECO:0000305}.
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DR EMBL; AY380825; AAQ88435.1; -; mRNA.
DR RefSeq; NP_989807.1; NM_204476.1.
DR AlphaFoldDB; Q6U1I9; -.
DR SMR; Q6U1I9; -.
DR STRING; 9031.ENSGALP00000068769; -.
DR PaxDb; 9031-ENSGALP00000031130; -.
DR Ensembl; ENSGALT00000031766; ENSGALP00000031130; ENSGALG00000013971.
DR Ensembl; ENSGALT00010015194.1; ENSGALP00010008927.1; ENSGALG00010006359.1.
DR Ensembl; ENSGALT00015010227; ENSGALP00015005621; ENSGALG00015004366.
DR GeneID; 395133; -.
DR KEGG; gga:395133; -.
DR CTD; 6446; -.
DR VEuPathDB; HostDB:geneid_395133; -.
DR eggNOG; KOG0598; Eukaryota.
DR GeneTree; ENSGT00940000155726; -.
DR HOGENOM; CLU_000288_63_5_1; -.
DR InParanoid; Q6U1I9; -.
DR OrthoDB; 3028764at2759; -.
DR PhylomeDB; Q6U1I9; -.
DR TreeFam; TF320906; -.
DR Reactome; R-GGA-1257604; PIP3 activates AKT signaling.
DR Reactome; R-GGA-2672351; Stimuli-sensing channels.
DR Reactome; R-GGA-6804757; Regulation of TP53 Degradation.
DR Reactome; R-GGA-9031628; NGF-stimulated transcription.
DR PRO; PR:Q6U1I9; -.
DR Proteomes; UP000000539; Chromosome 3.
DR Bgee; ENSGALG00000013971; Expressed in lung and 13 other cell types or tissues.
DR ExpressionAtlas; Q6U1I9; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0015459; F:potassium channel regulator activity; IBA:GO_Central.
DR GO; GO:0106310; F:protein serine kinase activity; IEA:RHEA.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IBA:GO_Central.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0035556; P:intracellular signal transduction; IBA:GO_Central.
DR GO; GO:0048812; P:neuron projection morphogenesis; IBA:GO_Central.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05575; STKc_SGK; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR000961; AGC-kinase_C.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR017892; Pkinase_C.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR24351; RIBOSOMAL PROTEIN S6 KINASE; 1.
DR PANTHER; PTHR24351:SF184; SERINE_THREONINE-PROTEIN KINASE SGK1; 1.
DR Pfam; PF00069; Pkinase; 1.
DR Pfam; PF00433; Pkinase_C; 1.
DR SMART; SM00133; S_TK_X; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51285; AGC_KINASE_CTER; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 2: Evidence at transcript level;
KW Apoptosis; ATP-binding; Cytoplasm; Endoplasmic reticulum; Kinase;
KW Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome;
KW Serine/threonine-protein kinase; Stress response; Transferase.
FT CHAIN 1..432
FT /note="Serine/threonine-protein kinase Sgk1"
FT /id="PRO_0000380130"
FT DOMAIN 99..356
FT /note="Protein kinase"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT DOMAIN 357..432
FT /note="AGC-kinase C-terminal"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00618"
FT REGION 67..93
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 223
FT /note="Proton acceptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159,
FT ECO:0000255|PROSITE-ProRule:PRU10027"
FT BINDING 105..113
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT BINDING 128
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
SQ SEQUENCE 432 AA; 48890 MW; 83AB52AFF2609953 CRC64;
MTVKAAEASG PALTYSKMRG MVAILIAFMK QRRMGLNDFI QKIATNSYAC KHPEVQSILK
ISQPQEPELM NANPSPPPSP SQQINLGPSS NPHAKPSDFH FLKVIGKGSF GKVLLARHKA
EEQFYAVKVL QKKAILKKKE EKHIMSERNV LLKNVKHPFL VGLHFSFQTA DKLYFVLDYI
NGGELFYHLQ RERCFLEPRA RFYAAEIASA LGYLHSLNIV YRDLKPENIL LDSQGHIVLT
DFGLCKENIE HNGTTSTFCG TPEYLAPEVL HKQPYDRTVD WWCLGAVLYE MLYGLPPFYS
RNTAEMYDNI LNKPLQLKPN ITNSARHLLE GLLQKDRTKR LGAKEDFTEI KNHIFFSPIN
WDDLINKKIT PPFNPNVSGP SDLRHFDPEF TDEPVPNSIG QSPDSILITA SVKEAAEAFL
GFSYAPPVDS FL
//
