ID SIKE1_XENTR Reviewed; 207 AA.
AC Q5I033;
DT 21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT 15-FEB-2005, sequence version 1.
DT 27-MAR-2024, entry version 83.
DE RecName: Full=Suppressor of IKBKE 1;
DE AltName: Full=Suppressor of IKK-epsilon;
GN Name=sike1; Synonyms=sike; ORFNames=TTpA011e05.1;
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Tadpole;
RG Sanger Xenopus tropicalis EST/cDNA project;
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Suppressor of IKK-epsilon. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SIKE family. {ECO:0000305}.
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DR EMBL; CR848255; CAJ83158.1; -; mRNA.
DR EMBL; BC088764; AAH88764.1; -; mRNA.
DR RefSeq; NP_001011474.1; NM_001011474.1.
DR RefSeq; XP_012816905.1; XM_012961451.1.
DR AlphaFoldDB; Q5I033; -.
DR SMR; Q5I033; -.
DR STRING; 8364.ENSXETP00000033339; -.
DR PaxDb; 8364-ENSXETP00000046368; -.
DR DNASU; 496965; -.
DR GeneID; 496965; -.
DR KEGG; xtr:496965; -.
DR AGR; Xenbase:XB-GENE-1003385; -.
DR CTD; 80143; -.
DR Xenbase; XB-GENE-1003385; sike1.
DR eggNOG; ENOG502QTKS; Eukaryota.
DR HOGENOM; CLU_073167_1_0_1; -.
DR InParanoid; Q5I033; -.
DR OMA; QLVMQKH; -.
DR OrthoDB; 5396923at2759; -.
DR TreeFam; TF324337; -.
DR Proteomes; UP000008143; Chromosome 2.
DR Bgee; ENSXETG00000021446; Expressed in ovary and 14 other cell types or tissues.
DR ExpressionAtlas; Q5I033; differential.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR InterPro; IPR008555; SIKE.
DR PANTHER; PTHR12186; SIKE FAMILY MEMBER; 1.
DR PANTHER; PTHR12186:SF4; SUPPRESSOR OF IKBKE 1; 1.
DR Pfam; PF05769; SIKE; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Cytoplasm; Reference proteome.
FT CHAIN 1..207
FT /note="Suppressor of IKBKE 1"
FT /id="PRO_0000299056"
FT REGION 186..207
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 4..32
FT /evidence="ECO:0000255"
FT COILED 154..193
FT /evidence="ECO:0000255"
SQ SEQUENCE 207 AA; 23997 MW; 4B4B7AD69ED14C0D CRC64;
MTCTIDKILQ DAKTLLERLK DHDNAAESLI DQSSALHKRV EAMKEVGTAM PEKYQEELAD
IKDASKLKPH VLLCQENTQI RDLQQENKEL WVSLEEHQYA LELIMSKYRK QMLQLVANKK
PAPTEPVLEA HKTFSSDLEC QIDRICVMGD IMRDAIQLDE DKAYNIQEKL AQLELENKEL
REILSTSKES LHSSKRESEW NFSEKTQ
//
