ID SMTA_CHLAA Reviewed; 455 AA.
AC A9WC40;
DT 09-JUL-2014, integrated into UniProtKB/Swiss-Prot.
DT 05-FEB-2008, sequence version 1.
DT 27-MAR-2024, entry version 76.
DE RecName: Full=Succinyl-CoA--L-malate CoA-transferase alpha subunit;
DE EC=2.8.3.22;
GN Name=smtA; OrderedLocusNames=Caur_0179;
OS Chloroflexus aurantiacus (strain ATCC 29366 / DSM 635 / J-10-fl).
OC Bacteria; Chloroflexota; Chloroflexia; Chloroflexales; Chloroflexineae;
OC Chloroflexaceae; Chloroflexus.
OX NCBI_TaxID=324602;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 29366 / DSM 635 / J-10-fl;
RX PubMed=21714912; DOI=10.1186/1471-2164-12-334;
RA Tang K.H., Barry K., Chertkov O., Dalin E., Han C.S., Hauser L.J.,
RA Honchak B.M., Karbach L.E., Land M.L., Lapidus A., Larimer F.W.,
RA Mikhailova N., Pitluck S., Pierson B.K., Blankenship R.E.;
RT "Complete genome sequence of the filamentous anoxygenic phototrophic
RT bacterium Chloroflexus aurantiacus.";
RL BMC Genomics 12:334-334(2011).
CC -!- FUNCTION: Involved in the 3-hydroxypropionate cycle used for
CC autotrophic carbon dioxide fixation. Catalyzes the transfer of CoA
CC moiety from succinyl-CoA to L-malate to yield L-malyl-CoA (By
CC similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(S)-malate + succinyl-CoA = (S)-malyl-CoA + succinate;
CC Xref=Rhea:RHEA:38255, ChEBI:CHEBI:15589, ChEBI:CHEBI:30031,
CC ChEBI:CHEBI:57292, ChEBI:CHEBI:57317; EC=2.8.3.22;
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(3S)-citramalate + succinyl-CoA = (3S)-citramalyl-CoA +
CC succinate; Xref=Rhea:RHEA:38287, ChEBI:CHEBI:30031,
CC ChEBI:CHEBI:30936, ChEBI:CHEBI:57292, ChEBI:CHEBI:58668; EC=2.8.3.22;
CC -!- SUBUNIT: Forms a large complex composed of six heterodimers (alpha,
CC beta). {ECO:0000250}.
CC -!- INDUCTION: Under autotrophic growth conditions. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the CoA-transferase III family. {ECO:0000305}.
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DR EMBL; CP000909; ABY33433.1; -; Genomic_DNA.
DR RefSeq; WP_012256089.1; NC_010175.1.
DR RefSeq; YP_001633822.1; NC_010175.1.
DR AlphaFoldDB; A9WC40; -.
DR SMR; A9WC40; -.
DR STRING; 324602.Caur_0179; -.
DR EnsemblBacteria; ABY33433; ABY33433; Caur_0179.
DR KEGG; cau:Caur_0179; -.
DR PATRIC; fig|324602.8.peg.208; -.
DR eggNOG; COG1804; Bacteria.
DR HOGENOM; CLU_033975_2_0_0; -.
DR InParanoid; A9WC40; -.
DR BioCyc; MetaCyc:MONOMER-13599; -.
DR Proteomes; UP000002008; Chromosome.
DR GO; GO:0008410; F:CoA-transferase activity; ISS:UniProtKB.
DR GO; GO:0047370; F:succinate-citramalate CoA-transferase activity; IEA:RHEA.
DR GO; GO:0043427; P:carbon fixation by 3-hydroxypropionate cycle; ISS:UniProtKB.
DR Gene3D; 3.30.1540.10; formyl-coa transferase, domain 3; 1.
DR InterPro; IPR003673; CoA-Trfase_fam_III.
DR InterPro; IPR044855; CoA-Trfase_III_dom3_sf.
DR InterPro; IPR023606; CoA-Trfase_III_dom_1_sf.
DR PANTHER; PTHR48228:SF6; L-CARNITINE COA-TRANSFERASE; 1.
DR PANTHER; PTHR48228; SUCCINYL-COA--D-CITRAMALATE COA-TRANSFERASE; 1.
DR Pfam; PF02515; CoA_transf_3; 1.
DR SUPFAM; SSF89796; CoA-transferase family III (CaiB/BaiF); 1.
PE 3: Inferred from homology;
KW Carbon dioxide fixation; Reference proteome; Transferase.
FT CHAIN 1..455
FT /note="Succinyl-CoA--L-malate CoA-transferase alpha
FT subunit"
FT /id="PRO_0000429592"
FT REGION 1..58
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..30
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 227
FT /note="Nucleophile"
FT /evidence="ECO:0000250"
SQ SEQUENCE 455 AA; 49514 MW; 02E3785CFACC9A21 CRC64;
MAKASRLTRS TGQPTEVSEG QVTGTSEMPP TGEEPSGHAE SKPPASDPMS TPGTGQEQLP
LSGIRVIDVG NFLAGPYAAS ILGEFGAEVL KIEHPLGGDP MRRFGTATAR HDATLAWLSE
ARNRKSVTID LRQQEGVALF LKLVAKSDIL IENFRPGTME EWGLSWPVLQ ATNPGLIMLR
VSGYGQTGPY RRRSGFAHIA HAFSGLSYLA GFPGETPVLP GTAPLGDYIA SLFGAIGILI
ALRHKEQTGR GQLIDVGIYE AVFRILDEIA PAYGLFGKIR EREGAGSFIA VPHGHFRSKD
GKWVAIACTT DKMFERLAEA MERPELASPE LYGDQRKRLA ARDIVNQITI EWVGSLTRDE
VMRRCLEKEV PVGPLNSIAD MFNDEHFLAR GNFACIEAEG IGEVVVPNVI PRLSETPGRV
TNLGPPLGNA TYEVLRELLD ISAEEIKRLR SRKII
//
