ID SOCS4_MOUSE Reviewed; 436 AA.
AC Q91ZA6; Q149F7; Q149F8;
DT 16-APR-2002, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 2.
DT 24-JAN-2024, entry version 145.
DE RecName: Full=Suppressor of cytokine signaling 4;
DE Short=SOCS-4;
DE AltName: Full=Suppressor of cytokine signaling 7;
DE Short=SOCS-7;
GN Name=Socs4; Synonyms=Socs7;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Hilton D.J.;
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: SOCS family proteins form part of a classical negative
CC feedback system that regulates cytokine signal transduction. Substrate-
CC recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box
CC protein) E3 ubiquitin-protein ligase complex which mediates the
CC ubiquitination and subsequent proteasomal degradation of target
CC proteins. Inhibits EGF signaling by mediating the degradation of the
CC Tyr-phosphorylated EGF receptor/EGFR (By similarity). {ECO:0000250}.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC -!- DOMAIN: The SOCS box domain mediates the interaction with the Elongin
CC BC complex, an adapter module in different E3 ubiquitin ligase
CC complexes. {ECO:0000250}.
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DR EMBL; AY046322; AAL03942.1; -; mRNA.
DR EMBL; CH466605; EDL20739.1; -; Genomic_DNA.
DR EMBL; BC117814; AAI17815.1; -; mRNA.
DR EMBL; BC117815; AAI17816.1; -; mRNA.
DR CCDS; CCDS26985.1; -.
DR RefSeq; NP_543119.2; NM_080843.2.
DR AlphaFoldDB; Q91ZA6; -.
DR SMR; Q91ZA6; -.
DR BioGRID; 212083; 3.
DR STRING; 10090.ENSMUSP00000066031; -.
DR iPTMnet; Q91ZA6; -.
DR PhosphoSitePlus; Q91ZA6; -.
DR PaxDb; 10090-ENSMUSP00000066031; -.
DR ProteomicsDB; 261546; -.
DR Antibodypedia; 4604; 314 antibodies from 34 providers.
DR DNASU; 67296; -.
DR Ensembl; ENSMUST00000065562.6; ENSMUSP00000066031.5; ENSMUSG00000048379.10.
DR GeneID; 67296; -.
DR KEGG; mmu:67296; -.
DR UCSC; uc007thx.1; mouse.
DR AGR; MGI:1914546; -.
DR CTD; 122809; -.
DR MGI; MGI:1914546; Socs4.
DR VEuPathDB; HostDB:ENSMUSG00000048379; -.
DR eggNOG; KOG4566; Eukaryota.
DR GeneTree; ENSGT00940000161456; -.
DR HOGENOM; CLU_035609_0_0_1; -.
DR InParanoid; Q91ZA6; -.
DR OMA; PSPMKLY; -.
DR OrthoDB; 5362214at2759; -.
DR PhylomeDB; Q91ZA6; -.
DR TreeFam; TF321368; -.
DR UniPathway; UPA00143; -.
DR BioGRID-ORCS; 67296; 4 hits in 77 CRISPR screens.
DR ChiTaRS; Socs4; mouse.
DR PRO; PR:Q91ZA6; -.
DR Proteomes; UP000000589; Chromosome 14.
DR RNAct; Q91ZA6; Protein.
DR Bgee; ENSMUSG00000048379; Expressed in humerus cartilage element and 238 other cell types or tissues.
DR ExpressionAtlas; Q91ZA6; baseline and differential.
DR Genevisible; Q91ZA6; MM.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0005942; C:phosphatidylinositol 3-kinase complex; IBA:GO_Central.
DR GO; GO:0046935; F:1-phosphatidylinositol-3-kinase regulator activity; IBA:GO_Central.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0007175; P:negative regulation of epidermal growth factor-activated receptor activity; ISS:UniProtKB.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IBA:GO_Central.
DR GO; GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; ISS:UniProtKB.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR CDD; cd10385; SH2_SOCS4; 1.
DR CDD; cd03738; SOCS_SOCS4; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR022252; SOCS4/SOCS5_dom.
DR InterPro; IPR035864; SOCS4_SH2.
DR InterPro; IPR037342; SOCS4_SOCS.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF21; SUPPRESSOR OF CYTOKINE SIGNALING 4; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF12610; SOCS; 1.
DR Pfam; PF07525; SOCS_box; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00253; SOCS; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50225; SOCS; 1.
PE 2: Evidence at transcript level;
KW Growth regulation; Reference proteome; SH2 domain;
KW Signal transduction inhibitor; Ubl conjugation pathway.
FT CHAIN 1..436
FT /note="Suppressor of cytokine signaling 4"
FT /id="PRO_0000181248"
FT DOMAIN 283..378
FT /note="SH2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00191"
FT DOMAIN 373..422
FT /note="SOCS box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00194"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10..25
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 12
FT /note="R -> W (in Ref. 1; AAL03942 and 3; AAI17815)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 436 AA; 49918 MW; B64BF54C75F27A21 CRC64;
MAENNSKNVD VRPKTSRSRS ADRKDGYVWS GKKLSWSKKS ESCSESEAIG TVENVEIPLR
SQERQLSCSS IELDLDHSCG HRFLGRSLKQ KLQDAVGQCF PIKNCSGRHS PGLPSKRKIH
ISELMLDKCP FPPRSDLAFR WHFIKRHTVP MSPNSDEWVS ADLSERKLRD AQLKRRNTED
DIPCFSHTNG QPCVITANSA SCTGGHITGS MMNLVTNNSI EDSDMDSEDE IITLCTSSRK
RNKPRWEMEE EILQLEAPPK FHTQIDYVHC LVPDLLQISN NPCYWGVMDK YAAEALLEGK
PEGTFLLRDS AQEDYLFSVS FRRYSRSLHA RIEQWNHNFS FDAHDPCVFH SPDITGLLEH
YKDPSACMFF EPLLSTPLIR TFPFSLQHIC RTVICNCTTY DGIDALPIPS PMKLYLKEYH
YKSKVRLLRI DVPEQQ
//
