ID SORC1_MOUSE Reviewed; 1167 AA.
AC Q9JLC4; Q8VI45; Q922I1; Q9QY21;
DT 13-DEC-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 24-JAN-2024, entry version 141.
DE RecName: Full=VPS10 domain-containing receptor SorCS1;
DE Short=mSorCS;
DE Flags: Precursor;
GN Name=Sorcs1; Synonyms=Sorcs;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=10600506; DOI=10.1006/bbrc.1999.1822;
RA Hermey G., Riedel I.B., Hampe W., Schaller H.C., Hermans-Borgmeyer I.;
RT "Identification and characterization of SorCS, a third member of a novel
RT receptor family.";
RL Biochem. Biophys. Res. Commun. 266:347-351(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=10760602; DOI=10.1016/s0167-4781(00)00044-0;
RA Hermey G., Schaller H.C.;
RT "Alternative splicing of murine SorCS leads to two forms of the receptor
RT that differ completely in their cytoplasmic tails.";
RL Biochim. Biophys. Acta 1491:350-354(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
RC STRAIN=C57BL/6J;
RA Hermey G.;
RT "A third splice variant of mSorCS.";
RL Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 424-1167 (ISOFORM 4).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- INTERACTION:
CC Q9JLC4; Q99523: SORT1; Xeno; NbExp=2; IntAct=EBI-25300487, EBI-1057058;
CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1; Synonyms=SorCSb;
CC IsoId=Q9JLC4-1; Sequence=Displayed;
CC Name=2; Synonyms=SorCSa;
CC IsoId=Q9JLC4-2; Sequence=VSP_006205;
CC Name=3; Synonyms=SorCSc;
CC IsoId=Q9JLC4-3; Sequence=VSP_006206;
CC Name=4;
CC IsoId=Q9JLC4-4; Sequence=VSP_006207;
CC -!- TISSUE SPECIFICITY: Isoform 1 is highly expressed in brain, and at
CC lower levels in heart, liver and kidney. Detected in newborn brain and
CC in adult olfactory bulb and cerebral cortex. Isoform 2 is highly
CC expressed in liver, and at lower levels in heart, brain, kidney and
CC testis.
CC -!- SIMILARITY: Belongs to the VPS10-related sortilin family. SORCS
CC subfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH07486.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AF137367; AAF24748.1; -; mRNA.
DR EMBL; AF195056; AAF68196.1; -; mRNA.
DR EMBL; AF284755; AAL56666.1; -; mRNA.
DR EMBL; BC007486; AAH07486.1; ALT_FRAME; mRNA.
DR AlphaFoldDB; Q9JLC4; -.
DR SMR; Q9JLC4; -.
DR IntAct; Q9JLC4; 1.
DR STRING; 10090.ENSMUSP00000147463; -.
DR GlyConnect; 2823; 5 N-Linked glycans (2 sites).
DR GlyCosmos; Q9JLC4; 9 sites, 5 glycans.
DR GlyGen; Q9JLC4; 10 sites, 5 N-linked glycans (2 sites), 1 O-linked glycan (1 site).
DR iPTMnet; Q9JLC4; -.
DR PhosphoSitePlus; Q9JLC4; -.
DR MaxQB; Q9JLC4; -.
DR PaxDb; 10090-ENSMUSP00000072472; -.
DR ProteomicsDB; 261604; -. [Q9JLC4-1]
DR ProteomicsDB; 261605; -. [Q9JLC4-2]
DR ProteomicsDB; 261606; -. [Q9JLC4-3]
DR ProteomicsDB; 261607; -. [Q9JLC4-4]
DR AGR; MGI:1929666; -.
DR MGI; MGI:1929666; Sorcs1.
DR eggNOG; KOG3511; Eukaryota.
DR InParanoid; Q9JLC4; -.
DR PhylomeDB; Q9JLC4; -.
DR ChiTaRS; Sorcs1; mouse.
DR PRO; PR:Q9JLC4; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q9JLC4; Protein.
DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; ISO:MGI.
DR GO; GO:0006892; P:post-Golgi vesicle-mediated transport; IBA:GO_Central.
DR Gene3D; 2.10.70.80; -; 1.
DR Gene3D; 2.120.10.10; -; 1.
DR Gene3D; 3.30.60.270; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR000601; PKD_dom.
DR InterPro; IPR035986; PKD_dom_sf.
DR InterPro; IPR031777; Sortilin_C.
DR InterPro; IPR031778; Sortilin_N.
DR InterPro; IPR006581; VPS10.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR12106; SORTILIN RELATED; 1.
DR PANTHER; PTHR12106:SF8; VPS10 DOMAIN-CONTAINING RECEPTOR SORCS1; 1.
DR Pfam; PF00801; PKD; 1.
DR Pfam; PF15902; Sortilin-Vps10; 1.
DR Pfam; PF15901; Sortilin_C; 1.
DR SMART; SM00602; VPS10; 1.
DR SUPFAM; SSF110296; Oligoxyloglucan reducing end-specific cellobiohydrolase; 1.
DR SUPFAM; SSF49299; PKD domain; 2.
DR PROSITE; PS50093; PKD; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Glycoprotein; Membrane; Reference proteome; Repeat;
KW Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..33
FT /evidence="ECO:0000255"
FT CHAIN 34..1167
FT /note="VPS10 domain-containing receptor SorCS1"
FT /id="PRO_0000033171"
FT TOPO_DOM 34..1098
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 1099..1119
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1120..1167
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REPEAT 208..219
FT /note="BNR 1"
FT REPEAT 256..267
FT /note="BNR 2"
FT REPEAT 492..503
FT /note="BNR 3"
FT REPEAT 569..580
FT /note="BNR 4"
FT REPEAT 611..622
FT /note="BNR 5"
FT DOMAIN 802..893
FT /note="PKD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00151"
FT REGION 38..68
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 98..151
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1128..1167
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 107..133
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 184
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 352
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 433
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 775
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 815
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 846
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 907
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 928
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1124..1167
FT /note="RVALPSPPSPSAQPGDSSLRLQRPRPATPPSSPKRGSAGAQFAI -> CVFL
FT LLPSYPRPPPPSSFCQVQKQ (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:10600506"
FT /id="VSP_006205"
FT VAR_SEQ 1124..1167
FT /note="RVALPSPPSPSAQPGDSSLRLQRPRPATPPSSPKRGSAGAQFAI -> KIPG
FT INVYAQMQNEKEQELINPVSHSESRPSVPHPDLRRPGQLVDEKVESQLLGK (in
FT isoform 3)"
FT /evidence="ECO:0000303|Ref.3"
FT /id="VSP_006206"
FT VAR_SEQ 1124..1167
FT /note="RVALPSPPSPSAQPGDSSLRLQRPRPATPPSSPKRGSAGAQFAI -> KIPG
FT INVYAQMQNEKEQELINPVSHSESRSSVPHPDLRRPGQLVDEKVESQLLGE (in
FT isoform 4)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_006207"
FT CONFLICT 10
FT /note="S -> Y (in Ref. 1; AAF24748)"
FT /evidence="ECO:0000305"
FT CONFLICT 709
FT /note="Q -> QG (in Ref. 4; AAH07486)"
FT /evidence="ECO:0000305"
FT CONFLICT 766
FT /note="A -> T (in Ref. 4; AAH07486)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1167 AA; 129631 MW; 3563396487105B73 CRC64;
MGKVGAGDGS SAGLSALLAG AGLLMLLAPG VCSSLSCCPP QHPSSTPRRT LTPRGFPHPG
PLGRAPATPP PLFMRPLFAV APGDRALFLE RAGGSRVSVA TAARSGRRRR SGTEPEKIEP
GEGASRSRRD MLKDGGQQGL GTGARDPGKA TRFRMEELRL TSTTFALTGD SAHNQAMVHW
SGHNSSVILI LTKLYDYNLG SITESSLWRS TDYGTTYEKL NDKVGLKTIL SYLYVCPTNK
CKIMLLTDPE IESSLLISSD EGATYQKYRL NFYLQSLLFH PKQEDWILAY SQDQKLYSSA
EFGRRWQLIQ ESVVPNRFYW SVMGSSKEPD LVHLEARTVD GHSIYLTCRM QNCTEANRNK
PFPGYIDPDS LIVQDDYVFV QLTSGGRPHY YVSYRRSPFA QMKLPKYALP KDMHVISTDE
NQVFAAVQEW NQNDTYNLYI SDTRGVYFTL ALENVRSSRG PEGNVMIDLY EVAGIKGMFL
ANKKIDNQVK TFITYNKGRD WRLLQAPDAD LRGDPVHCLL PYCSLHLHLK VSENPYTSGI
IASRDTAPSI IVASGNIGSE LSDSDISMFV SSDAGNTWRQ IFEEEHSILY LDQGGVLVAM
KHTSLPIRHL WLSFDEGRSW SKYSFTSIPL FVDGVLGEPG EETLIMTVFG HFSHRSEWQL
VKVDYKSIFD RRCAEEDYRP WQLHSQGEAC IMGAKRIYKK RKSERKCMQK YAGAMESEPC
VCTEADFDCD YGYERHSNGQ CLPAFWFNPS SLSKDCSLGQ SYLNSAGYRK VVSNNCTDGV
REQYTAKPQK CPGKAPRGLR IVTADGKLTA EQGHNVTLMV QLEEGDVQRT LIQVDFGDGI
AVSYVNLSSM EDGIKHVYQN VGIFRVTVQV DNSLGSDSAV LYLHVTCPLE HVHLSLPFVT
TKNKEVNATA VLWPSQVGTL TYVWWYGNNT EPLITLEGSI SFKFTSEGMN TITVQVSAGN
AILQDTKTIA VYEEFRSLRL AFSPNLDDYN PDIPEWRRDI SRVIKKSLVE ATGIPSQHIL
VAVLPGLPTA AELFVLPYQD GTRENKRSPE DLEQISEVLI HKLNQNLVHF ELKPGVQVLV
HAAHLTAAPL VDLTPTHSGS AMLMLLSVVF VGLAVFVIYK FKRRVALPSP PSPSAQPGDS
SLRLQRPRPA TPPSSPKRGS AGAQFAI
//
