ID SPA13_HUMAN Reviewed; 307 AA.
AC Q6UXR4;
DT 27-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 105.
DE RecName: Full=Putative serpin A13;
DE Flags: Precursor;
GN Name=SERPINA13P; Synonyms=SERPINA13; ORFNames=UNQ6121/PRO20043;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the serpin family. {ECO:0000305}.
CC -!- CAUTION: Could be the product of a pseudogene. {ECO:0000305}.
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DR EMBL; AY358238; AAQ88605.1; -; mRNA.
DR AlphaFoldDB; Q6UXR4; -.
DR SMR; Q6UXR4; -.
DR MEROPS; I04.966; -.
DR GlyCosmos; Q6UXR4; 2 sites, No reported glycans.
DR GlyGen; Q6UXR4; 2 sites.
DR BioMuta; HGNC:30909; -.
DR DMDM; 74749427; -.
DR MassIVE; Q6UXR4; -.
DR AGR; HGNC:30909; -.
DR GeneCards; SERPINA13P; -.
DR HGNC; HGNC:30909; SERPINA13P.
DR neXtProt; NX_Q6UXR4; -.
DR InParanoid; Q6UXR4; -.
DR PhylomeDB; Q6UXR4; -.
DR Pharos; Q6UXR4; Tdark.
DR PRO; PR:Q6UXR4; -.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; Q6UXR4; Protein.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IBA:GO_Central.
DR Gene3D; 2.30.39.10; Alpha-1-antitrypsin, domain 1; 1.
DR Gene3D; 3.30.497.10; Antithrombin, subunit I, domain 2; 2.
DR InterPro; IPR023796; Serpin_dom.
DR InterPro; IPR000215; Serpin_fam.
DR InterPro; IPR036186; Serpin_sf.
DR InterPro; IPR042178; Serpin_sf_1.
DR InterPro; IPR042185; Serpin_sf_2.
DR PANTHER; PTHR11461; SERINE PROTEASE INHIBITOR, SERPIN; 1.
DR PANTHER; PTHR11461:SF129; SERPIN A13-RELATED; 1.
DR Pfam; PF00079; Serpin; 2.
DR SMART; SM00093; SERPIN; 1.
DR SUPFAM; SSF56574; Serpins; 1.
PE 5: Uncertain;
KW Glycoprotein; Protease inhibitor; Reference proteome; Secreted;
KW Serine protease inhibitor; Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..307
FT /note="Putative serpin A13"
FT /id="PRO_0000041979"
FT CARBOHYD 150
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 250
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 307 AA; 34864 MW; 6C29FB569304FC0B CRC64;
MEASRWWLLV TVLMAGAHCV ALVDQEASDL IHSGPQDSSP GPALPCHKIS VSNIDFAFKL
YRQLALNAPG ENILFFPVSI SLALAMLSWG APVASRTQLL EGLGFTLTVV PEEEIQEGFW
DLLIRLRGQG PRLLLTMDQR RFSGLGARAN QSLEEAQKHI DEYTEQQTQG KLGAWEKDLG
SETTAVLVNH MLLRAEWMKP FDSHATSPKE FFVDEHSAVW VPMMKEKASH RFLHDRELQC
SVLRMDHAGN TTTFFIFPNR GKMRHLEDAL LPETLIKWDS LLRTRELDFH FPKFSISRTC
RLEMLLP
//
