ID SPB8_BOVIN Reviewed; 374 AA.
AC Q5BIR5;
DT 05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 12-APR-2005, sequence version 1.
DT 24-JAN-2024, entry version 109.
DE RecName: Full=Serpin B8;
GN Name=SERPINB8;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT "Characterization of 954 bovine full-CDS cDNA sequences.";
RL BMC Genomics 6:166-166(2005).
CC -!- FUNCTION: Has an important role in epithelial desmosome-mediated cell-
CC cell adhesion. {ECO:0000250|UniProtKB:P50452}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the serpin family. Ov-serpin subfamily.
CC {ECO:0000305}.
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DR EMBL; BT021159; AAX31341.1; -; mRNA.
DR RefSeq; NP_001030364.1; NM_001035287.1.
DR RefSeq; XP_015315533.1; XM_015460047.1.
DR AlphaFoldDB; Q5BIR5; -.
DR SMR; Q5BIR5; -.
DR STRING; 9913.ENSBTAP00000001597; -.
DR MEROPS; I04.013; -.
DR PaxDb; 9913-ENSBTAP00000001597; -.
DR PeptideAtlas; Q5BIR5; -.
DR Ensembl; ENSBTAT00000001597.5; ENSBTAP00000001597.4; ENSBTAG00000001207.5.
DR GeneID; 513825; -.
DR KEGG; bta:513825; -.
DR CTD; 5271; -.
DR VEuPathDB; HostDB:ENSBTAG00000001207; -.
DR eggNOG; KOG2392; Eukaryota.
DR GeneTree; ENSGT00940000154835; -.
DR HOGENOM; CLU_023330_0_2_1; -.
DR InParanoid; Q5BIR5; -.
DR OMA; ETCDFLP; -.
DR TreeFam; TF352619; -.
DR Reactome; R-BTA-75205; Dissolution of Fibrin Clot.
DR Proteomes; UP000009136; Chromosome 24.
DR Bgee; ENSBTAG00000001207; Expressed in zone of skin and 104 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IBA:GO_Central.
DR CDD; cd19567; serpinB8_CAP-2; 1.
DR Gene3D; 2.30.39.10; Alpha-1-antitrypsin, domain 1; 1.
DR Gene3D; 3.30.497.10; Antithrombin, subunit I, domain 2; 1.
DR InterPro; IPR023795; Serpin_CS.
DR InterPro; IPR023796; Serpin_dom.
DR InterPro; IPR000215; Serpin_fam.
DR InterPro; IPR036186; Serpin_sf.
DR InterPro; IPR042178; Serpin_sf_1.
DR InterPro; IPR042185; Serpin_sf_2.
DR PANTHER; PTHR11461; SERINE PROTEASE INHIBITOR, SERPIN; 1.
DR PANTHER; PTHR11461:SF166; SERPIN B8; 1.
DR Pfam; PF00079; Serpin; 1.
DR SMART; SM00093; SERPIN; 1.
DR SUPFAM; SSF56574; Serpins; 1.
DR PROSITE; PS00284; SERPIN; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Protease inhibitor; Reference proteome;
KW Serine protease inhibitor.
FT CHAIN 1..374
FT /note="Serpin B8"
FT /id="PRO_0000094110"
FT SITE 339..340
FT /note="Reactive bond"
FT /evidence="ECO:0000250"
SQ SEQUENCE 374 AA; 42173 MW; 156506FF9023092E CRC64;
MDALCEANGT FAINLLKMLG EEDHLRNVFF SPLSLSSVLT MVLMGAKGNT AAQMSQALCL
NESGDVHRGF QSLLREVSTS GPKCLLRTAN RLFGEKTCDF LPAFKESCQK FYQADLEELS
FAEDTEECRK HINDWVMEKT DGKISEILGA GTVSPLTKLV LVNAIYFKGK WNEQFDRKHT
RGMPFKTNQE KKTVQMMFKQ AKFKMGHVEE VPAQVLELPY VGAELSMLIL LPDENTDLAV
VEKALTYEKF RTWTSPEKLT EEKVQVFLPR LKLEASYDLE AFLRSLGMTD AFEEAKADFS
GMSAKKNVPM SKVAHKCFVE VNEEGTEAAG ATAVVRNSRC CRMEPKFCAD HPFLFFIRHR
ETNSILFCGR FSSP
//
