ID STC2_MOUSE Reviewed; 296 AA.
AC O88452;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 24-JAN-2024, entry version 148.
DE RecName: Full=Stanniocalcin-2;
DE Short=STC-2;
DE Flags: Precursor;
GN Name=Stc2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=9723890; DOI=10.1016/s0303-7207(98)00097-5;
RA Chang A.C.-M., Reddel R.R.;
RT "Identification of a second stanniocalcin cDNA in mouse and human:
RT stanniocalcin 2.";
RL Mol. Cell. Endocrinol. 141:95-99(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], AND CHARACTERIZATION.
RC TISSUE=Mammary carcinoma;
RX PubMed=10450831; DOI=10.1055/s-2007-978764;
RA Moore E.E., Kuestner R.E., Conklin D.C., Whitmore T.E., Downey W.,
RA Buddle M.M., Adams R.L., Bell L.A., Thompson D.L., Wolf A., Chen L.,
RA Stamm M.R., Grant F.J., Lok S., Ren H., de Jongh K.S.;
RT "Stanniocalcin 2: characterization of the protein and its localization to
RT human pancreatic alpha cells.";
RL Horm. Metab. Res. 31:406-414(1999).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Has an anti-hypocalcemic action on calcium and phosphate
CC homeostasis.
CC -!- SUBUNIT: Homodimer; disulfide-linked. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Found in a variety of tissues including skeletal
CC muscle, small intestine, kidney, liver and brain.
CC -!- SIMILARITY: Belongs to the stanniocalcin family. {ECO:0000305}.
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DR EMBL; AF056244; AAC27507.1; -; mRNA.
DR EMBL; AF031035; AAD01921.1; -; mRNA.
DR EMBL; BC012206; AAH12206.1; -; mRNA.
DR CCDS; CCDS24512.1; -.
DR RefSeq; NP_035621.1; NM_011491.3.
DR AlphaFoldDB; O88452; -.
DR SMR; O88452; -.
DR STRING; 10090.ENSMUSP00000020546; -.
DR GlyCosmos; O88452; 1 site, No reported glycans.
DR GlyGen; O88452; 1 site.
DR PhosphoSitePlus; O88452; -.
DR PaxDb; 10090-ENSMUSP00000020546; -.
DR PeptideAtlas; O88452; -.
DR ProteomicsDB; 258662; -.
DR Antibodypedia; 28957; 445 antibodies from 34 providers.
DR DNASU; 20856; -.
DR Ensembl; ENSMUST00000020546.3; ENSMUSP00000020546.3; ENSMUSG00000020303.3.
DR GeneID; 20856; -.
DR KEGG; mmu:20856; -.
DR UCSC; uc007iik.1; mouse.
DR AGR; MGI:1316731; -.
DR CTD; 8614; -.
DR MGI; MGI:1316731; Stc2.
DR VEuPathDB; HostDB:ENSMUSG00000020303; -.
DR eggNOG; ENOG502QU7E; Eukaryota.
DR GeneTree; ENSGT00390000005989; -.
DR HOGENOM; CLU_064102_0_0_1; -.
DR InParanoid; O88452; -.
DR OMA; RLGQFMT; -.
DR OrthoDB; 4573585at2759; -.
DR PhylomeDB; O88452; -.
DR TreeFam; TF324693; -.
DR Reactome; R-MMU-381426; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).
DR Reactome; R-MMU-8957275; Post-translational protein phosphorylation.
DR BioGRID-ORCS; 20856; 0 hits in 79 CRISPR screens.
DR PRO; PR:O88452; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; O88452; Protein.
DR Bgee; ENSMUSG00000020303; Expressed in aortic valve and 176 other cell types or tissues.
DR ExpressionAtlas; O88452; baseline and differential.
DR Genevisible; O88452; MM.
DR GO; GO:0005783; C:endoplasmic reticulum; IDA:MGI.
DR GO; GO:0005576; C:extracellular region; ISO:MGI.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005794; C:Golgi apparatus; IDA:MGI.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; ISO:MGI.
DR GO; GO:0019899; F:enzyme binding; ISO:MGI.
DR GO; GO:0020037; F:heme binding; ISO:MGI.
DR GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR GO; GO:0042803; F:protein homodimerization activity; ISO:MGI.
DR GO; GO:0055074; P:calcium ion homeostasis; IGI:MGI.
DR GO; GO:0071456; P:cellular response to hypoxia; IEA:Ensembl.
DR GO; GO:0046697; P:decidualization; IEA:Ensembl.
DR GO; GO:0007566; P:embryo implantation; IEA:Ensembl.
DR GO; GO:0030968; P:endoplasmic reticulum unfolded protein response; IMP:MGI.
DR GO; GO:0006874; P:intracellular calcium ion homeostasis; IMP:MGI.
DR GO; GO:0010629; P:negative regulation of gene expression; ISO:MGI.
DR GO; GO:0040015; P:negative regulation of multicellular organism growth; IMP:MGI.
DR GO; GO:0046885; P:regulation of hormone biosynthetic process; ISO:MGI.
DR GO; GO:2000118; P:regulation of sodium-dependent phosphate transport; ISO:MGI.
DR GO; GO:2001256; P:regulation of store-operated calcium entry; IMP:MGI.
DR GO; GO:0034976; P:response to endoplasmic reticulum stress; IMP:MGI.
DR GO; GO:0006979; P:response to oxidative stress; IMP:MGI.
DR GO; GO:0043434; P:response to peptide hormone; IEA:Ensembl.
DR GO; GO:0033280; P:response to vitamin D; IEA:Ensembl.
DR InterPro; IPR004978; Stanniocalcin.
DR PANTHER; PTHR11245; STANNIOCALCIN; 1.
DR PANTHER; PTHR11245:SF2; STANNIOCALCIN-2; 1.
DR Pfam; PF03298; Stanniocalcin; 1.
PE 1: Evidence at protein level;
KW Disulfide bond; Glycoprotein; Hormone; Reference proteome; Secreted;
KW Signal.
FT SIGNAL 1..24
FT /evidence="ECO:0000255"
FT CHAIN 25..296
FT /note="Stanniocalcin-2"
FT /id="PRO_0000033305"
FT REGION 21..44
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 218..296
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 231..262
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 267..285
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 73
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 296 AA; 32602 MW; 0C1EF4008912DE68 CRC64;
MCAERLGQFV TLALVFATLD PAQGTDSTNP PEGPQDRSSQ QKGRLSLQNT AEIQHCLVNA
GDVGCGVFEC FENNSCEIQG LHGICMTFLH NAGKFDAQGK SFIKDALRCK AHALRHKFGC
ISRKCPAIRE MVFQLQRECY LKHDLCSAAQ ENVGVIVEMI HFKDLLLHEP YVDLVNLLLT
CGEDVKEAVT RSVQAQCEQS WGGLCSILSF CTSNIQRPPT AAPEHQPLAD RAQLSRPHHR
DTDHHLTANR GAKGERGSKS HPNAHARGRT GGQSAQGPSG SSEWEDEQSE YSDIRR
//
