ID STS1_TALSN Reviewed; 315 AA.
AC B8LTU5;
DT 31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT 03-MAR-2009, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=Tethering factor for nuclear proteasome sts1;
GN Name=sts1; ORFNames=TSTA_071710;
OS Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL
OS 1006) (Penicillium stipitatum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Trichocomaceae; Talaromyces;
OC Talaromyces sect. Talaromyces.
OX NCBI_TaxID=441959;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006;
RX PubMed=25676766; DOI=10.1128/genomea.01559-14;
RA Nierman W.C., Fedorova-Abrams N.D., Andrianopoulos A.;
RT "Genome sequence of the AIDS-associated pathogen Penicillium marneffei
RT (ATCC18224) and its near taxonomic relative Talaromyces stipitatus
RT (ATCC10500).";
RL Genome Announc. 3:E0155914-E0155914(2015).
CC -!- FUNCTION: Involved in ubiquitin-mediated protein degradation.
CC Regulatory factor in the ubiquitin/proteasome pathway that controls the
CC turnover of proteasome substrates. Targets proteasomes to the nucleus
CC and facilitates the degradation of nuclear proteins (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Binds the proteasome. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the cut8/STS1 family. {ECO:0000305}.
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DR EMBL; EQ962652; EED23775.1; -; Genomic_DNA.
DR RefSeq; XP_002341162.1; XM_002341121.1.
DR AlphaFoldDB; B8LTU5; -.
DR SMR; B8LTU5; -.
DR STRING; 441959.B8LTU5; -.
DR GeneID; 8100238; -.
DR VEuPathDB; FungiDB:TSTA_071710; -.
DR eggNOG; ENOG502RNK4; Eukaryota.
DR HOGENOM; CLU_033658_0_0_1; -.
DR InParanoid; B8LTU5; -.
DR OMA; DYTPHFL; -.
DR OrthoDB; 2720936at2759; -.
DR PhylomeDB; B8LTU5; -.
DR Proteomes; UP000001745; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0071630; P:nuclear protein quality control by the ubiquitin-proteasome system; IEA:InterPro.
DR GO; GO:0031144; P:proteasome localization; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR Gene3D; 1.20.58.1590; Tethering factor for nuclear proteasome Cut8/Sts1; 1.
DR InterPro; IPR013868; Cut8/Sts1_fam.
DR InterPro; IPR038422; Cut8/Sts1_sf.
DR PANTHER; PTHR28032; FI02826P; 1.
DR PANTHER; PTHR28032:SF1; FI02826P; 1.
DR Pfam; PF08559; Cut8; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Nucleus; Protein transport; Reference proteome; Transport.
FT CHAIN 1..315
FT /note="Tethering factor for nuclear proteasome sts1"
FT /id="PRO_0000409434"
FT REGION 1..83
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 20..34
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 315 AA; 34608 MW; FCFD69610F714835 CRC64;
MNSLVATPPV PPHFYEHSRF SPSRSMSTPA QQSSNRKRKA EDDGNDVDIR MSASPTNSPA
FTPRPLPNRQ MKRSRPNVSG RPLSLPRLLE TLDTDALRSV LQAVCQRHPE LGDEVVHTAP
RPSVSSTLQV LRNYQSTLQT SIPLGSGEYL SDYAYNRVKQ HLFNLLDALS DFTPHFLPPN
ESQTSVSLTY LDGATDIIHS LPKWQTPRHN IGRDSAYEEI CKAWVLVIRE AAKRGGGIQL
QYGGWDQKLA KHNETSGGKL QDAINELQNS LGWMGSSALP GVGAAGTQGG DQTSIREQLL
SGTYGMGMPL KVGPW
//
