ID STX2_CAEEL Reviewed; 299 AA.
AC Q20574;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 4.
DT 27-MAR-2024, entry version 145.
DE RecName: Full=Putative syntaxin-2;
GN Name=syx-2; Synonyms=syn-2; ORFNames=F48F7.2;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Potentially involved in docking of synaptic vesicles at
CC presynaptic active zones. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type IV
CC membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the syntaxin family. {ECO:0000305}.
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DR EMBL; Z69661; CAA93492.4; -; Genomic_DNA.
DR PIR; E89697; E89697.
DR PIR; T22390; T22390.
DR RefSeq; NP_510323.3; NM_077922.4.
DR AlphaFoldDB; Q20574; -.
DR SMR; Q20574; -.
DR STRING; 6239.F48F7.2.2; -.
DR iPTMnet; Q20574; -.
DR EPD; Q20574; -.
DR PaxDb; 6239-F48F7-2-2; -.
DR PeptideAtlas; Q20574; -.
DR EnsemblMetazoa; F48F7.2.1; F48F7.2.1; WBGene00006372.
DR GeneID; 181505; -.
DR KEGG; cel:CELE_F48F7.2; -.
DR UCSC; F48F7.2.1; c. elegans.
DR AGR; WB:WBGene00006372; -.
DR WormBase; F48F7.2; CE37520; WBGene00006372; syx-2.
DR eggNOG; KOG0810; Eukaryota.
DR GeneTree; ENSGT01050000244948; -.
DR HOGENOM; CLU_931369_0_0_1; -.
DR InParanoid; Q20574; -.
DR OMA; AMRKKIC; -.
DR OrthoDB; 2879355at2759; -.
DR PhylomeDB; Q20574; -.
DR Reactome; R-CEL-449836; Other interleukin signaling.
DR PRO; PR:Q20574; -.
DR Proteomes; UP000001940; Chromosome X.
DR Bgee; WBGene00006372; Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues.
DR GO; GO:0012505; C:endomembrane system; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0048787; C:presynaptic active zone membrane; IBA:GO_Central.
DR GO; GO:0031201; C:SNARE complex; IBA:GO_Central.
DR GO; GO:0008021; C:synaptic vesicle; IBA:GO_Central.
DR GO; GO:0005484; F:SNAP receptor activity; IBA:GO_Central.
DR GO; GO:0000149; F:SNARE binding; IBA:GO_Central.
DR GO; GO:0006887; P:exocytosis; IBA:GO_Central.
DR GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR GO; GO:0007614; P:short-term memory; IGI:WormBase.
DR GO; GO:0016081; P:synaptic vesicle docking; ISS:UniProtKB.
DR GO; GO:0031629; P:synaptic vesicle fusion to presynaptic active zone membrane; IBA:GO_Central.
DR GO; GO:0048278; P:vesicle docking; IBA:GO_Central.
DR CDD; cd15848; SNARE_syntaxin1-like; 1.
DR CDD; cd00179; SynN; 1.
DR Gene3D; 1.20.5.110; -; 1.
DR Gene3D; 1.20.58.70; -; 1.
DR InterPro; IPR010989; SNARE.
DR InterPro; IPR045242; Syntaxin.
DR InterPro; IPR006012; Syntaxin/epimorphin_CS.
DR InterPro; IPR006011; Syntaxin_N.
DR InterPro; IPR000727; T_SNARE_dom.
DR PANTHER; PTHR19957; SYNTAXIN; 1.
DR PANTHER; PTHR19957:SF113; SYNTAXIN-2-RELATED; 1.
DR Pfam; PF05739; SNARE; 1.
DR Pfam; PF00804; Syntaxin; 1.
DR SMART; SM00503; SynN; 1.
DR SMART; SM00397; t_SNARE; 1.
DR SUPFAM; SSF47661; t-snare proteins; 1.
DR PROSITE; PS00914; SYNTAXIN; 1.
DR PROSITE; PS50192; T_SNARE; 1.
PE 3: Inferred from homology;
KW Coiled coil; Membrane; Neurotransmitter transport; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..299
FT /note="Putative syntaxin-2"
FT /id="PRO_0000210240"
FT TOPO_DOM 1..270
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 271..291
FT /note="Helical; Anchor for type IV membrane protein"
FT /evidence="ECO:0000255"
FT TOPO_DOM 292..299
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT DOMAIN 193..255
FT /note="t-SNARE coiled-coil homology"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00202"
FT COILED 112..146
FT /evidence="ECO:0000255"
SQ SEQUENCE 299 AA; 34506 MW; 83B18CD4872E783C CRC64;
MRDRLNEFQS RVTDRFDEVE LSPARPPSAA EYVDRRFEEV RNAIASVRGE IEKLRRDQQH
VLALTIADPR DKNILENQIG TIRRRTGDLR KLVRQAEDDF LEFTKQVQSV TEKRMRQNQL
ELLKDNLNKL INLFNETHQD YKSRVSVRVR RQLQTVGQDL TDEDINRIME NSGSEQLFFR
EVNPLSVSGQ AAYEDVKKRH GEIKDLENNI AMLEEIFLDL QHLTEAQDEM VTNIDNNVEN
GLEQVKQGSA NVKTAVEYKK SAMRKKICVA AILITILLIL IIVAIILAVV LSRGNNNNK
//
