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Database: UniProt
Entry: SUB10_ARTOC
LinkDB: SUB10_ARTOC
Original site: SUB10_ARTOC 
ID   SUB10_ARTOC             Reviewed;         401 AA.
AC   C5FX37;
DT   05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 1.
DT   08-MAY-2019, entry version 53.
DE   RecName: Full=Subtilisin-like protease 10;
DE            EC=3.4.21.-;
DE   Flags: Precursor;
GN   Name=SUB10; ORFNames=MCYG_07696;
OS   Arthroderma otae (strain ATCC MYA-4605 / CBS 113480) (Microsporum
OS   canis).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Arthrodermataceae; Microsporum.
OX   NCBI_TaxID=554155;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4605 / CBS 113480;
RX   PubMed=22951933; DOI=10.1128/mBio.00259-12;
RA   Martinez D.A., Oliver B.G., Graeser Y., Goldberg J.M., Li W.,
RA   Martinez-Rossi N.M., Monod M., Shelest E., Barton R.C., Birch E.,
RA   Brakhage A.A., Chen Z., Gurr S.J., Heiman D., Heitman J., Kosti I.,
RA   Rossi A., Saif S., Samalova M., Saunders C.W., Shea T.,
RA   Summerbell R.C., Xu J., Young S., Zeng Q., Birren B.W., Cuomo C.A.,
RA   White T.C.;
RT   "Comparative genome analysis of Trichophyton rubrum and related
RT   dermatophytes reveals candidate genes involved in infection.";
RL   MBio 3:E259-E259(2012).
CC   -!- FUNCTION: Secreted subtilisin-like serine protease with
CC       keratinolytic activity that contributes to pathogenicity.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the peptidase S8 family. {ECO:0000305}.
DR   EMBL; DS995707; EEQ34877.1; -; Genomic_DNA.
DR   RefSeq; XP_002843913.1; XM_002843867.1.
DR   SMR; C5FX37; -.
DR   STRING; 63405.XP_002843913.1; -.
DR   PRIDE; C5FX37; -.
DR   EnsemblFungi; EEQ34877; EEQ34877; MCYG_07696.
DR   GeneID; 9228037; -.
DR   eggNOG; KOG1153; Eukaryota.
DR   eggNOG; COG1404; LUCA.
DR   OrthoDB; 921536at2759; -.
DR   Proteomes; UP000002035; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0009405; P:pathogenesis; IEA:UniProtKB-KW.
DR   CDD; cd04077; Peptidases_S8_PCSK9_Proteinase; 1.
DR   Gene3D; 3.30.70.80; -; 1.
DR   Gene3D; 3.40.50.200; -; 1.
DR   InterPro; IPR034193; PCSK9_ProteinaseK-like.
DR   InterPro; IPR000209; Peptidase_S8/S53_dom.
DR   InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR   InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR   InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR   InterPro; IPR010259; S8pro/Inhibitor_I9.
DR   InterPro; IPR037045; S8pro/Inhibitor_I9_sf.
DR   Pfam; PF05922; Inhibitor_I9; 1.
DR   Pfam; PF00082; Peptidase_S8; 1.
DR   PRINTS; PR00723; SUBTILISIN.
DR   SUPFAM; SSF52743; SSF52743; 1.
DR   PROSITE; PS00138; SUBTILASE_SER; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Glycoprotein; Hydrolase; Protease;
KW   Reference proteome; Secreted; Serine protease; Signal; Virulence;
KW   Zymogen.
FT   SIGNAL        1     19       {ECO:0000255}.
FT   PROPEP       20    116       {ECO:0000250}.
FT                                /FTId=PRO_0000406394.
FT   CHAIN       117    401       Subtilisin-like protease 10.
FT                                /FTId=PRO_0000406395.
FT   DOMAIN       35    112       Inhibitor I9. {ECO:0000255}.
FT   DOMAIN      139    364       Peptidase S8.
FT   ACT_SITE    158    158       Charge relay system.
FT                                {ECO:0000255|PROSITE-ProRule:PRU10082}.
FT   ACT_SITE    189    189       Charge relay system.
FT                                {ECO:0000255|PROSITE-ProRule:PRU10082}.
FT   ACT_SITE    347    347       Charge relay system.
FT                                {ECO:0000255|PROSITE-ProRule:PRU10082}.
FT   CARBOHYD    250    250       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    397    397       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
SQ   SEQUENCE   401 AA;  42034 MW;  EAF5E564DE9776EC CRC64;
     MLFLKAVIAI LSVLPAADAA AILNFENKQG IIPDSYIVVL KNDISSDDFK SHVAWATGVH
     NANVAKRDVP LAGMQRTFEM DIFKGYSGAF DRATLDDLLK NEQVDYIEPD RMASAQGWTT
     QGNAPSWGLG RISHQQRGNT DYVFDSTAGR GITIYGVDSG IDILHAEFGG RATWGANFFN
     NINTDEFGHG THTAATFGGT NYGVAKNVNI VAVKVLGDQG QGPWSSIIDG LQWAVNDARE
     KGILGKAIIN FSVGGPSSRA ADNALTAAHN AGVFVSAAAG NDGADALNYT PGTARSICVI
     GNINENDYRF TGNGASNWGT RIDLWAPGTD ILSALPQGRY GPMTGTSMAA PHVAGSVAIL
     MASGGVSTAE ACGVLKDMST PSVIEPGQGS TNRLLYNGSG Q
//
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