ID SWET1_DANRE Reviewed; 219 AA.
AC Q5EB14;
DT 22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 22-JUL-2008, sequence version 2.
DT 27-MAR-2024, entry version 105.
DE RecName: Full=Sugar transporter SWEET1;
DE AltName: Full=RAG1-activating protein 1;
DE AltName: Full=Solute carrier family 50 member 1;
GN Name=slc50a1; Synonyms=rag1ap1; ORFNames=zgc:113092;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Mediates sugar transport across membranes. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Multi-
CC pass membrane protein {ECO:0000250}. Cell membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SWEET sugar transporter family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH90168.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; BC090168; AAH90168.1; ALT_INIT; mRNA.
DR RefSeq; NP_001012515.1; NM_001012497.1.
DR AlphaFoldDB; Q5EB14; -.
DR SMR; Q5EB14; -.
DR STRING; 7955.ENSDARP00000025588; -.
DR PaxDb; 7955-ENSDARP00000025588; -.
DR GeneID; 503533; -.
DR KEGG; dre:503533; -.
DR AGR; ZFIN:ZDB-GENE-050220-11; -.
DR CTD; 55974; -.
DR ZFIN; ZDB-GENE-050220-11; slc50a1.
DR eggNOG; KOG1623; Eukaryota.
DR HOGENOM; CLU_048643_3_0_1; -.
DR InParanoid; Q5EB14; -.
DR OMA; QLNDYYI; -.
DR OrthoDB; 66728at2759; -.
DR PhylomeDB; Q5EB14; -.
DR TreeFam; TF313635; -.
DR Reactome; R-DRE-189200; Cellular hexose transport.
DR PRO; PR:Q5EB14; -.
DR Proteomes; UP000000437; Chromosome 16.
DR Bgee; ENSDARG00000015158; Expressed in mature ovarian follicle and 19 other cell types or tissues.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0051119; F:sugar transmembrane transporter activity; ISS:UniProtKB.
DR GO; GO:0008643; P:carbohydrate transport; IBA:GO_Central.
DR Gene3D; 1.20.1280.290; -; 2.
DR InterPro; IPR047664; SWEET.
DR InterPro; IPR004316; SWEET_rpt.
DR PANTHER; PTHR10791; RAG1-ACTIVATING PROTEIN 1; 1.
DR PANTHER; PTHR10791:SF30; SUGAR TRANSPORTER SWEET1; 1.
DR Pfam; PF03083; MtN3_slv; 2.
PE 2: Evidence at transcript level;
KW Cell membrane; Golgi apparatus; Membrane; Reference proteome; Repeat;
KW Sugar transport; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..219
FT /note="Sugar transporter SWEET1"
FT /id="PRO_0000345119"
FT TRANSMEM 3..23
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 38..58
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 63..83
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 98..118
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 125..145
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 156..176
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TRANSMEM 189..209
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT DOMAIN 5..90
FT /note="MtN3/slv 1"
FT DOMAIN 124..204
FT /note="MtN3/slv 2"
SQ SEQUENCE 219 AA; 24803 MW; FBFE2686A5A8095F CRC64;
MDFLQLLSCA CIIFTVGMFT TGLTDLKKMK ATQSADNVQF LPFLTTCLNN LGWLYYGLLK
GDGTVIFVNI IGAFLQTVYI ATYCHYTKEK RRVYTQTLLM VSVLCVAWVY FSLVISPGEA
QLSQLGLTCS VFTISMYLSP LADLLDIMRT KSVERLSFSL TVATFFTSTS WTLYGLQLGD
YYIMVPNTPG IFTSLIRFFL FWWFGAVIPQ IPSYKLIQI
//
