ID SYM1_SCHPO Reviewed; 206 AA.
AC O14142;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 27-MAR-2024, entry version 116.
DE RecName: Full=Protein sym1;
GN Name=sym1; ORFNames=SPAC3G6.05;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000269|PubMed:16823372}; Multi-pass membrane protein
CC {ECO:0000269|PubMed:16823372}.
CC -!- SIMILARITY: Belongs to the peroxisomal membrane protein PXMP2/4 family.
CC {ECO:0000305}.
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DR EMBL; CU329670; CAB16281.1; -; Genomic_DNA.
DR PIR; T38724; T38724.
DR RefSeq; NP_594971.1; NM_001020402.2.
DR AlphaFoldDB; O14142; -.
DR BioGRID; 279623; 2.
DR STRING; 284812.O14142; -.
DR MaxQB; O14142; -.
DR PaxDb; 4896-SPAC3G6-05-1; -.
DR EnsemblFungi; SPAC3G6.05.1; SPAC3G6.05.1:pep; SPAC3G6.05.
DR GeneID; 2543194; -.
DR KEGG; spo:SPAC3G6.05; -.
DR PomBase; SPAC3G6.05; -.
DR VEuPathDB; FungiDB:SPAC3G6.05; -.
DR eggNOG; KOG1944; Eukaryota.
DR HOGENOM; CLU_049109_8_0_1; -.
DR InParanoid; O14142; -.
DR OMA; CCFWPPT; -.
DR PhylomeDB; O14142; -.
DR Reactome; R-SPO-9033241; Peroxisomal protein import.
DR PRO; PR:O14142; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005739; C:mitochondrion; HDA:PomBase.
DR GO; GO:0015267; F:channel activity; TAS:PomBase.
DR GO; GO:0000002; P:mitochondrial genome maintenance; TAS:PomBase.
DR GO; GO:1990542; P:mitochondrial transmembrane transport; TAS:PomBase.
DR InterPro; IPR007248; Mpv17_PMP22.
DR PANTHER; PTHR11266; PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17; 1.
DR PANTHER; PTHR11266:SF119; PROTEIN SYM1; 1.
DR Pfam; PF04117; Mpv17_PMP22; 1.
PE 3: Inferred from homology;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..206
FT /note="Protein sym1"
FT /id="PRO_0000317316"
FT TRANSMEM 107..127
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 169..189
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 206 AA; 23410 MW; B4450AEE0B02B09E CRC64;
MFSRFATRYN ALFEKAPIMT MCLTAGTLGG ISDAVAQGLT IYQTNKNAMI GLDGVRLNTH
PEIPSIKRVL QFVTFGFAIS PFQFRWLRLL SAKFPIEKGA INVVKRVLLD QAVFAPFGTA
FFFSWMTLAE GKGFRGAYDK LQAVFWPTLK ANYMVWPFFQ TVNFWLMPLQ YQMPFACTVA
IFWNIFLSLK NASSMQESGS QEIELF
//
