ID T0HGX6_9SPHN Unreviewed; 357 AA.
AC T0HGX6;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE SubName: Full=Zinc-binding dehydrogenase {ECO:0000313|EMBL:EQA96788.1};
GN ORFNames=L485_22150 {ECO:0000313|EMBL:EQA96788.1};
OS Sphingobium baderi LL03.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Sphingomonadales;
OC Sphingomonadaceae; Sphingobium.
OX NCBI_TaxID=1114964 {ECO:0000313|EMBL:EQA96788.1, ECO:0000313|Proteomes:UP000015524};
RN [1] {ECO:0000313|EMBL:EQA96788.1, ECO:0000313|Proteomes:UP000015524}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LL03 {ECO:0000313|EMBL:EQA96788.1,
RC ECO:0000313|Proteomes:UP000015524};
RX PubMed=24051322;
RA Kaur J., Verma H., Tripathi C., Khurana J.P., Lal R.;
RT "Draft Genome Sequence of a Hexachlorocyclohexane-Degrading Bacterium,
RT Sphingobium baderi Strain LL03T.";
RL Genome Announc. 1:e00751-13(2013).
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947,
CC ECO:0000256|RuleBase:RU361277};
CC -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC family. {ECO:0000256|ARBA:ARBA00008072, ECO:0000256|RuleBase:RU361277}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EQA96788.1}.
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DR EMBL; ATIB01000088; EQA96788.1; -; Genomic_DNA.
DR RefSeq; WP_021246955.1; NZ_KQ130471.1.
DR AlphaFoldDB; T0HGX6; -.
DR PATRIC; fig|1114964.3.peg.4343; -.
DR eggNOG; COG1064; Bacteria.
DR OrthoDB; 9806940at2; -.
DR Proteomes; UP000015524; Unassembled WGS sequence.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd05283; CAD1; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR013149; ADH-like_C.
DR InterPro; IPR013154; ADH-like_N.
DR InterPro; IPR002328; ADH_Zn_CS.
DR InterPro; IPR047109; CAD-like.
DR InterPro; IPR029752; D-isomer_DH_CS1.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020843; PKS_ER.
DR PANTHER; PTHR42683; ALDEHYDE REDUCTASE; 1.
DR PANTHER; PTHR42683:SF85; CINNAMYL ALCOHOL DEHYDROGENASE 6-RELATED; 1.
DR Pfam; PF08240; ADH_N; 1.
DR Pfam; PF00107; ADH_zinc_N; 1.
DR SMART; SM00829; PKS_ER; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00059; ADH_ZINC; 1.
DR PROSITE; PS00065; D_2_HYDROXYACID_DH_1; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|RuleBase:RU361277};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000015524};
KW Zinc {ECO:0000256|RuleBase:RU361277}.
FT DOMAIN 7..343
FT /note="Enoyl reductase (ER)"
FT /evidence="ECO:0000259|SMART:SM00829"
SQ SEQUENCE 357 AA; 38108 MW; 6527138E077E722E CRC64;
MTTKAYGAFA GDRPLEPMDI ERRAPGPHDV QIEIAYCGVC HSDLHQVRSE WAGTLYPCVP
GHEIVGHVAA VGDQVTAFTV GETVGVGCMV DSCQHCHACD ADLEQYCKEG FVGTYNGPTA
DAPGHTLGGY SQRIVVNDRF VLKIRHPEEQ LAAVAPLLCA GITTYSPLRH WQAGPGKKVG
IVGIGGLGHV GVKLAHAMGA HVVAFTTSDS KRDDARALGA DEVVNSRNAD EMAAHANSFD
FILNTVAASH NLDAYTALLK LDGTMTLVGV PEHPHPSPNV GVLIFGRRSI AGSLIGGIAE
TQEMLDFCAE HGITADIEMI PIQQIDQAYD RMQRSDVKYR FVIDSASLAN GTTADER
//
