ID T0HMS5_9SPHN Unreviewed; 400 AA.
AC T0HMS5;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=Acetyl-CoA acetyltransferase {ECO:0008006|Google:ProtNLM};
GN ORFNames=L284_12975 {ECO:0000313|EMBL:EQB14302.1};
OS Novosphingobium lindaniclasticum LE124.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Sphingomonadales;
OC Sphingomonadaceae; Novosphingobium.
OX NCBI_TaxID=1096930 {ECO:0000313|EMBL:EQB14302.1, ECO:0000313|Proteomes:UP000015527};
RN [1] {ECO:0000313|EMBL:EQB14302.1, ECO:0000313|Proteomes:UP000015527}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LE124 {ECO:0000313|EMBL:EQB14302.1,
RC ECO:0000313|Proteomes:UP000015527};
RX PubMed=24029761;
RA Saxena A., Nayyar N., Sangwan N., Kumari R., Khurana J.P., Lal R.;
RT "Genome Sequence of Novosphingobium lindaniclasticum LE124T, Isolated from
RT a Hexachlorocyclohexane Dumpsite.";
RL Genome Announc. 1:e00715-13(2013).
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Thiolase family.
CC {ECO:0000256|ARBA:ARBA00010982, ECO:0000256|RuleBase:RU003557}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EQB14302.1}.
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DR EMBL; ATHL01000082; EQB14302.1; -; Genomic_DNA.
DR RefSeq; WP_021234427.1; NZ_ATHL01000082.1.
DR AlphaFoldDB; T0HMS5; -.
DR PATRIC; fig|1096930.3.peg.2587; -.
DR eggNOG; COG0183; Bacteria.
DR OrthoDB; 7181944at2; -.
DR Proteomes; UP000015527; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:InterPro.
DR CDD; cd00751; thiolase; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR InterPro; IPR002155; Thiolase.
DR InterPro; IPR016039; Thiolase-like.
DR InterPro; IPR020615; Thiolase_acyl_enz_int_AS.
DR InterPro; IPR020610; Thiolase_AS.
DR InterPro; IPR020617; Thiolase_C.
DR InterPro; IPR020613; Thiolase_CS.
DR InterPro; IPR020616; Thiolase_N.
DR NCBIfam; TIGR01930; AcCoA-C-Actrans; 1.
DR PANTHER; PTHR43853; 3-KETOACYL-COA THIOLASE, PEROXISOMAL; 1.
DR PANTHER; PTHR43853:SF2; 3-OXOADIPYL-COA_3-OXO-5,6-DEHYDROSUBERYL-COA THIOLASE; 1.
DR Pfam; PF02803; Thiolase_C; 1.
DR Pfam; PF00108; Thiolase_N; 1.
DR PIRSF; PIRSF000429; Ac-CoA_Ac_transf; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS00098; THIOLASE_1; 1.
DR PROSITE; PS00737; THIOLASE_2; 1.
DR PROSITE; PS00099; THIOLASE_3; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|RuleBase:RU003557};
KW Reference proteome {ECO:0000313|Proteomes:UP000015527};
KW Transferase {ECO:0000256|RuleBase:RU003557}.
FT DOMAIN 10..262
FT /note="Thiolase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00108"
FT DOMAIN 274..397
FT /note="Thiolase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02803"
FT ACT_SITE 89
FT /note="Acyl-thioester intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 354
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 384
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
SQ SEQUENCE 400 AA; 41100 MW; C50688613EE480C7 CRC64;
MSGAFLYPGL RTPVGRYAGT LSQVRPDDLL AGVLRALVDA HSFDVADVED VIMGCTSQAG
EDARNVARHA ALVAGIPVTV AAQTVNRLCG SGLAAVADAA RAIEVGQGGL FIAGGVESMS
RAPFVIAKAE TAFARKATVY EALGERFPNP IIHRQFGRES MPQTGENVAT EQGITREQAD
RFALASQSKY ARAAVDGFFA GEIAPVTITG RKGAISVVDQ DEHPRGSSTL EGLSKLPALF
DGGVVTAGNA SGVNDGAAAM FVGSLAAGEK AGIAPLARIV SAAVAGVEPR VMGYGPVPAS
LKALERANLS LADIDLIELN EAFASQALGC LKLLGVDFED SRVNPNGGAI AIGHPLGMSG
ARLAITAARQ LQRGQGRFAL VTMCIGLGQG IAMVLERQPS
//
