ID T0HRD3_9SPHN Unreviewed; 754 AA.
AC T0HRD3;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 24-JAN-2024, entry version 46.
DE RecName: Full=Ribonuclease R {ECO:0000256|HAMAP-Rule:MF_01895};
DE Short=RNase R {ECO:0000256|HAMAP-Rule:MF_01895};
DE EC=3.1.13.1 {ECO:0000256|HAMAP-Rule:MF_01895};
GN Name=rnr {ECO:0000256|HAMAP-Rule:MF_01895};
GN ORFNames=L284_03335 {ECO:0000313|EMBL:EQB18906.1};
OS Novosphingobium lindaniclasticum LE124.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Sphingomonadales;
OC Sphingomonadaceae; Novosphingobium.
OX NCBI_TaxID=1096930 {ECO:0000313|EMBL:EQB18906.1, ECO:0000313|Proteomes:UP000015527};
RN [1] {ECO:0000313|EMBL:EQB18906.1, ECO:0000313|Proteomes:UP000015527}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LE124 {ECO:0000313|EMBL:EQB18906.1,
RC ECO:0000313|Proteomes:UP000015527};
RX PubMed=24029761;
RA Saxena A., Nayyar N., Sangwan N., Kumari R., Khurana J.P., Lal R.;
RT "Genome Sequence of Novosphingobium lindaniclasticum LE124T, Isolated from
RT a Hexachlorocyclohexane Dumpsite.";
RL Genome Announc. 1:e00715-13(2013).
CC -!- FUNCTION: 3'-5' exoribonuclease that releases 5'-nucleoside
CC monophosphates and is involved in maturation of structured RNAs.
CC {ECO:0000256|HAMAP-Rule:MF_01895}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Exonucleolytic cleavage in the 3'- to 5'-direction to yield
CC nucleoside 5'-phosphates.; EC=3.1.13.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001849, ECO:0000256|HAMAP-
CC Rule:MF_01895};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01895}.
CC -!- SIMILARITY: Belongs to the RNR ribonuclease family. RNase R subfamily.
CC {ECO:0000256|HAMAP-Rule:MF_01895}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EQB18906.1}.
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DR EMBL; ATHL01000028; EQB18906.1; -; Genomic_DNA.
DR AlphaFoldDB; T0HRD3; -.
DR PATRIC; fig|1096930.3.peg.660; -.
DR eggNOG; COG0557; Bacteria.
DR Proteomes; UP000015527; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008859; F:exoribonuclease II activity; IEA:UniProtKB-UniRule.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016070; P:RNA metabolic process; IEA:UniProtKB-UniRule.
DR CDD; cd04471; S1_RNase_R; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR HAMAP; MF_01895; RNase_R; 1.
DR InterPro; IPR040476; CSD2.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR001900; RNase_II/R.
DR InterPro; IPR022966; RNase_II/R_CS.
DR InterPro; IPR004476; RNase_II/RNase_R.
DR InterPro; IPR011805; RNase_R.
DR InterPro; IPR003029; S1_domain.
DR NCBIfam; TIGR00358; 3_prime_RNase; 1.
DR NCBIfam; TIGR02063; RNase_R; 1.
DR PANTHER; PTHR23355:SF9; DIS3-LIKE EXONUCLEASE 2; 1.
DR PANTHER; PTHR23355; RIBONUCLEASE; 1.
DR Pfam; PF17876; CSD2; 1.
DR Pfam; PF00773; RNB; 1.
DR Pfam; PF00575; S1; 1.
DR SMART; SM00955; RNB; 1.
DR SMART; SM00316; S1; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 2.
DR PROSITE; PS01175; RIBONUCLEASE_II; 1.
DR PROSITE; PS50126; S1; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01895};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839, ECO:0000256|HAMAP-
KW Rule:MF_01895};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|HAMAP-Rule:MF_01895};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722, ECO:0000256|HAMAP-Rule:MF_01895};
KW Reference proteome {ECO:0000313|Proteomes:UP000015527};
KW RNA-binding {ECO:0000256|HAMAP-Rule:MF_01895}.
FT DOMAIN 633..714
FT /note="S1 motif"
FT /evidence="ECO:0000259|PROSITE:PS50126"
FT REGION 716..754
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 754 AA; 83768 MW; 4818933BA694F51B CRC64;
MAETMPSKNR PAHGLPSRKQ ILDLIQNSAE PIGKREIARE FGLKGHEKIE LKALLKDMAE
EGLIDGKRTA FHRMGGLPKV TVLRVVEVDE GEPVAIPDTW TPDDATPPPR IRLIEKGRSA
LRKGDRVLAR TEETVTGWRA YPMKKLMLRS EQMLGVVEID GAGKPWLAPV DKRIRNSSPI
SDLGGAEKGE LVLAEPIGRS ARPSVKVTEV LGEPLAPKAF SLIAIHKHGI PNHFDDETIS
EAERAAKMPL SHDKREDLRH LPIVAIDPSD ARDHDDAIWA KPNEEGGFDA LVAIADVSFY
VRPGGHIDRE ARRRGNSVYF PDRVVPMLPE VLSADVCSLR SGEDRAAMAC HLKIDGQGKV
TEWRFTRALV RIDEVIAYEE AQARIDEGRA QQHLQDLWAC WKLLAKARAD RDPLELELPE
RRVKLDEQGR ITEIAIRERL DAHRVVEDFM ISANVAAAKA LEAKVAPVVY RVHETPSREK
LTSLKDYLAT FGRKLSLGQV ITPGLFNRML KDIADESEKA LIMEAVLRSQ TQAYYGPRNE
GHFGLALGSY AHFTSPIRRY ADLLVHRALV DAYGLEQPKP ESDIPAASGL SDRDRDDLGR
VSEAISNYER RAMEAERETI DRYVAAWLSG RVGQVFDTRI TGVQKFGFFA TIIGLGGDGL
VPVSTLGDER FAYDEKAQVL EGESTGTTFG MGQILRLRLA EANPLTGALK FELEEGGGRI
EQRGKPAPLK KKGKHFVSPR GRPGNIRHQG RKKK
//
