ID T0J7G3_9SPHN Unreviewed; 514 AA.
AC T0J7G3;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE SubName: Full=Tryptophan halogenase {ECO:0000313|EMBL:EQB32772.1};
GN ORFNames=M529_08005 {ECO:0000313|EMBL:EQB32772.1};
OS Sphingobium ummariense RL-3.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Sphingomonadales;
OC Sphingomonadaceae; Sphingobium.
OX NCBI_TaxID=1346791 {ECO:0000313|EMBL:EQB32772.1, ECO:0000313|Proteomes:UP000015523};
RN [1] {ECO:0000313|EMBL:EQB32772.1, ECO:0000313|Proteomes:UP000015523}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RL-3 {ECO:0000313|EMBL:EQB32772.1,
RC ECO:0000313|Proteomes:UP000015523};
RX PubMed=24233594;
RA Kohli P., Dua A., Sangwan N., Oldach P., Khurana J.P., Lal R.;
RT "Draft Genome Sequence of Sphingobium ummariense Strain RL-3, a
RT Hexachlorocyclohexane-Degrading Bacterium.";
RL Genome Announc. 1:e00956-13(2013).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EQB32772.1}.
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DR EMBL; AUWY01000058; EQB32772.1; -; Genomic_DNA.
DR RefSeq; WP_021317493.1; NZ_AUWY01000058.1.
DR AlphaFoldDB; T0J7G3; -.
DR STRING; 1346791.M529_08005; -.
DR PATRIC; fig|1346791.3.peg.1539; -.
DR eggNOG; COG0665; Bacteria.
DR OrthoDB; 7178350at2; -.
DR Proteomes; UP000015523; Unassembled WGS sequence.
DR GO; GO:0004497; F:monooxygenase activity; IEA:InterPro.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR006905; Flavin_halogenase.
DR InterPro; IPR033856; Trp_halogen.
DR PANTHER; PTHR43747; FAD-BINDING PROTEIN; 1.
DR PANTHER; PTHR43747:SF4; FLAVIN-DEPENDENT TRYPTOPHAN HALOGENASE; 1.
DR Pfam; PF04820; Trp_halogenase; 1.
DR PIRSF; PIRSF011396; Trp_halogenase; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE 4: Predicted;
KW FAD {ECO:0000256|PIRSR:PIRSR011396-2};
KW Flavoprotein {ECO:0000256|PIRSR:PIRSR011396-2};
KW Nucleotide-binding {ECO:0000256|PIRSR:PIRSR011396-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000015523}.
FT ACT_SITE 81
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-1"
FT BINDING 17..20
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 81
FT /ligand="7-chloro-L-tryptophan"
FT /ligand_id="ChEBI:CHEBI:58713"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 185
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 336
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 345
FT /ligand="L-tryptophan"
FT /ligand_id="ChEBI:CHEBI:57912"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 349
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
SQ SEQUENCE 514 AA; 56427 MW; 078DF9AB9825D22E CRC64;
MATDNPPSLG RIVILGGGTA GWLAAATFSR AWKMPRVTLV ESSDIGIIGV GEGTFPTIRT
TLAGLGVAEA EFLSRADATF KQGVLFDGWA TDADSYFHPF NMPVGGEGEP LLPHWIAAGE
QRASWADSVT VQERVIRAGR APKRPQDPDF SGPMNYAYHF DAARFADYLR TISVAAGVER
IEGTVAEVER APDGDIAALL LAGGKRVEGD IFLDCSGFGA LLIGQTLGSS FTGCGDTLFN
DRALAMQVPY DRPDAPIRPY TLATAHEAGW TWDIGLSERR GIGYVYSSRH CSDEDAEATL
RRYVGPAGDA LAARQLRFQT GYRERQWIGN CIAVGLSAGF FEPLESTGIM LIETALRMIG
DLLVPGTRAT REAAARRFND LMRARFERIV RFLKLHYCIT RRTDTAYWRD NADPASIPED
LRDLLAQWRH RPPSRFDFTV DLETFLPPSY HYILYGMGFR TEPARPMPGA AEARAAFAQV
AAASRAAVAN LPDHRTLLHH YRRQSAPTLA QGIR
//
