ID T0JV44_COLGC Unreviewed; 1399 AA.
AC T0JV44;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=5'-3' exoribonuclease 1 {ECO:0000256|PIRNR:PIRNR006743};
DE EC=3.1.13.- {ECO:0000256|PIRNR:PIRNR006743};
GN ORFNames=CGLO_14029 {ECO:0000313|EMBL:EQB46887.1};
OS Colletotrichum gloeosporioides (strain Cg-14) (Anthracnose fungus)
OS (Glomerella cingulata).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Glomerellales; Glomerellaceae; Colletotrichum;
OC Colletotrichum gloeosporioides species complex.
OX NCBI_TaxID=1237896 {ECO:0000313|EMBL:EQB46887.1, ECO:0000313|Proteomes:UP000015530};
RN [1] {ECO:0000313|Proteomes:UP000015530}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Cg-14 {ECO:0000313|Proteomes:UP000015530};
RX PubMed=23902260; DOI=10.1094/MPMI-03-13-0080-R;
RA Alkan N., Meng X., Friedlander G., Reuveni E., Sukno S., Sherman A.,
RA Thon M., Fluhr R., Prusky D.;
RT "Global aspects of pacC regulation of pathogenicity genes in Colletotrichum
RT gloeosporioides as revealed by transcriptome analysis.";
RL Mol. Plant Microbe Interact. 26:1345-1358(2013).
CC -!- FUNCTION: Multifunctional protein that exhibits several independent
CC functions at different levels of the cellular processes. 5'-3'
CC exonuclease component of the nonsense-mediated mRNA decay (NMD) which
CC is a highly conserved mRNA degradation pathway, an RNA surveillance
CC system whose role is to identify and rid cells of mRNA with premature
CC termination codons and thus prevents accumulation of potentially
CC harmful truncated proteins. {ECO:0000256|PIRNR:PIRNR006743}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|PIRNR:PIRNR006743}.
CC -!- SIMILARITY: Belongs to the 5'-3' exonuclease family.
CC {ECO:0000256|PIRNR:PIRNR006743}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EQB46887.1}.
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DR EMBL; AMYD01003211; EQB46887.1; -; Genomic_DNA.
DR STRING; 1237896.T0JV44; -.
DR eggNOG; KOG2045; Eukaryota.
DR HOGENOM; CLU_001581_1_2_1; -.
DR OMA; VASWPWF; -.
DR OrthoDB; 167745at2759; -.
DR Proteomes; UP000015530; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0004534; F:5'-3' RNA exonuclease activity; IEA:UniProt.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IEA:UniProtKB-KW.
DR CDD; cd18673; PIN_XRN1-2-like; 1.
DR Gene3D; 1.25.40.1050; -; 1.
DR Gene3D; 2.170.260.40; -; 1.
DR Gene3D; 2.30.30.30; -; 1.
DR Gene3D; 2.30.30.750; -; 1.
DR Gene3D; 3.40.50.12390; -; 2.
DR InterPro; IPR027073; 5_3_exoribonuclease.
DR InterPro; IPR016494; 5_3_exoribonuclease_1.
DR InterPro; IPR014722; Rib_uL2_dom2.
DR InterPro; IPR041385; SH3_12.
DR InterPro; IPR040992; XRN1_D1.
DR InterPro; IPR047007; XRN1_D1_sf.
DR InterPro; IPR041106; XRN1_D2_D3.
DR InterPro; IPR041412; Xrn1_helical.
DR InterPro; IPR004859; Xrn1_N.
DR InterPro; IPR047008; XRN1_SH3_sf.
DR PANTHER; PTHR12341:SF83; 5'-3' EXORIBONUCLEASE 1; 1.
DR PANTHER; PTHR12341; 5'->3' EXORIBONUCLEASE; 1.
DR Pfam; PF18129; SH3_12; 1.
DR Pfam; PF18332; XRN1_D1; 1.
DR Pfam; PF18334; XRN1_D2_D3; 1.
DR Pfam; PF17846; XRN_M; 1.
DR Pfam; PF03159; XRN_N; 1.
DR PIRSF; PIRSF006743; Exonuclease_Xnr1; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|PIRNR:PIRNR006743};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839, ECO:0000256|PIRNR:PIRNR006743};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PIRNR:PIRNR006743};
KW Nonsense-mediated mRNA decay {ECO:0000256|PIRNR:PIRNR006743};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722, ECO:0000256|PIRNR:PIRNR006743};
KW Reference proteome {ECO:0000313|Proteomes:UP000015530};
KW RNA-binding {ECO:0000256|PIRNR:PIRNR006743}.
FT DOMAIN 1..228
FT /note="Xrn1 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF03159"
FT DOMAIN 276..670
FT /note="Xrn1 helical"
FT /evidence="ECO:0000259|Pfam:PF17846"
FT DOMAIN 721..909
FT /note="5'-3' exoribonuclease 1 D1"
FT /evidence="ECO:0000259|Pfam:PF18332"
FT DOMAIN 913..1138
FT /note="Exoribonuclease Xrn1 D2/D3"
FT /evidence="ECO:0000259|Pfam:PF18334"
FT DOMAIN 1156..1226
FT /note="5'-3' exoribonuclease 1 SH3-like"
FT /evidence="ECO:0000259|Pfam:PF18129"
FT REGION 1271..1399
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1399 AA; 157248 MW; C7C7FD497369D428 CRC64;
MGVPKFFRWL SERYPAISQL IAENRIPEFD CLYLDMNGII HNCTHKDTGE DTTFRLSEEE
MFIRIFNYIE HLFGKIKPKQ LFFMAIDGVA PRAKMNQQRA RRFRTALDAE KARDKAISEG
VEMPKEPPFD SNCITPGTEF MAKLTQQLKY FVNKKVSEDA DWQGCEIVLS GHEVPGEGEH
KIMEYIRNAK AQPEYDPNVR HCLYGLDADL IMLGLLSHDP HFCLLREEVT FGRHNKNKAR
ELEHQNFYLM HLCIVREYLE LEFQELQEPG KLGFPFDLER VIDDFILMAF FVGNDFLPNL
PRLHINEGAL AAMFRIYKDI LPKGDGYINE GGIINLPRLQ KLLEELGKDE IESFENDASN
EKWFQSKRSA EPNGVDNNKK SKAKGLVLTS SQRDLWKQKI RPYVNKPTSE PLDLGTSLNA
ADRKFVQDLA DTLHIEWSTK EDDDGHRHLL LSFPEGAVES LNDEEEEGTL ALYRVVRNYD
KALVVDITPE DAQRHYQELY DTKYQAWKTK YYLEKFPEWP QESYDKELVK LCENYVQGLQ
WVLHYYYHGI ASWPWFYQYH YSPLTSDVVK GLGADLKFTL GQPFRPYEQL MGVLPDRSKS
IVPEVYWDLM TNPNSPIYDF YPRDFELDMN GKKMEWEAIV KIPFIDEKRL LSAMATKNDQ
LSQQEKSRNG FGVALKFTYN PEVAYTYPSS LVGVFPEISP CHCIENIFEL PNTEGLNFRK
GLVEGAKINI DALAGFPTLH NLPYTAMLVD HYGVNVFQAD SKNPSMIITL TDSEVRTKAE
VAKAKLGKRC FVGYPFLQEA KIVKVSDELF DYELDGRDGS VVTRHHGDRE IREWSKEAAY
IENWHAKRLG FTIGTVESLV QVHMLKGLIK TEEGALIKEY AENPSMRSIY ASQTIVDEVV
NEDERFIEKA AVPIEEEYPV GTQAFFLGEF QYGRALEVTG HANNKANIRV LALKNKEPDF
AKPIIQDMKR QNRYTPSYAV AKMLNLHPLI LSKILSSYQI NTVGGLRVNL GLNLKFDAKK
QKVLGYSQKS DSGWEFSNAA IELLARYIAA FPDFFAAIQQ NPQSSDVSDT DLWKDPKVAA
ARVKEIGAWL KSAQTSKFER VPLDAEQLDS VVVMRLAEEG ANVFTNSHEV EVKNMKGVPR
SAIMKPSDAE LFLSNQRFAL GDRVSFLSSS GKVPLGSRGT VVGLSRTANH VLLDVVWDLT
FMSGTTLGDR CPPFRGMTVY SSSVLNTTHK QVVSGSKAGN LRRPAPPVSS SLTTGAAGVV
QYKDAPAPSP LAGGWRGAVN GSPGHSGRGR GRGGAPNLLH SNLVYRPANG AGEGHEVNGH
GHRSGGTPNG RGRGRGRGGP VQHPGHSGLH ETPQQPMYSN VPPPANLDAR GRGRGRGRGG
RGRGGPRGRG GNGAGAPES
//
