ID T0MY66_9CLOT Unreviewed; 722 AA.
AC T0MY66;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE RecName: Full=Diguanylate cyclase {ECO:0008006|Google:ProtNLM};
GN ORFNames=M918_08445 {ECO:0000313|EMBL:EQB87574.1};
OS Clostridium sp. BL8.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=1354301 {ECO:0000313|EMBL:EQB87574.1, ECO:0000313|Proteomes:UP000015873};
RN [1] {ECO:0000313|EMBL:EQB87574.1, ECO:0000313|Proteomes:UP000015873}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BL8 {ECO:0000313|EMBL:EQB87574.1,
RC ECO:0000313|Proteomes:UP000015873};
RX PubMed=25076986; DOI=10.1186/1757-4749-6-30;
RA Marathe N.P., Shetty S.A., Lanjekar V.B., Rasane M.H., Ranade D.R.,
RA Shouche Y.S.;
RT "Genome sequencing of multidrug resistant novel Clostridium sp. BL8 reveals
RT its potential for pathogenicity.";
RL Gut Pathog. 6:30-30(2014).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EQB87574.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AUPA01000190; EQB87574.1; -; Genomic_DNA.
DR RefSeq; WP_021283951.1; NZ_AUPA01000190.1.
DR AlphaFoldDB; T0MY66; -.
DR STRING; 1354301.M918_08445; -.
DR PATRIC; fig|1354301.3.peg.2842; -.
DR Proteomes; UP000015873; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR CDD; cd01948; EAL; 1.
DR CDD; cd01949; GGDEF; 1.
DR CDD; cd00130; PAS; 2.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 3.20.20.450; EAL domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 2.
DR InterPro; IPR001633; EAL_dom.
DR InterPro; IPR035919; EAL_sf.
DR InterPro; IPR000160; GGDEF_dom.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR001610; PAC.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR000700; PAS-assoc_C.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR NCBIfam; TIGR00254; GGDEF; 1.
DR NCBIfam; TIGR00229; sensory_box; 2.
DR PANTHER; PTHR44757:SF2; BIOFILM ARCHITECTURE MAINTENANCE PROTEIN MBAA; 1.
DR PANTHER; PTHR44757; DIGUANYLATE CYCLASE DGCP; 1.
DR Pfam; PF00563; EAL; 1.
DR Pfam; PF00990; GGDEF; 1.
DR Pfam; PF13426; PAS_9; 2.
DR SMART; SM00052; EAL; 1.
DR SMART; SM00267; GGDEF; 1.
DR SMART; SM00086; PAC; 2.
DR SMART; SM00091; PAS; 2.
DR SUPFAM; SSF141868; EAL domain-like; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2.
DR PROSITE; PS50883; EAL; 1.
DR PROSITE; PS50887; GGDEF; 1.
DR PROSITE; PS50113; PAC; 2.
DR PROSITE; PS50112; PAS; 2.
PE 4: Predicted;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Reference proteome {ECO:0000313|Proteomes:UP000015873}.
FT DOMAIN 47..117
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 120..171
FT /note="PAC"
FT /evidence="ECO:0000259|PROSITE:PS50113"
FT DOMAIN 168..211
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 242..294
FT /note="PAC"
FT /evidence="ECO:0000259|PROSITE:PS50113"
FT DOMAIN 326..459
FT /note="GGDEF"
FT /evidence="ECO:0000259|PROSITE:PS50887"
FT DOMAIN 468..722
FT /note="EAL"
FT /evidence="ECO:0000259|PROSITE:PS50883"
SQ SEQUENCE 722 AA; 82195 MW; D6775BE2210801E3 CRC64;
MRSNLINLIK VFVGEIMKEF DMEQENKESL EKSCECSVEL KKELKDKEQL LNAIFQVTNV
GICVTDESGS FTIVNDAYCK IYGYTREELV GNHFTKIISE ENCEDARKAH DKFFNEGFEM
GREWSVITKD GRVLNVYSSA ALLKQEDGKK YKVTTINDIT EFKETHNKLN LVAYALSSAN
DGIIFTTANP SEILYINEAM VKITGFTLEE LEKQPGGFLK TGPEDHSFYA DMWAKIEKEG
FWQGEIRGRK KNKEEYVAEL NLNRITDSDG ETTNYVAILN EITEKKKVEK RIQYLATYSS
ITNLPNRQHF EGTLSKAIKK HENPHGKLAT VMVDLDRFKN VNDNYSFAMG NKLLRAVAYR
IRNTLKDIAT VAYLGEDHFG ILLDQVLGMN SVCNVTQKIK QALSEPFIFD NVHISITASI
GVSFYRRESK GSEDLISHAE KAIAEAKRLG GDCMQVYTIE MNRKLTRRSQ LENDLKTAIK
NHELFLVYQP QIELQKEQII GVEALIRWKH PTLGMVPPDE FIAIAEETGS ILPIGQWVIK
TAAEQAKKWE TMKLPIKKVA VNLSSVQLKH DHICKVIKEI LEEVDIKPDS LEIELTESTM
MEDIKKSIDI FNSLKQMGLK IAVDDFGTGY SSLSYLRKIP INKLKIDRSF IMDLGSDFEG
SVITKTIIHM AKNLGFKVIA EGTETKEQIQ YLRENGCDEA QGYYYSKPLL PAELEKFVLS
KR
//
