ID T0N6V8_9CLOT Unreviewed; 734 AA.
AC T0N6V8;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=Peptidase S8/S53 domain-containing protein {ECO:0000259|Pfam:PF00082};
GN ORFNames=M918_16600 {ECO:0000313|EMBL:EQB85945.1};
OS Clostridium sp. BL8.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=1354301 {ECO:0000313|EMBL:EQB85945.1, ECO:0000313|Proteomes:UP000015873};
RN [1] {ECO:0000313|EMBL:EQB85945.1, ECO:0000313|Proteomes:UP000015873}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BL8 {ECO:0000313|EMBL:EQB85945.1,
RC ECO:0000313|Proteomes:UP000015873};
RX PubMed=25076986; DOI=10.1186/1757-4749-6-30;
RA Marathe N.P., Shetty S.A., Lanjekar V.B., Rasane M.H., Ranade D.R.,
RA Shouche Y.S.;
RT "Genome sequencing of multidrug resistant novel Clostridium sp. BL8 reveals
RT its potential for pathogenicity.";
RL Gut Pathog. 6:30-30(2014).
CC -!- SIMILARITY: Belongs to the peptidase S8 family. {ECO:0000256|PROSITE-
CC ProRule:PRU01240}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EQB85945.1}.
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DR EMBL; AUPA01000236; EQB85945.1; -; Genomic_DNA.
DR RefSeq; WP_021285536.1; NZ_AUPA01000236.1.
DR AlphaFoldDB; T0N6V8; -.
DR STRING; 1354301.M918_16600; -.
DR PATRIC; fig|1354301.3.peg.4420; -.
DR OrthoDB; 2744137at2; -.
DR Proteomes; UP000015873; Unassembled WGS sequence.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd07478; Peptidases_S8_CspA-like; 1.
DR Gene3D; 2.60.120.1290; -; 1.
DR Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 1.
DR InterPro; IPR034045; Pep_S8_CspA-like.
DR InterPro; IPR000209; Peptidase_S8/S53_dom.
DR InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR InterPro; IPR023827; Peptidase_S8_Asp-AS.
DR InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR PANTHER; PTHR43399; SUBTILISIN-RELATED; 1.
DR PANTHER; PTHR43399:SF4; TK-SUBTILISIN; 1.
DR Pfam; PF00082; Peptidase_S8; 2.
DR PRINTS; PR00723; SUBTILISIN.
DR SUPFAM; SSF52743; Subtilisin-like; 1.
DR PROSITE; PS51892; SUBTILASE; 1.
DR PROSITE; PS00136; SUBTILASE_ASP; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU01240};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Reference proteome {ECO:0000313|Proteomes:UP000015873};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825, ECO:0000256|PROSITE-
KW ProRule:PRU01240}.
FT DOMAIN 193..394
FT /note="Peptidase S8/S53"
FT /evidence="ECO:0000259|Pfam:PF00082"
FT DOMAIN 530..651
FT /note="Peptidase S8/S53"
FT /evidence="ECO:0000259|Pfam:PF00082"
FT REGION 1..64
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9..64
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 202
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 274
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 596
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
SQ SEQUENCE 734 AA; 80835 MW; 4382C8106F641B44 CRC64;
MLQDREAIQP VQPLQQEATL TSPPIVEGQQ AEIPSATEVQ QPTQTTETPP IANESQGEEQ
PKLTQAPTSI LATMDMQPTS NDVPILGGTK DAEGNITGCG DLYLSEAYES YIVEVEQGFY
ESLQNINYAC AFPIGPFSAV LSVQKGRLQQ LIAEARGLIY FQRSYPFTLS ILSPSSVANI
NQFHENEFFK LTGKGTIIAI LDTGIDYLNE EFMTIDKQSR ILEIWDQTIE TGEPPRGFNF
GSIYTETQIN QAIQARREDK DPYAIVPERD TIGHGTSMAG IAAATGIKIP RGAAPECELI
AVKLKYAKAS TLLRSGIIDP MVPVYDAADI ALGIRYLIEA QVRYKKPMVI FLPLSCNFGG
ADGSSGLERF IDYYATRRGI VFVTGSGNQG DTSTHSSGVL RKTGEIRNIE VNIDEAEKIV
HLELYGNSPD RIAIGIVSPS GETIEKVPVK LKGEEIYNLV FEGSTIRVEY AMPEEKTGNE
VIHIFIENSR GGIWQIRVYG EYIVDGRYDC WLPQRELLKG DTRFINPDAY TTVTAPGTAY
NIVTTAFYNQ GNNSIEADSG RGFTRDNRVK PEIATGGIDV VTTFLNNETI TISGSSAAAA
VLSGACALLL EWGVVNGNEP TMYGPTVSSY LIAGANRRIG DIYPNREWGY GTLNLLGTFE
NLRVSGESRF GNENRSADTF QDFIKKDSHS IRGDWSYDKE VSETLYKRIP QEIYNRLRIS
NIGLKIHGRD GDGR
//
