ID T0NKL7_CAMFR Unreviewed; 2063 AA.
AC T0NKL7;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=Paired amphipathic helix protein Sin3a {ECO:0008006|Google:ProtNLM};
GN ORFNames=CB1_000590076 {ECO:0000313|EMBL:EQB78108.1};
OS Camelus ferus (Wild bactrian camel) (Camelus bactrianus ferus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Tylopoda; Camelidae; Camelus.
OX NCBI_TaxID=419612 {ECO:0000313|EMBL:EQB78108.1, ECO:0000313|Proteomes:UP000030684};
RN [1] {ECO:0000313|EMBL:EQB78108.1, ECO:0000313|Proteomes:UP000030684}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=bactrian camel {ECO:0000313|Proteomes:UP000030684};
RX PubMed=23149746;
RG Bactrian Camels Genome Sequencing and Analysis Consortium;
RA Jirimutu, Wang Z., Ding G., Chen G., Sun Y., Sun Z., Zhang H., Wang L.,
RA Hasi S., Zhang Y., Li J., Shi Y., Xu Z., He C., Yu S., Li S., Zhang W.,
RA Batmunkh M., Ts B., Narenbatu, Unierhu, Bat-Ireedui S., Gao H.,
RA Baysgalan B., Li Q., Jia Z., Turigenbayila, Subudenggerile, Narenmanduhu,
RA Wang Z., Wang J., Pan L., Chen Y., Ganerdene Y., Dabxilt, Erdemt, Altansha,
RA Altansukh, Liu T., Cao M., Aruuntsever, Bayart, Hosblig, He F., Zha-ti A.,
RA Zheng G., Qiu F., Sun Z., Zhao L., Zhao W., Liu B., Li C., Chen Y.,
RA Tang X., Guo C., Liu W., Ming L., Temuulen, Cui A., Li Y., Gao J., Li J.,
RA Wurentaodi, Niu S., Sun T., Zhai Z., Zhang M., Chen C., Baldan T.,
RA Bayaer T., Li Y., Meng H.;
RT "Genome sequences of wild and domestic bactrian camels.";
RL Nat. Commun. 3:1202-1202(2012).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00810}.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 38 family.
CC {ECO:0000256|ARBA:ARBA00009792}.
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DR EMBL; KB016863; EQB78108.1; -; Genomic_DNA.
DR Proteomes; UP000030684; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0004559; F:alpha-mannosidase activity; IEA:InterPro.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006013; P:mannose metabolic process; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd10813; GH38N_AMII_Man2C1; 1.
DR Gene3D; 3.20.110.10; Glycoside hydrolase 38, N terminal domain; 1.
DR Gene3D; 1.20.1270.50; Glycoside hydrolase family 38, central domain; 1.
DR Gene3D; 1.20.1160.11; Paired amphipathic helix; 3.
DR InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR InterPro; IPR011330; Glyco_hydro/deAcase_b/a-brl.
DR InterPro; IPR011682; Glyco_hydro_38_C.
DR InterPro; IPR015341; Glyco_hydro_38_cen.
DR InterPro; IPR037094; Glyco_hydro_38_cen_sf.
DR InterPro; IPR000602; Glyco_hydro_38_N.
DR InterPro; IPR027291; Glyco_hydro_38_N_sf.
DR InterPro; IPR028995; Glyco_hydro_57/38_cen_sf.
DR InterPro; IPR013194; HDAC_interact_dom.
DR InterPro; IPR003822; PAH.
DR InterPro; IPR036600; PAH_sf.
DR InterPro; IPR031693; Sin3_C.
DR PANTHER; PTHR46017; ALPHA-MANNOSIDASE 2C1; 1.
DR PANTHER; PTHR46017:SF1; ALPHA-MANNOSIDASE 2C1; 1.
DR Pfam; PF09261; Alpha-mann_mid; 1.
DR Pfam; PF07748; Glyco_hydro_38C; 1.
DR Pfam; PF01074; Glyco_hydro_38N; 1.
DR Pfam; PF02671; PAH; 3.
DR Pfam; PF16879; Sin3a_C; 1.
DR SMART; SM00872; Alpha-mann_mid; 1.
DR SMART; SM00761; HDAC_interact; 1.
DR SUPFAM; SSF88688; Families 57/38 glycoside transferase middle domain; 1.
DR SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR SUPFAM; SSF88713; Glycoside hydrolase/deacetylase; 1.
DR SUPFAM; SSF47762; PAH2 domain; 3.
DR PROSITE; PS51477; PAH; 3.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW Hydrolase {ECO:0000256|ARBA:ARBA00023295};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00810}; Reference proteome {ECO:0000313|Proteomes:UP000030684}.
FT DOMAIN 477..538
FT /note="Histone deacetylase interacting"
FT /evidence="ECO:0000259|SMART:SM00761"
FT DOMAIN 1730..1809
FT /note="Glycoside hydrolase family 38 central"
FT /evidence="ECO:0000259|SMART:SM00872"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 84..113
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 324..370
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 723..752
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1038..1059
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1152..1185
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 791..818
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 334..356
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2063 AA; 233258 MW; 9E325C8D29AC002E CRC64;
MKRRLDDQES PVYAAQQRRI PGSTEAFPHQ HRVLAPAPPV YEAVSETMQS ATGIQYSVTP
SYQVSAVPQS SGSHGPAIAA VHSSHHHPTA VQPHGSQVVQ SHAHPAPPVA PVQGQQQFQR
LKVEDALSYL DQVKLQFGSQ PQVYNDFLDI MKEFKSQSID TPGVISRVSQ LFKGHPDLIM
GFNTFLPPGY KIEVQTNDMV NVTTPGQPHT PVTISLGTAP PLQNNQPVEF NHAINYVNKI
KNRFQGQPDI YKAFLEILHT YQKEQRNAKE AGGNYTPALT EQEVYAQVAR LFKNQEDLLS
EFGQFLPDAN SSVLLSKTTA EKVDSVRNDH GGTVKKPQLN NKPQRPSQNG CQVRRHSGTG
ATPPVKKKPK LLSLKDSSMA DASKHGVGTE SLFFDKVRKA LRSAEAYENF LRCLVIFNQE
VISRAELVQL VSPFLGKFPE LFNWFKNFLG YKESVHLETF PKERATEGIA MEIDYASCKR
LGSSYRALPK SYQQPKCTGR TPLCKELDVV LETNLATIRV LEAIQKKLSR LSAEEQAKFR
LDNTLGGTSE VIHRKALQRI YADKAADIID GLRKNPSIAV PIVLKRLKMK EEEWREAQRG
FNKVWREQNE KYYLKSLDHQ GINFKQNDTK VLRSKSLLNE IESIYDERQE QATEENAGVP
VGPHLSLAYE DKQILEDAAA LIIHHVKRQT GIQKEDKYKI KQIMHHFIPD LLFAQRGDLS
DVEEEEEEEM DVDEATGAAK KHNGVGGSPP KSKLLFSNTA AQKLRGMDEV YNLFYVNNNW
YIFMRLHQIL CLRLLRICSQ AERQIEEENR EREWEREVLG IKRDKSDSPA IQLRLKEPMD
VDVEDYYPAF LDMVRSLLDG NIDSSQYEDS LREMFTIHAY IAFTMDKLIQ SIVRQLQHIV
SDEICVQVTD LYLAENNNGA TGGQLNTQTS RSVLESTYQR KAEQLMSDEN CFKVRVTDAV
RDHTDDSLMF IQSQGQVQLT IELLDTEEEN SDDPVEAERW SDYVERYVNS DTTSPELREH
LARKPVFLPR NLRRIRKCQR GREQQEKEGK EGNSKKAMEN ADSLDKLECR FKLNSYKMVY
VIKSEDYMYR RTALLRAHQS HERVSKRLHQ RFQAWVDKWT KEHVPREMAA ETSKWLMEQQ
GFGEPPVFLG KLPGPGRRPL TPEPLAPGRG PRRQRLRPSG KRSERAAMAA AAAPALKHWR
TTLERVEKFV SPLYFTDCNL RGRLFGDSCP VAELSSFLTP ERLPYQEAVQ QDFRPARVGD
SFGPTWWTCW FRVELTIPEA WVGQEVHLRW ESDGEGLVWR DGEPVQVRSP ALGQGLTKEG
EKTSYVLTDK LEEEDPRSLT LYVEVACNGL LGAGKGSMIA APDPEKMFQV SRAELAVFHR
DVYKLLVDLE LLLGMAKGLG EDNQRSFQAL YTANQIVNVC DPAQPETFPV AQALASKFFG
QRGGESQHTI HAVGHCHIDT AWLWPFKETV RKCARSWVTA IQLMERNPEF IFACSQAQQL
QWVKSYYPGL HARLQEFACR GQFVPVGGTW VEMDGNLPSG EAMVRQFLQG QNFFLQEFGK
MCSEFWLPDT FGYSAQLPQI MRSCGIRHFL TQKLSWNLVN SFPHHTFLWE GLDGSRVLAH
FPPGDSYGMQ GSVEEVLKTV AKNRDKGRTN HSAFLFGFGD GGGGPTQTMV DRLKRLCDTD
GLPRELSGVS SCQSGLDILS ALAWKKRRLF SALEKDSGQL CTWVGELFLE LHNGTYTTHA
QIKKENRECE RILHDAELLS SLALARSAQF LYPAAQLRDL WRLLLLNQFH DVVTGSCIQL
VAEEAMCHYE DIRSHGNTLL SAAAAALCAG EPGPEGLLIV NTLPWKRTEV LALPRPGGAH
SLALVTVPSM GYAPAPTPAS LQPLLPQQPV FVMQETDGSV TLDNGIIRVR LDPTGRLTSL
VLVASGREAI AEGAVGNQFV LFDDVPLYWD AWDVMDYHLE TRKPVLGQAG TLAVGTEGGV
RGSAWFLLQI SPNSRLSQEV VLDVGCPYVR FHTEVHWHEA HKFLKVEFPA RVRSPQATYE
VQFGHLQRPT HYNTSWDWAR FEV
//
