ID   T0PRA6_SAPDV            Unreviewed;       997 AA.
AC   T0PRA6;
DT   16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT   16-OCT-2013, sequence version 1.
DT   27-MAR-2024, entry version 33.
DE   RecName: Full=Lipoxygenase domain-containing protein {ECO:0000259|PROSITE:PS51393};
GN   ORFNames=SDRG_14281 {ECO:0000313|EMBL:EQC28009.1};
OS   Saprolegnia diclina (strain VS20).
OC   Eukaryota; Sar; Stramenopiles; Oomycota; Saprolegniales; Saprolegniaceae;
OC   Saprolegnia.
OX   NCBI_TaxID=1156394 {ECO:0000313|EMBL:EQC28009.1, ECO:0000313|Proteomes:UP000030762};
RN   [1] {ECO:0000313|EMBL:EQC28009.1, ECO:0000313|Proteomes:UP000030762}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=VS20 {ECO:0000313|EMBL:EQC28009.1,
RC   ECO:0000313|Proteomes:UP000030762};
RG   The Broad Institute Genome Sequencing Platform;
RA   Russ C., Nusbaum C., Tyler B., van West P., Dieguez-Uribeondo J.,
RA   de Bruijn I., Tripathy S., Jiang R., Young S.K., Zeng Q., Gargeya S.,
RA   Fitzgerald M., Haas B., Abouelleil A., Alvarado L., Arachchi H.M.,
RA   Berlin A., Chapman S.B., Goldberg J., Griggs A., Gujja S., Hansen M.,
RA   Howarth C., Imamovic A., Larimer J., McCowen C., Montmayeur A., Murphy C.,
RA   Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T., Sisk P.,
RA   Sykes S., Wortman J., Nusbaum C., Birren B.;
RT   "The Genome Sequence of Saprolegnia declina VS20.";
RL   Submitted (APR-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the cytochrome P450 family.
CC       {ECO:0000256|ARBA:ARBA00010617}.
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DR   EMBL; JH767200; EQC28009.1; -; Genomic_DNA.
DR   RefSeq; XP_008618622.1; XM_008620400.1.
DR   AlphaFoldDB; T0PRA6; -.
DR   STRING; 1156394.T0PRA6; -.
DR   EnsemblProtists; EQC28009; EQC28009; SDRG_14281.
DR   GeneID; 19955008; -.
DR   VEuPathDB; FungiDB:SDRG_14281; -.
DR   eggNOG; KOG0157; Eukaryota.
DR   InParanoid; T0PRA6; -.
DR   OMA; CRTFAND; -.
DR   OrthoDB; 45595at2759; -.
DR   Proteomes; UP000030762; Unassembled WGS sequence.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0004497; F:monooxygenase activity; IEA:InterPro.
DR   GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
DR   GO; GO:0016702; F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; IEA:InterPro.
DR   Gene3D; 1.10.630.10; Cytochrome P450; 1.
DR   InterPro; IPR001128; Cyt_P450.
DR   InterPro; IPR036396; Cyt_P450_sf.
DR   InterPro; IPR013819; LipOase_C.
DR   InterPro; IPR036226; LipOase_C_sf.
DR   PANTHER; PTHR24286; CYTOCHROME P450 26; 1.
DR   PANTHER; PTHR24286:SF24; LANOSTEROL 14-ALPHA DEMETHYLASE; 1.
DR   Pfam; PF00305; Lipoxygenase; 1.
DR   Pfam; PF00067; p450; 1.
DR   SUPFAM; SSF48264; Cytochrome P450; 1.
DR   SUPFAM; SSF48484; Lipoxigenase; 1.
DR   PROSITE; PS51393; LIPOXYGENASE_3; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000030762}.
FT   DOMAIN          701..864
FT                   /note="Lipoxygenase"
FT                   /evidence="ECO:0000259|PROSITE:PS51393"
SQ   SEQUENCE   997 AA;  111481 MW;  26371ECA0336575F CRC64;
     MGSQASTPAG AAPSLRRAAS LKKMIMFMKD PRTAMMDCRD HYGDVFLMES SLVNEKIMGF
     CGPEALLAYD TQVKEGKIVR ASAFPTGILE LLGAVVSTLD DDAHAKRKAA LLVAFTPEKL
     DAYKPKIREI IQHDHAAWAA RGGSLSLALS CKKMVFHVFM ATLLGLENVD DEYRELVEAF
     VSSIRKSARK PDTTGMDART QVVEELIRPA VREAKARVAA QKPLPTVVEV LVADGRLSDE
     ELNLELFHAL FAGLGGVTCL VINAVTACIE LPAIREKVSA AREAFLAKYP NEDDRWSHFA
     DLGYMHHFIL EVKRFYVAGP TQLYGRATDD LEISTANGSF KVPKGCLATA GLEVTSKHPD
     VWSDPHTFNP DRFAPQDAST TPVDPDAFKD GARDVTAPDM MYKFCPHSIG IARRCAGEGL
     TTLVLQCFVV SLFDFIWQMV PGQNYQLEEK SSTPTPIGQL MAVGFHRRTL DDVVTFGTAG
     SDEDWHFLSL PQAKELVGSG TADLYDDARM DLWTRLMIKL IGKKQATWDR PFVESCLTIP
     KHQKVLPKLT LIQTSIEIPT EDEDWPKQPW LEIKQSNFLR DHAPFIDDFK HTWLPGEDME
     RYVMSKLGHM WPRVNVHWND RYSDRALELL AFNGLGQHLL MKLPEAHDDG SYYGICLDFM
     NVLEVRPGYA KYGADAYFTA KGKVTKIIRG GVTSRPGEDG WEYAKLCFRG SLQTKVTAVD
     HLLGIHATVA NYMVTSIREQ LPPAHPVRRL LKPFTFRSVA INFGAGRSLF WPKGMLQRAY
     ALTDKGMKQT WEYGLANFKY ETFPERKARQ SIDTVTLPFH EDGIEYWQIC RTFANDYVDL
     YYKSEDATSA DADLKRFWTF LDEKLPFTMR PLNLENLKDF LAHGIFLVSS MHNHLGTIAE
     YVSDPAFCPS AWVEGELAGR PGTGVRLALI MTATGFTQPD ITEDFSHLML DDAAKAVCKA
     FTAAVIAQIA VVDARNATRV QPFQSFNPKT MEMAVSI
//