ID T0QKA7_SAPDV Unreviewed; 851 AA.
AC T0QKA7;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=Peptidase M28 domain-containing protein {ECO:0000259|Pfam:PF04389};
GN ORFNames=SDRG_08408 {ECO:0000313|EMBL:EQC34205.1};
OS Saprolegnia diclina (strain VS20).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Saprolegniales; Saprolegniaceae;
OC Saprolegnia.
OX NCBI_TaxID=1156394 {ECO:0000313|EMBL:EQC34205.1, ECO:0000313|Proteomes:UP000030762};
RN [1] {ECO:0000313|EMBL:EQC34205.1, ECO:0000313|Proteomes:UP000030762}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VS20 {ECO:0000313|EMBL:EQC34205.1,
RC ECO:0000313|Proteomes:UP000030762};
RG The Broad Institute Genome Sequencing Platform;
RA Russ C., Nusbaum C., Tyler B., van West P., Dieguez-Uribeondo J.,
RA de Bruijn I., Tripathy S., Jiang R., Young S.K., Zeng Q., Gargeya S.,
RA Fitzgerald M., Haas B., Abouelleil A., Alvarado L., Arachchi H.M.,
RA Berlin A., Chapman S.B., Goldberg J., Griggs A., Gujja S., Hansen M.,
RA Howarth C., Imamovic A., Larimer J., McCowen C., Montmayeur A., Murphy C.,
RA Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T., Sisk P.,
RA Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Saprolegnia declina VS20.";
RL Submitted (APR-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004477}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; JH767156; EQC34205.1; -; Genomic_DNA.
DR RefSeq; XP_008612517.1; XM_008614295.1.
DR AlphaFoldDB; T0QKA7; -.
DR STRING; 1156394.T0QKA7; -.
DR EnsemblProtists; EQC34205; EQC34205; SDRG_08408.
DR GeneID; 19949135; -.
DR VEuPathDB; FungiDB:SDRG_08408; -.
DR eggNOG; KOG2194; Eukaryota.
DR InParanoid; T0QKA7; -.
DR OMA; HFWIEAE; -.
DR OrthoDB; 277019at2759; -.
DR Proteomes; UP000030762; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008235; F:metalloexopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd03875; M28_Fxna_like; 1.
DR Gene3D; 3.40.630.10; Zn peptidases; 1.
DR InterPro; IPR048024; Fxna-like_M28_dom.
DR InterPro; IPR045175; M28_fam.
DR InterPro; IPR007484; Peptidase_M28.
DR PANTHER; PTHR12147:SF26; ENDOPLASMIC RETICULUM METALLOPEPTIDASE 1; 1.
DR PANTHER; PTHR12147; METALLOPEPTIDASE M28 FAMILY MEMBER; 1.
DR Pfam; PF04389; Peptidase_M28; 1.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
PE 4: Predicted;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00023049};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000030762};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 30..51
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 382..402
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 414..436
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 484..511
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 532..560
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 572..596
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 608..626
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 149..338
FT /note="Peptidase M28"
FT /evidence="ECO:0000259|Pfam:PF04389"
SQ SEQUENCE 851 AA; 92794 MW; 77B95F67C7CB9CE1 CRC64;
MHQRKQQPPT RPLADAVDRP NDDAVKPVRA YFLSAWAIVA WLCLLYGFVF WRHTWLPSPK
DASIPLTEFS EERARRFLEE LQAIEGGYRT LGSVANEVAT PAWLLRHLEA FQAQCHSPCN
MEIEVQKPEG AFGLNFLAQF QNIYANVTNV LVRLSASPEA SPPSLLLSSH YDAAIGAAAA
SDDGVNIAIM LELLQNAVAR PPTATALVFN FNGAEETFLQ ASHGFITQHP WRASVAAFLN
LEAAGAGGRE LLFQTGSDVL AMAYAHGAPY PHASTIAQEV FQSGVIPGET DYRTYTEYGD
VPGMDFAYVA NGYVYHTPLD DISRIQLGAI QRFGENVQGT IAQLFASPAT LRSLGAQSSL
GGHIFFDVFG YRTLTLSTEV STFIHAALAL CMLLYVGLVS RITWREKLDA VRLLVRLSLA
GLGTGLLVAL VLCAYAPMSW FASPTTRLWV FVFPVAAGFL HQLPTDDAVA LRSLVQPLVE
AQSLMWLLVM ALPMFARGIQ SLYLVMAWVM CPLAAQVVAQ SLPTGYSPRV HAGLLLAGIA
VPLLHSVQIY IVALQVFIPI MGRAGTSLPS DLVVALLMAL LSLLTLSALT PVLCFVRPLH
AAHAKTSAIA LTLLCIFVAC VSNPYSTECP KRIIVQHIHR NFTQRPDAND AGLWVLGFDF
QGLDPLRAAF GTTPWALAMH APVHDAAIPV VYDNFPWVYP VAPVMPLKNT WYLPTMDAPV
FAVPTLLEVV SSRVDPMTRL RRLHLHLSGP SQINMYMDAS RTKLASWSLG NGTDGVPSQI
DDVYLFQFST GGLAPASFHF WVDVATDGPI DVAYCGHYLN GTTPDLATAA KLLPDWTAHT
TFTSSWTLTQ L
//
