ID   T0QTA6_SAPDV            Unreviewed;       248 AA.
AC   T0QTA6;
DT   16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT   16-OCT-2013, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   RecName: Full=Defective in cullin neddylation protein {ECO:0000256|RuleBase:RU410713};
GN   ORFNames=SDRG_05470 {ECO:0000313|EMBL:EQC37245.1};
OS   Saprolegnia diclina (strain VS20).
OC   Eukaryota; Sar; Stramenopiles; Oomycota; Saprolegniales; Saprolegniaceae;
OC   Saprolegnia.
OX   NCBI_TaxID=1156394 {ECO:0000313|EMBL:EQC37245.1, ECO:0000313|Proteomes:UP000030762};
RN   [1] {ECO:0000313|EMBL:EQC37245.1, ECO:0000313|Proteomes:UP000030762}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=VS20 {ECO:0000313|EMBL:EQC37245.1,
RC   ECO:0000313|Proteomes:UP000030762};
RG   The Broad Institute Genome Sequencing Platform;
RA   Russ C., Nusbaum C., Tyler B., van West P., Dieguez-Uribeondo J.,
RA   de Bruijn I., Tripathy S., Jiang R., Young S.K., Zeng Q., Gargeya S.,
RA   Fitzgerald M., Haas B., Abouelleil A., Alvarado L., Arachchi H.M.,
RA   Berlin A., Chapman S.B., Goldberg J., Griggs A., Gujja S., Hansen M.,
RA   Howarth C., Imamovic A., Larimer J., McCowen C., Montmayeur A., Murphy C.,
RA   Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T., Sisk P.,
RA   Sykes S., Wortman J., Nusbaum C., Birren B.;
RT   "The Genome Sequence of Saprolegnia declina VS20.";
RL   Submitted (APR-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Neddylation of cullins play an essential role in the
CC       regulation of SCF-type complexes activity.
CC       {ECO:0000256|RuleBase:RU410713}.
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DR   EMBL; JH767145; EQC37245.1; -; Genomic_DNA.
DR   RefSeq; XP_008609407.1; XM_008611185.1.
DR   AlphaFoldDB; T0QTA6; -.
DR   STRING; 1156394.T0QTA6; -.
DR   EnsemblProtists; EQC37245; EQC37245; SDRG_05470.
DR   GeneID; 19946197; -.
DR   VEuPathDB; FungiDB:SDRG_05470; -.
DR   eggNOG; KOG3077; Eukaryota.
DR   InParanoid; T0QTA6; -.
DR   OMA; NMDQWLS; -.
DR   OrthoDB; 169757at2759; -.
DR   Proteomes; UP000030762; Unassembled WGS sequence.
DR   Gene3D; 1.10.238.200; Cullin, PONY binding domain; 1.
DR   Gene3D; 1.10.8.10; DNA helicase RuvA subunit, C-terminal domain; 1.
DR   Gene3D; 1.10.238.10; EF-hand; 1.
DR   InterPro; IPR014764; DCN-prot.
DR   InterPro; IPR042460; DCN1-like_PONY.
DR   InterPro; IPR005176; PONY_dom.
DR   InterPro; IPR009060; UBA-like_sf.
DR   PANTHER; PTHR12281:SF31; DCN1-LIKE PROTEIN 3; 1.
DR   PANTHER; PTHR12281; RP42 RELATED; 1.
DR   Pfam; PF03556; Cullin_binding; 1.
DR   Pfam; PF14555; UBA_4; 1.
DR   SUPFAM; SSF46934; UBA-like; 1.
DR   PROSITE; PS51229; DCUN1; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000030762};
KW   Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT   DOMAIN          56..244
FT                   /note="DCUN1"
FT                   /evidence="ECO:0000259|PROSITE:PS51229"
SQ   SEQUENCE   248 AA;  28212 MW;  061A402328C9B7C6 CRC64;
     MSLNSKQETL VKSLVDFTSC SRTEAIALLK KHAWNVSTAA DKYYEENANI ASLTIVNEAT
     IAAWFDTYAD YDDPDCMLDD GILKFCDDIG IDAQDIVVLV IAWKMQAAAM CTFTKKEFVQ
     GMKEMGCESA SQVAAKLPGL RALLADPQSF KPFYSFCFLY SKDQGQKSLS KEMAIAMWEL
     VLAERFPKTK DWIAFLEKHN SHGVTRDTWD LFFDFMLKVE TSYDAYDENE AWPVLIDDFM
     THIEAQKK
//