ID   T0R438_SAPDV            Unreviewed;       822 AA.
AC   T0R438;
DT   16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT   16-OCT-2013, sequence version 1.
DT   24-JAN-2024, entry version 35.
DE   RecName: Full=PH domain-containing protein {ECO:0008006|Google:ProtNLM};
GN   ORFNames=SDRG_02154 {ECO:0000313|EMBL:EQC41105.1};
OS   Saprolegnia diclina (strain VS20).
OC   Eukaryota; Sar; Stramenopiles; Oomycota; Saprolegniales; Saprolegniaceae;
OC   Saprolegnia.
OX   NCBI_TaxID=1156394 {ECO:0000313|EMBL:EQC41105.1, ECO:0000313|Proteomes:UP000030762};
RN   [1] {ECO:0000313|EMBL:EQC41105.1, ECO:0000313|Proteomes:UP000030762}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=VS20 {ECO:0000313|EMBL:EQC41105.1,
RC   ECO:0000313|Proteomes:UP000030762};
RG   The Broad Institute Genome Sequencing Platform;
RA   Russ C., Nusbaum C., Tyler B., van West P., Dieguez-Uribeondo J.,
RA   de Bruijn I., Tripathy S., Jiang R., Young S.K., Zeng Q., Gargeya S.,
RA   Fitzgerald M., Haas B., Abouelleil A., Alvarado L., Arachchi H.M.,
RA   Berlin A., Chapman S.B., Goldberg J., Griggs A., Gujja S., Hansen M.,
RA   Howarth C., Imamovic A., Larimer J., McCowen C., Montmayeur A., Murphy C.,
RA   Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T., Sisk P.,
RA   Sykes S., Wortman J., Nusbaum C., Birren B.;
RT   "The Genome Sequence of Saprolegnia declina VS20.";
RL   Submitted (APR-2012) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; JH767135; EQC41105.1; -; Genomic_DNA.
DR   RefSeq; XP_008605949.1; XM_008607727.1.
DR   AlphaFoldDB; T0R438; -.
DR   STRING; 1156394.T0R438; -.
DR   EnsemblProtists; EQC41105; EQC41105; SDRG_02154.
DR   GeneID; 19942881; -.
DR   VEuPathDB; FungiDB:SDRG_02154; -.
DR   eggNOG; ENOG502S5U0; Eukaryota.
DR   InParanoid; T0R438; -.
DR   OMA; HRGWICK; -.
DR   OrthoDB; 55140at2759; -.
DR   Proteomes; UP000030762; Unassembled WGS sequence.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   Gene3D; 3.30.60.90; -; 3.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR000433; Znf_ZZ.
DR   InterPro; IPR043145; Znf_ZZ_sf.
DR   PANTHER; PTHR20930; OVARIAN CARCINOMA ANTIGEN CA125-RELATED; 1.
DR   PANTHER; PTHR20930:SF0; PROTEIN ILRUN; 1.
DR   Pfam; PF00169; PH; 1.
DR   Pfam; PF00569; ZZ; 3.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00291; ZnF_ZZ; 3.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   SUPFAM; SSF57850; RING/U-box; 3.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
DR   PROSITE; PS50135; ZF_ZZ_2; 2.
PE   4: Predicted;
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000030762};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW   ProRule:PRU00228}.
FT   DOMAIN          123..217
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   DOMAIN          543..596
FT                   /note="ZZ-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50135"
FT   DOMAIN          597..648
FT                   /note="ZZ-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50135"
FT   REGION          220..293
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          717..744
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        220..255
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   822 AA;  87879 MW;  7683D0B6FFE99CEF CRC64;
     MAAIGDVTVG FRKGANGQLH MGLELQQGNE RELISKAILD QLYAAHRDLQ PRVDGLFTAL
     MHMNGAFEKH GYDGWRITST GEVISDVASD QTVVATFNAK LQDLNGFIVH HKQRARSVSA
     PPTRDHRGWI CKQGSVVKNW KRRFMVLQSC HLHYFETDKL TPTLKPKGSF QVLAIERASD
     LQHGLVAKGS GNRVFKFYAD DAQSCTAWFT AIVSHLRSRP TVTPSASAPN LSSPARSLSA
     SSASSSSSAP TPQPPRRAST AALPAPLSAP TVTPAAPQKE TPASAPGPPV AKRLPIATPV
     SQAAAIKPPV APTKPSPVKH LVHAPSAPSL AAPKKVDIAS VLVALAKQPT GALSMSLKTT
     EGVTYRVVVA TELNAIYAQH PRFKPLVDGL FTAMSRLNER LRSRQYSGWA LTSTGTVECS
     YSPTEAAAFN AALQSVNQYI VRQKHAHLGR APSTGNIAAP APSASNNNNN NIDNVARTVA
     ANVPVGLAAN LVSVFVSEEL GKAIQAVAPV LEAGQAALKE QERQESKRSA PMAAAPPRLA
     QVHTGIMCDG CKVTPITGPR YQSTKYATID VCGRCVQSPA VQTTWGPFQE MRQTVVHPNV
     ACDGCGTNPI AGTRFISKKT PNFDCCERCV GRLHTAHGPF DAVARPRVLT THINITCDGC
     RLGPIRGARF ASTRVANFDL CHMCTRSRRF EASHGPFRRV GNRNEKNERG ETVTIEVQTG
     GPARDMSESN HYDDYDDDEG MYESNDGTFA GDDGSNFAGG DLFAGDSGVN GVDTSGAFGF
     ENAMGYADDS GGASSMFSQL GLDNNSVDVS SWFDVSNFSY DF
//