ID T0S0U5_SAPDV Unreviewed; 506 AA.
AC T0S0U5;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE RecName: Full=RING-type E3 ubiquitin transferase BRCA1 {ECO:0008006|Google:ProtNLM};
GN ORFNames=SDRG_04254 {ECO:0000313|EMBL:EQC38548.1};
OS Saprolegnia diclina (strain VS20).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Saprolegniales; Saprolegniaceae;
OC Saprolegnia.
OX NCBI_TaxID=1156394 {ECO:0000313|EMBL:EQC38548.1, ECO:0000313|Proteomes:UP000030762};
RN [1] {ECO:0000313|EMBL:EQC38548.1, ECO:0000313|Proteomes:UP000030762}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VS20 {ECO:0000313|EMBL:EQC38548.1,
RC ECO:0000313|Proteomes:UP000030762};
RG The Broad Institute Genome Sequencing Platform;
RA Russ C., Nusbaum C., Tyler B., van West P., Dieguez-Uribeondo J.,
RA de Bruijn I., Tripathy S., Jiang R., Young S.K., Zeng Q., Gargeya S.,
RA Fitzgerald M., Haas B., Abouelleil A., Alvarado L., Arachchi H.M.,
RA Berlin A., Chapman S.B., Goldberg J., Griggs A., Gujja S., Hansen M.,
RA Howarth C., Imamovic A., Larimer J., McCowen C., Montmayeur A., Murphy C.,
RA Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T., Sisk P.,
RA Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Saprolegnia declina VS20.";
RL Submitted (APR-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; JH767141; EQC38548.1; -; Genomic_DNA.
DR RefSeq; XP_008608140.1; XM_008609918.1.
DR AlphaFoldDB; T0S0U5; -.
DR STRING; 1156394.T0S0U5; -.
DR EnsemblProtists; EQC38548; EQC38548; SDRG_04254.
DR GeneID; 19944981; -.
DR VEuPathDB; FungiDB:SDRG_04254; -.
DR eggNOG; KOG4362; Eukaryota.
DR InParanoid; T0S0U5; -.
DR OMA; ECALKPL; -.
DR OrthoDB; 51643at2759; -.
DR Proteomes; UP000030762; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR CDD; cd17734; BRCT_Bard1_rpt1; 1.
DR Gene3D; 3.40.50.10190; BRCT domain; 2.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR031099; BRCA1-associated.
DR InterPro; IPR001357; BRCT_dom.
DR InterPro; IPR036420; BRCT_dom_sf.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR13763:SF0; BREAST CANCER TYPE 1 SUSCEPTIBILITY PROTEIN; 1.
DR PANTHER; PTHR13763; BREAST CANCER TYPE 1 SUSCEPTIBILITY PROTEIN BRCA1; 1.
DR Pfam; PF00533; BRCT; 1.
DR Pfam; PF13923; zf-C3HC4_2; 1.
DR SMART; SM00292; BRCT; 2.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF52113; BRCT domain; 2.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50172; BRCT; 2.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000030762};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 20..58
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 258..368
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT DOMAIN 402..505
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT REGION 209..257
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 209..238
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 506 AA; 54721 MW; E8344362F2AABED8 CRC64;
MVLHAAVARA LDAFATQMRC PICLEALSRP FSLPCNHFFC EACIHTALGF ATTCPVCKAM
VRKRTLRHDT SVQRIQDALQ KLMAMRPAIE APVPAVTVPT SICIDLCSEE SEYEQSNSVT
QATQIDAPPL VPVVAPETEV HNAILSPERP PQTEVFTGGQ VVEVSARTWP GINKLGGTAW
IVRRNDDGTY NVKYVLGGRE GRVDPVYIRS AGTSNNDNNS SDDARTSPAP SSARTIPSRK
RLSPAIESPP PAAPKKAKKA VHIREALVFL CSGLNHDEKT LVESCAQLVG ATTVHEWTES
VTHVIVKCQH AAPMRQKLQL SDKVNRWVKI RSIKYLKAVV SGRWIVSDAW IQACVKAKGL
VSEETYEVQG LLKVQHVPEI AKKARLLRQA NLATATGVPS AVGTRLFASL VCVVYGNFAS
PLPPKHEIGS LVRLGDGTIV SSLDDLVKAA AQTSSRTCVV IVEAMDVVLP LPTTAAGLTI
YAVGYEWVLD SVSECALKPL AHLLQT
//
