ID T0S217_SAPDV Unreviewed; 1452 AA.
AC T0S217;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN ORFNames=SDRG_05659 {ECO:0000313|EMBL:EQC36827.1};
OS Saprolegnia diclina (strain VS20).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Saprolegniales; Saprolegniaceae;
OC Saprolegnia.
OX NCBI_TaxID=1156394 {ECO:0000313|EMBL:EQC36827.1, ECO:0000313|Proteomes:UP000030762};
RN [1] {ECO:0000313|EMBL:EQC36827.1, ECO:0000313|Proteomes:UP000030762}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VS20 {ECO:0000313|EMBL:EQC36827.1,
RC ECO:0000313|Proteomes:UP000030762};
RG The Broad Institute Genome Sequencing Platform;
RA Russ C., Nusbaum C., Tyler B., van West P., Dieguez-Uribeondo J.,
RA de Bruijn I., Tripathy S., Jiang R., Young S.K., Zeng Q., Gargeya S.,
RA Fitzgerald M., Haas B., Abouelleil A., Alvarado L., Arachchi H.M.,
RA Berlin A., Chapman S.B., Goldberg J., Griggs A., Gujja S., Hansen M.,
RA Howarth C., Imamovic A., Larimer J., McCowen C., Montmayeur A., Murphy C.,
RA Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T., Sisk P.,
RA Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Saprolegnia declina VS20.";
RL Submitted (APR-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00000600};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:13066;
CC Evidence={ECO:0000256|ARBA:ARBA00000600};
CC -!- SIMILARITY: Belongs to the DNA2/NAM7 helicase family. SDE3 subfamily.
CC {ECO:0000256|ARBA:ARBA00005601}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JH767146; EQC36827.1; -; Genomic_DNA.
DR RefSeq; XP_008609608.1; XM_008611386.1.
DR STRING; 1156394.T0S217; -.
DR EnsemblProtists; EQC36827; EQC36827; SDRG_05659.
DR GeneID; 19946386; -.
DR VEuPathDB; FungiDB:SDRG_05659; -.
DR eggNOG; KOG1804; Eukaryota.
DR eggNOG; KOG2405; Eukaryota.
DR InParanoid; T0S217; -.
DR OMA; LFELHAV; -.
DR OrthoDB; 170190at2759; -.
DR Proteomes; UP000030762; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR GO; GO:0032574; F:5'-3' RNA helicase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0006139; P:nucleobase-containing compound metabolic process; IEA:InterPro.
DR CDD; cd18038; DEXXQc_Helz-like; 1.
DR CDD; cd18808; SF1_C_Upf1; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR002562; 3'-5'_exonuclease_dom.
DR InterPro; IPR045055; DNA2/NAM7-like.
DR InterPro; IPR041679; DNA2/NAM7-like_C.
DR InterPro; IPR041677; DNA2/NAM7_AAA_11.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR049080; MOV-10-like_beta-barrel.
DR InterPro; IPR026122; MOV-10/SDE3_DEXXQ/H-box.
DR InterPro; IPR049077; MOV-10_Ig-like.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR047187; SF1_C_Upf1.
DR PANTHER; PTHR10887; DNA2/NAM7 HELICASE FAMILY; 1.
DR PANTHER; PTHR10887:SF322; RNA HELICASE MOV10L1; 1.
DR Pfam; PF13086; AAA_11; 2.
DR Pfam; PF13087; AAA_12; 1.
DR Pfam; PF01612; DNA_pol_A_exo1; 1.
DR Pfam; PF21634; MOV-10_beta-barrel; 1.
DR Pfam; PF21633; MOV-10_Ig-like; 1.
DR SMART; SM00474; 35EXOc; 1.
DR SMART; SM00487; DEXDc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000030762}.
FT DOMAIN 891..1066
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT REGION 670..703
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1310..1332
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1452 AA; 158310 MW; 46792DCEA590B577 CRC64;
MAAKACVDAL CDYVRAHHGY VRVANIEAFY SSTKPRKKHK VTVTAAGGVE AFIAAHGASA
AYPLAVAAHA IQFAATSEAI KALGEASLNR ATTDIGCFLG VFRQAHRAYG FMWTTTKIAS
CTEFIEIHGC LDQFQLAIVG GKKLLDITWT RQAVSPPPTT TPPAAAVPPA PYKYITTVQG
AKQAFAVLKQ LDVLFMDLEG DLEATGKMSL LQVSCRSDCV YILDVYTCPA ILREPEIVAV
LTSKLAVLHD ARHDYMGLAG QFNLRLTNLF DTQVAHQVLT SSPNTLMGLN KILHQYAGAI
NTQKDSVQHG FGLWDRRPIE AQRLDYAAQD VKHLPAAYAR MKSLMTTDMY NDVLSKSLAR
AQLGAVPQGA HDAMRRLGKY IVSLGGKLPL TKMGDYYTKH PNDKGVFKPS ISTFLRKHGP
QASPPILVDG DVAWVEDGTK PLTVASVLKI LGGFIAENGG RIPGSHLGVL YKEYPGISAV
IFANGGNASG FVKAHGASAT PPIRCTDGDF FVGNQAASPA DDPSPAKLFK LYGAKFTADK
YGVEITDDGA FRNVVETKTS ATQFYKVTNR ATESITLRRV FQVATSKGST PFKFGPKIGT
NIVFAPNTEL SIPCHFSPKV PGQYKTILAF EFVTRQGTVV FIGRVVEGVN AIDASMDAET
RAAIAAAPVK RQRRKQRANL HFVPPNGGDK HSAKSTKSKR NVPLASYPVP SPLPAVDFDG
PLSLVNYQVR LRHLLYHEEL EHLRQQAEFD MDGARLKFKT PDLYELAVPG LAEGRPSLMT
GDKVWLSRGA KTFQGTVSDV RLDAIYIATP TSFRSAYQAG AAFNVRFIMS RTPMREMHQG
LANISLAMHE MLLFPSPAVP NAVRSQRSLQ PTRPINPEQR KVVDDVLDHV VSSAKVKAPY
LLFGPPGTGK TVTLVETIVQ LLRAKPDAKI LVCAPSNAAA DNVVERLAPQ LTPAKLLRAM
AFSRRVKGTP DAVLPFTKTN GEGGFTPVTL SDVKAVSVIV STIGSGAKLY NLGVTRGYFS
LIAIDEAAQA SEPEVITVLG PLALTGTAVV LAGDPMQLGP VIKSDVAAKH GLSMSLMERL
MQRELYATSH KTKLLRNYRS HEAILTVPNA LFYDGELTPH APKSASHNML AWPSLPNAAA
PILFHGITGA EMQDADSPSW YNLFELHAVL TYIQSLKSYP GLRLDEIGVI TPYAKQRQKI
QMALQKHKLD GVQVGSVEQF QGGERRVILV STVRSSTEFF ADDAKFRLGF VSHPKRFNVA
ITRAKALLIV VGNPNILETS QTWAPFLEHC VRLGAVAGAP PMRATAMVKA EHANDSDYDS
NADDNDDDDD YDSDDDVCVQ YEIMMAEAAA AHRANVQADA VARAARVEEE RAYRARLHAW
EDARARELAL REQARQRDVY NAVMEQQYRA QREYEERMYR NARAQEHAAM MAAQEAARQA
KHDESTSGCS IQ
//
