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Database: UniProt
Entry: T0SAS6_LACLC
LinkDB: T0SAS6_LACLC
Original site: T0SAS6_LACLC 
ID   T0SAS6_LACLC            Unreviewed;       691 AA.
AC   T0SAS6;
DT   16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT   16-OCT-2013, sequence version 1.
DT   11-DEC-2019, entry version 27.
DE   RecName: Full=Ferrous iron transport protein B {ECO:0000256|RuleBase:RU362098};
GN   ORFNames=LLT6_08715 {ECO:0000313|EMBL:EQC56137.1};
OS   Lactococcus lactis subsp. cremoris TIFN6.
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Lactococcus.
OX   NCBI_TaxID=1234876 {ECO:0000313|EMBL:EQC56137.1, ECO:0000313|Proteomes:UP000015854};
RN   [1] {ECO:0000313|EMBL:EQC56137.1, ECO:0000313|Proteomes:UP000015854}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TIFN6 {ECO:0000313|EMBL:EQC56137.1,
RC   ECO:0000313|Proteomes:UP000015854};
RX   PubMed=23823494; DOI=10.1038/ismej.2013.108;
RA   Erkus O., de Jager V.C., Spus M., van Alen-Boerrigter I.J.,
RA   van Rijswijck I.M., Hazelwood L., Janssen P.W., van Hijum S.A.,
RA   Kleerebezem M., Smid E.J.;
RT   "Multifactorial diversity sustains microbial community stability.";
RL   ISME J. 7:2126-2136(2013).
CC   -!- FUNCTION: Probable transporter of a GTP-driven Fe(2+) uptake system.
CC       {ECO:0000256|RuleBase:RU362098}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU362098}.
CC   -!- SIMILARITY: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like
CC       GTPase superfamily. FeoB GTPase (TC 9.A.8) family.
CC       {ECO:0000256|RuleBase:RU362098}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EQC56137.1}.
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DR   EMBL; ATBB01000356; EQC56137.1; -; Genomic_DNA.
DR   EnsemblBacteria; EQC56137; EQC56137; LLT6_08715.
DR   PATRIC; fig|1234876.3.peg.1549; -.
DR   Proteomes; UP000015854; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015093; F:ferrous iron transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0055072; P:iron ion homeostasis; IEA:UniProtKB-KW.
DR   CDD; cd01879; FeoB; 1.
DR   InterPro; IPR003373; Fe2_transport_prot-B.
DR   InterPro; IPR011640; Fe2_transport_prot_B_C.
DR   InterPro; IPR041069; FeoB_Cyto.
DR   InterPro; IPR030389; G_FEOB_dom.
DR   InterPro; IPR011642; Gate_dom.
DR   InterPro; IPR006073; GTP_binding_domain.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF07664; FeoB_C; 1.
DR   Pfam; PF17910; FeoB_Cyto; 1.
DR   Pfam; PF02421; FeoB_N; 1.
DR   Pfam; PF07670; Gate; 2.
DR   PRINTS; PR00326; GTP1OBG.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00437; feoB; 1.
DR   PROSITE; PS51711; G_FEOB; 1.
PE   3: Inferred from homology;
KW   GTP-binding {ECO:0000256|RuleBase:RU362098};
KW   Ion transport {ECO:0000256|RuleBase:RU362098};
KW   Iron {ECO:0000256|RuleBase:RU362098};
KW   Iron transport {ECO:0000256|RuleBase:RU362098};
KW   Membrane {ECO:0000256|RuleBase:RU362098};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU362098};
KW   Transmembrane {ECO:0000256|RuleBase:RU362098};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU362098};
KW   Transport {ECO:0000256|RuleBase:RU362098}.
FT   TRANSMEM        269..286
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362098"
FT   TRANSMEM        331..356
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362098"
FT   TRANSMEM        376..399
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362098"
FT   TRANSMEM        441..461
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362098"
FT   TRANSMEM        500..518
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362098"
FT   TRANSMEM        530..551
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362098"
FT   TRANSMEM        558..579
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362098"
FT   TRANSMEM        599..622
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362098"
FT   TRANSMEM        634..657
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362098"
FT   TRANSMEM        663..680
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362098"
FT   DOMAIN          1..162
FT                   /note="FeoB-type G"
FT                   /evidence="ECO:0000259|PROSITE:PS51711"
SQ   SEQUENCE   691 AA;  76456 MW;  6BA835A0DAE9AD45 CRC64;
     MKIIALLGNP NSGKTSIFNL LTGSNQQVGN WPGVTVEKKS GIYRKDKNVC IQDLPGLYSL
     SPYSLDEQVA RDFLVKTPPD ALINIVDSTN LERSLYLTLQ LMEFGIPMVL ALNMSDLLEN
     QGKKIDLEKL SYSLGIPVIT TSAIKNKGLD EVIKAALRSP EVQPLDYDHR LEGALSEISK
     VTGFTNRFEQ IKVFEGDQLL LTKLSAEQLD EVEEIVSITE KLMTDDRESI IVNERYDLIG
     HFVQLSVSQT ETGKVNLTDR IDQIITHKWL GLPIFVFIMW LVYFISIQTV GTAATDWLND
     VFFGQWLPDL IANGMNALAV TPWVQDLVLN GVVAGIGAIL GFVPQIFVLF LLLGILEDSG
     YMARVAFVMD RIFRRFGLSG KSFIPMLIAS GCGVAGIMAT RTIEQERDRK ITIMVTTFMP
     CSAKLPIIAL VSGAFFPHAS WVAPSAYFLG MSMIILSGII LKKTRMFSGD TSAFIMELPT
     YHLPYALTVL KYAFDRAFSF VKRAGTIIFA MNVLIWFTSN YNWTLAHVDA GQSILADVGK
     VVAVVFAPLG FGEWRATVAT ITGLIAKETI VGTMGVLFAH NSGDSHQLWS AVQATYIPLS
     AYSLLVFNLL CAPCVAAIST IYKEMGDVRW TLRAVGFQTL VAYSMSFIIY QLGSFFSSQN
     FDVLSLVALL VLLVGLYFIF RKGKDVSYEL S
//
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