ID   T0SEJ9_LACLC            Unreviewed;       670 AA.
AC   T0SEJ9;
DT   16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT   16-OCT-2013, sequence version 1.
DT   27-MAR-2024, entry version 42.
DE   RecName: Full=exoribonuclease II {ECO:0000256|ARBA:ARBA00012163};
DE            EC=3.1.13.1 {ECO:0000256|ARBA:ARBA00012163};
DE   Flags: Fragment;
GN   ORFNames=LLT6_09170 {ECO:0000313|EMBL:EQC57417.1};
OS   Lactococcus cremoris subsp. cremoris TIFN6.
OC   Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC   Lactococcus; Lactococcus cremoris subsp. cremoris.
OX   NCBI_TaxID=1234876 {ECO:0000313|EMBL:EQC57417.1, ECO:0000313|Proteomes:UP000015854};
RN   [1] {ECO:0000313|EMBL:EQC57417.1, ECO:0000313|Proteomes:UP000015854}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TIFN6 {ECO:0000313|EMBL:EQC57417.1,
RC   ECO:0000313|Proteomes:UP000015854};
RX   PubMed=23823494; DOI=10.1038/ismej.2013.108;
RA   Erkus O., de Jager V.C., Spus M., van Alen-Boerrigter I.J.,
RA   van Rijswijck I.M., Hazelwood L., Janssen P.W., van Hijum S.A.,
RA   Kleerebezem M., Smid E.J.;
RT   "Multifactorial diversity sustains microbial community stability.";
RL   ISME J. 7:2126-2136(2013).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Exonucleolytic cleavage in the 3'- to 5'-direction to yield
CC         nucleoside 5'-phosphates.; EC=3.1.13.1;
CC         Evidence={ECO:0000256|ARBA:ARBA00001849};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EQC57417.1}.
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DR   EMBL; ATBB01000140; EQC57417.1; -; Genomic_DNA.
DR   AlphaFoldDB; T0SEJ9; -.
DR   Proteomes; UP000015854; Unassembled WGS sequence.
DR   GO; GO:0008859; F:exoribonuclease II activity; IEA:UniProtKB-EC.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0016070; P:RNA metabolic process; IEA:InterPro.
DR   CDD; cd04471; S1_RNase_R; 1.
DR   Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 2.
DR   HAMAP; MF_01895; RNase_R; 1.
DR   InterPro; IPR011129; CSD.
DR   InterPro; IPR040476; CSD2.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR013223; RNase_B_OB_dom.
DR   InterPro; IPR001900; RNase_II/R.
DR   InterPro; IPR022966; RNase_II/R_CS.
DR   InterPro; IPR004476; RNase_II/RNase_R.
DR   InterPro; IPR011805; RNase_R.
DR   InterPro; IPR003029; S1_domain.
DR   NCBIfam; TIGR00358; 3_prime_RNase; 1.
DR   NCBIfam; TIGR02063; RNase_R; 1.
DR   PANTHER; PTHR23355:SF9; DIS3-LIKE EXONUCLEASE 2; 1.
DR   PANTHER; PTHR23355; RIBONUCLEASE; 1.
DR   Pfam; PF17876; CSD2; 1.
DR   Pfam; PF08206; OB_RNB; 1.
DR   Pfam; PF00773; RNB; 1.
DR   Pfam; PF00575; S1; 1.
DR   SMART; SM00357; CSP; 1.
DR   SMART; SM00955; RNB; 1.
DR   SMART; SM00316; S1; 1.
DR   SUPFAM; SSF50249; Nucleic acid-binding proteins; 3.
DR   PROSITE; PS01175; RIBONUCLEASE_II; 1.
DR   PROSITE; PS50126; S1; 1.
PE   3: Inferred from homology;
KW   Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW   Reference proteome {ECO:0000313|Proteomes:UP000015854}.
FT   DOMAIN          579..662
FT                   /note="S1 motif"
FT                   /evidence="ECO:0000259|PROSITE:PS50126"
FT   NON_TER         670
FT                   /evidence="ECO:0000313|EMBL:EQC57417.1"
SQ   SEQUENCE   670 AA;  75758 MW;  717F71C2D21518B1 CRC64;
     MVQLSELASA LKQTESKGVF SKHPKGFGFV HPEGETDKTN DIYIGQNETK FAMDGDKVTV
     KVLYPKTERR GASGQIIKIN ERAVVDTVGT YRSLSNRQAK ALGYKGRIEL FNDRISDTLY
     IKQPLTGVQE EDVVSIKVTQ YPTDTKAFEG KITQIIGHKG EVGLDILEVL YAMKIPQEFS
     AETLAEAESF SEELTQEDLQ GREDYRNEIT YTIDGEDSKD LDDAIHVKKL SNGHFELGVH
     IADVSHYVTE GSSLNEEAYA RATSVYVTDR VVPMLPVRLS NNLCSLNEAQ ERLTMSCLME
     IDDKGKIVTY KISPSVIKTT YRMTYSNVNK MIHQGQEGHR EALEKFSKIA DSIEVAVELH
     EILETMRKDR GMIEFDESEA KIILDDEGHP IEIVKRDRDT AERMIESFML MANETVALDF
     QKKKLPSLYR VHETPKEKAF AKLMEAAAEA GFSLSSDSHQ AINFFADEIK GTSFEKALTY
     QLRHTMSTAV YSEKNTKHFG LAATNYTHFT SPIRRYPDLI IHRLLHLYPS DHSNRTKDEW
     KERLPEIASH SSDMEHRAVV TERIIDAMKK AEYMLERIGE VYTGTITGVQ KFGIFVALDN
     TVEGLVRVPN LHTGTTEELD FDEEMSIIKG KKSETIYQVG KEIKICVIAA NKRKGTVDFE
     QIAPEKTSNL
//