ID   T0TIA1_9STRE            Unreviewed;       402 AA.
AC   T0TIA1;
DT   16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT   16-OCT-2013, sequence version 1.
DT   24-JAN-2024, entry version 32.
DE   SubName: Full=Alcohol dehydrogenase Acetaldehyde dehydrogenase {ECO:0000313|EMBL:EQC70766.1};
DE            EC=1.1.1.1 {ECO:0000313|EMBL:EQC70766.1};
DE            EC=1.2.1.10 {ECO:0000313|EMBL:EQC70766.1};
GN   ORFNames=HSISB1_262 {ECO:0000313|EMBL:EQC70766.1};
OS   Streptococcus sp. HSISB1.
OC   Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=1316409 {ECO:0000313|EMBL:EQC70766.1};
RN   [1] {ECO:0000313|EMBL:EQC70766.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HSISB1 {ECO:0000313|EMBL:EQC70766.1};
RA   Van den Bogert B., Boekhorst J., Herrmann R., Smid E.J., Zoetendal E.G.,
RA   Kleerebezem M.;
RT   "Comparative Genomics Analysis of Streptococcus Isolates from the Human
RT   Small Intestine Reveals their Adaptation to a Highly Dynamic Ecosystem.";
RL   PLoS ONE 8:E83418-E83418(2013).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EQC70766.1}.
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DR   EMBL; ASKA01000005; EQC70766.1; -; Genomic_DNA.
DR   AlphaFoldDB; T0TIA1; -.
DR   PATRIC; fig|1316409.3.peg.2107; -.
DR   HOGENOM; CLU_007207_0_0_9; -.
DR   Proteomes; UP000015934; Chromosome.
DR   GO; GO:0008774; F:acetaldehyde dehydrogenase (acetylating) activity; IEA:UniProtKB-EC.
DR   GO; GO:0004022; F:alcohol dehydrogenase (NAD+) activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   CDD; cd08178; AAD_C; 1.
DR   Gene3D; 3.40.50.1970; -; 1.
DR   Gene3D; 1.20.1090.10; Dehydroquinate synthase-like - alpha domain; 1.
DR   InterPro; IPR034789; AAD_C.
DR   InterPro; IPR001670; ADH_Fe/GldA.
DR   InterPro; IPR018211; ADH_Fe_CS.
DR   InterPro; IPR039697; Alcohol_dehydrogenase_Fe.
DR   PANTHER; PTHR11496; ALCOHOL DEHYDROGENASE; 1.
DR   PANTHER; PTHR11496:SF83; HYDROXYACID-OXOACID TRANSHYDROGENASE, MITOCHONDRIAL; 1.
DR   Pfam; PF00465; Fe-ADH; 1.
DR   SUPFAM; SSF56796; Dehydroquinate synthase-like; 1.
DR   PROSITE; PS00913; ADH_IRON_1; 1.
PE   4: Predicted;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW   ECO:0000313|EMBL:EQC70766.1}.
FT   DOMAIN          2..391
FT                   /note="Alcohol dehydrogenase iron-type/glycerol
FT                   dehydrogenase GldA"
FT                   /evidence="ECO:0000259|Pfam:PF00465"
SQ   SEQUENCE   402 AA;  44572 MW;  995900847DD947F0 CRC64;
     MQRALIVADP GMVQFGFVDT VLAQLALRDE KVATSIYGTI KPDPTLGQTI EIAKQMRDFK
     PDTVIAVGGG SALDAAKIAR YIYEYSLDQE ADFLDSYENV SELFLRLQQK FIDIRKRIVK
     FKHQTATRLF CIPTTSGTGS EVTPYAVITD DHTHVKYPLT DYELTPQVAI VDPEFVMTVP
     KRTVALSGLD TLSHALEAYV SVMASDLTRP WSLEAIKLVI ENLEDSYNYD PKHPTLRGEQ
     ARENMHYAAT LAGMAFSNAF LGINHSIAHK TGGEFGLPHG LAISIAMQHV IRYNGVAGNV
     KRSVFPRYEE YRAQRDYADI ARSLGLKGKD DAALVEALCE RIDALMKAVD VDPRLSANGV
     TKEAFDAAVD KLASLAYDDQ CTPANPRQPY ISELKQLLID MF
//