ID T0TMB3_9STRE Unreviewed; 581 AA.
AC T0TMB3;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE SubName: Full=Lipid A export ATP-binding/permease protein MsbA {ECO:0000313|EMBL:EQC72096.1};
GN ORFNames=HSISS2_1726 {ECO:0000313|EMBL:EQC72096.1};
OS Streptococcus sp. HSISS2.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=1316411 {ECO:0000313|EMBL:EQC72096.1};
RN [1] {ECO:0000313|EMBL:EQC72096.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HSISS2 {ECO:0000313|EMBL:EQC72096.1};
RA Van den Bogert B., Boekhorst J., Herrmann R., Smid E.J., Zoetendal E.G.,
RA Kleerebezem M.;
RT "Comparative Genomics Analysis of Streptococcus Isolates from the Human
RT Small Intestine Reveals their Adaptation to a Highly Dynamic Ecosystem.";
RL PLoS ONE 8:E83418-E83418(2013).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EQC72096.1}.
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DR EMBL; ASKC01000143; EQC72096.1; -; Genomic_DNA.
DR AlphaFoldDB; T0TMB3; -.
DR PATRIC; fig|1316411.3.peg.527; -.
DR HOGENOM; CLU_000604_84_4_9; -.
DR Proteomes; UP000015938; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd18548; ABC_6TM_Tm287_like; 1.
DR Gene3D; 1.20.1560.10; ABC transporter type 1, transmembrane domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR011527; ABC1_TM_dom.
DR InterPro; IPR036640; ABC1_TM_sf.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR039421; Type_1_exporter.
DR PANTHER; PTHR24221:SF276; ABC TRANSPORTER, ATP-BINDING_PERMEASE PROTEIN; 1.
DR PANTHER; PTHR24221; ATP-BINDING CASSETTE SUB-FAMILY B; 1.
DR Pfam; PF00664; ABC_membrane; 1.
DR Pfam; PF00005; ABC_tran; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF90123; ABC transporter transmembrane region; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50929; ABC_TM1F; 1.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000313|EMBL:EQC72096.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 21..41
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 53..72
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 134..152
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 158..179
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 233..257
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 277..297
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 17..297
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000259|PROSITE:PS50929"
FT DOMAIN 332..570
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
SQ SEQUENCE 581 AA; 64728 MW; B78EF3BCBCB6CC3C CRC64;
MFQTLIAQIK EYKKPSILAS LFMTLEVMFE ISIPFVMANL LDKGVQQSNM SNIWFYGGLM
LVCAFLSLFC GMQSARYAAF ASAGFAKNLR QAIFKKVQSF SFENIDKFSA GGLVTRMMTD
VTNVQNSYQM IIRICVRAPL NLIFAITASF LINGQMAWIF VGVTLFLGVI LALITKIVYP
LFTQVFEAYD NLNNSIKENI TNMRVVKSYV KEQEETDKFK RASRRIYQMF MRAIRVVVMS
NPAMMLSMYA SFLMISWFGA HLIVVGNLST GELTSMFSYT MTILISLMMF MMIFVMLSIS
MASVERINDV LSTEATILSP ENGLTEVADG SISFDHVDFS YTDENGDKTH VLKDITLDIK
SGEVIGILGG TGSGKSSLVQ LIPRLYDVEA GQVKVAGHNV KDYDLDSLRK QVAMVLQTNV
LFSGTIKENM RWGNKQATDE EIIQACKIAQ ADEFIQEFKD GYDTKIERGG ANVSGGQRQR
LCIARALLMN PKILILDDST SAVDTKTDSL IRQGFASSLK DTTKIIIGQR ISSIQDADRI
IVMNDGRIDA IGSHDDLVAN NAIYRDVYKM QTQGKGVADA E
//
