ID T0V2L2_9STRE Unreviewed; 252 AA.
AC T0V2L2;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 24-JAN-2024, entry version 30.
DE RecName: Full=UDP-N-acetylglucosamine kinase {ECO:0000256|ARBA:ARBA00011963};
DE EC=2.7.1.176 {ECO:0000256|ARBA:ARBA00011963};
DE AltName: Full=UDP-N-acetylglucosamine kinase {ECO:0000256|ARBA:ARBA00032897};
GN ORFNames=HSISM1_2168 {ECO:0000313|EMBL:EQC76094.1};
OS Streptococcus sp. HSISM1.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=1316408 {ECO:0000313|EMBL:EQC76094.1};
RN [1] {ECO:0000313|EMBL:EQC76094.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HSISM1 {ECO:0000313|EMBL:EQC76094.1};
RA Van den Bogert B., Boekhorst J., Herrmann R., Smid E.J., Zoetendal E.G.,
RA Kleerebezem M.;
RT "Comparative Genomics Analysis of Streptococcus Isolates from the Human
RT Small Intestine Reveals their Adaptation to a Highly Dynamic Ecosystem.";
RL PLoS ONE 8:E83418-E83418(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + UDP-N-acetyl-alpha-D-glucosamine = ADP + H(+) + UDP-N-
CC acetyl-alpha-D-glucosamine 3'-phosphate; Xref=Rhea:RHEA:32671,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:57705,
CC ChEBI:CHEBI:64353, ChEBI:CHEBI:456216; EC=2.7.1.176;
CC Evidence={ECO:0000256|ARBA:ARBA00000912};
CC -!- SIMILARITY: Belongs to the zeta toxin family.
CC {ECO:0000256|ARBA:ARBA00009104}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EQC76094.1}.
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DR EMBL; ASKI01000076; EQC76094.1; -; Genomic_DNA.
DR AlphaFoldDB; T0V2L2; -.
DR PATRIC; fig|1316408.3.peg.1744; -.
DR eggNOG; COG4185; Bacteria.
DR HOGENOM; CLU_064262_2_0_9; -.
DR Proteomes; UP000015933; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016301; F:kinase activity; IEA:InterPro.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR048180; PezT.
DR InterPro; IPR010488; Zeta_toxin_domain.
DR NCBIfam; NF041574; antitoxPezT_Strep; 1.
DR Pfam; PF06414; Zeta_toxin; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Toxin-antitoxin system {ECO:0000256|ARBA:ARBA00022649}.
FT DOMAIN 26..215
FT /note="Zeta toxin"
FT /evidence="ECO:0000259|Pfam:PF06414"
SQ SEQUENCE 252 AA; 28846 MW; D9EE1DA8123AE7CC CRC64;
MKLEEFSQDD FERASRRLVR SLTRGKTTSS QPKAILLGGQ SGAGKTTIHR IKQREFQGNI
IIIDGDSYRS FHPNYLGLQK KYGKDSVDYT KVFAGKMVEY LVDELSKQGY HLLIEGTLRT
TEVPRKTAQL LAIRGYQVSL ALIATKPELS YLSTLIRYEE LYAINPSQAR ATPKAHHDGI
VEHLVDNLRE LENDKIFNQI QIYQRDQSCV YDSEVDQISA AEVLQECLFG KWNKVEKEML
KMGKERLKEL GE
//
