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Database: UniProt
Entry: T0VGP9_9ENTE
LinkDB: T0VGP9_9ENTE
Original site: T0VGP9_9ENTE 
ID   T0VGP9_9ENTE            Unreviewed;       381 AA.
AC   T0VGP9;
DT   16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT   16-OCT-2013, sequence version 1.
DT   16-JAN-2019, entry version 30.
DE   RecName: Full=Phosphoribosylamine--glycine ligase {ECO:0000256|HAMAP-Rule:MF_00138};
DE            EC=6.3.4.13 {ECO:0000256|HAMAP-Rule:MF_00138};
DE   AltName: Full=GARS {ECO:0000256|HAMAP-Rule:MF_00138};
DE   AltName: Full=Glycinamide ribonucleotide synthetase {ECO:0000256|HAMAP-Rule:MF_00138};
DE   AltName: Full=Phosphoribosylglycinamide synthetase {ECO:0000256|HAMAP-Rule:MF_00138};
GN   Name=purD {ECO:0000256|HAMAP-Rule:MF_00138};
GN   ORFNames=HSIEG1_41 {ECO:0000313|EMBL:EQC78703.1};
OS   Enterococcus sp. HSIEG1.
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Enterococcaceae;
OC   Enterococcus.
OX   NCBI_TaxID=1316414 {ECO:0000313|EMBL:EQC78703.1, ECO:0000313|Proteomes:UP000015939};
RN   [1] {ECO:0000313|EMBL:EQC78703.1, ECO:0000313|Proteomes:UP000015939}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HSIEG1 {ECO:0000313|EMBL:EQC78703.1};
RX   PubMed=24336366;
RA   van den Bogert B., Boekhorst J., Smid E.J., Zoetendal E.G.,
RA   Kleerebezem M.;
RT   "Draft Genome Sequence of Enterococcus sp. Strain HSIEG1, Isolated
RT   from the Human Small Intestine.";
RL   Genome Announc. 1:e01013-13(2013).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=5-phospho-D-ribosylamine + ATP + glycine = ADP + H(+) +
CC         N(1)-(5-phospho-D-ribosyl)glycinamide + phosphate;
CC         Xref=Rhea:RHEA:17453, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:57305, ChEBI:CHEBI:58089,
CC         ChEBI:CHEBI:58457, ChEBI:CHEBI:456216; EC=6.3.4.13;
CC         Evidence={ECO:0000256|HAMAP-Rule:MF_00138};
CC   -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway;
CC       N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-
CC       ribose 1-diphosphate: step 2/2. {ECO:0000256|HAMAP-Rule:MF_00138}.
CC   -!- SIMILARITY: Belongs to the GARS family. {ECO:0000256|HAMAP-
CC       Rule:MF_00138}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:EQC78703.1}.
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DR   EMBL; ASKG01000130; EQC78703.1; -; Genomic_DNA.
DR   EnsemblBacteria; EQC78703; EQC78703; HSIEG1_41.
DR   PATRIC; fig|1316414.3.peg.1122; -.
DR   UniPathway; UPA00074; UER00125.
DR   Proteomes; UP000015939; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   GO; GO:0004637; F:phosphoribosylamine-glycine ligase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006189; P:'de novo' IMP biosynthetic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0009113; P:purine nucleobase biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.30.1490.20; -; 1.
DR   Gene3D; 3.90.600.10; -; 1.
DR   HAMAP; MF_00138; GARS; 1.
DR   InterPro; IPR011761; ATP-grasp.
DR   InterPro; IPR013815; ATP_grasp_subdomain_1.
DR   InterPro; IPR016185; PreATP-grasp_dom_sf.
DR   InterPro; IPR020561; PRibGlycinamid_synth_ATP-grasp.
DR   InterPro; IPR000115; PRibGlycinamide_synth.
DR   InterPro; IPR020560; PRibGlycinamide_synth_C-dom.
DR   InterPro; IPR037123; PRibGlycinamide_synth_C_sf.
DR   InterPro; IPR020559; PRibGlycinamide_synth_CS.
DR   InterPro; IPR020562; PRibGlycinamide_synth_N.
DR   InterPro; IPR011054; Rudment_hybrid_motif.
DR   Pfam; PF01071; GARS_A; 1.
DR   Pfam; PF02843; GARS_C; 1.
DR   Pfam; PF02844; GARS_N; 1.
DR   SMART; SM01210; GARS_C; 1.
DR   SUPFAM; SSF51246; SSF51246; 1.
DR   SUPFAM; SSF52440; SSF52440; 1.
DR   TIGRFAMs; TIGR00877; purD; 1.
DR   PROSITE; PS50975; ATP_GRASP; 1.
DR   PROSITE; PS00184; GARS; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|PROSITE-ProRule:PRU00409};
KW   Complete proteome {ECO:0000313|Proteomes:UP000015939};
KW   Ligase {ECO:0000256|HAMAP-Rule:MF_00138, ECO:0000313|EMBL:EQC78703.1};
KW   Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU00409};
KW   Purine biosynthesis {ECO:0000256|HAMAP-Rule:MF_00138};
KW   Reference proteome {ECO:0000313|Proteomes:UP000015939}.
FT   DOMAIN       72    278       ATP-grasp. {ECO:0000259|PROSITE:PS50975}.
SQ   SEQUENCE   381 AA;  40851 MW;  33E3F8DDB30925AF CRC64;
     MVSDGIQVVA IPETDHQSLI AFAKEMAIDW TFVGPEVPLL NGIVDDFQAA GLNIFGPNKA
     AAMIEGSKEF AKELMAKYQI PTAEYQSFVD SEKAKAYIQE KGAPIVIKAD GLAAGKGVVV
     AATVDQALAA VEEMLEEQKF GQSGAKVVIE DFLEGEEFSL LAFVHEEQVY PMVIAQDHKR
     AFDGDEGPNT GGMGAYSPVP QIPQSMIDQA IETVLIPAAT GMIDQGTPFT GILYAGLIAT
     VEGPKVIEFN ARFGDPETQV VLSRLTSGLA QIIDALLNGR QPEITWDQQF SVGVVVAAEG
     YPETYQQGMI IPQKAAEDVQ LFYAGVAERA GELVAAGGRV FLAEGQGASL EEAQKKVYQA
     LAKMPLNKMF YRKDIGAKAL K
//
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