ID T0Z419_9BACT Unreviewed; 266 AA.
AC T0Z419;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=5-methyltetrahydrofolate-homocysteine methyltransferase {ECO:0000313|EMBL:EQD24355.1};
DE Flags: Fragment;
GN ORFNames=D084_Lepto4C00468G0001 {ECO:0000313|EMBL:EQD24355.1};
OS Leptospirillum sp. Group IV 'UBA BS'.
OC Bacteria; Nitrospirota; Nitrospiria; Nitrospirales; Nitrospiraceae;
OC Leptospirillum.
OX NCBI_TaxID=1260983 {ECO:0000313|EMBL:EQD24355.1, ECO:0000313|Proteomes:UP000017751};
RN [1] {ECO:0000313|EMBL:EQD24355.1, ECO:0000313|Proteomes:UP000017751}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23645189; DOI=10.1128/AEM.00202-13;
RA Goltsman D.S., Dasari M., Thomas B.C., Shah M.B., VerBerkmoes N.C.,
RA Hettich R.L., Banfield J.F.;
RT "New group in the Leptospirillum clade: cultivation-independent community
RT genomics, proteomics, and transcriptomics of the new species
RT "Leptospirillum group IV UBA BS".";
RL Appl. Environ. Microbiol. 79:5384-5393(2013).
CC -!- SIMILARITY: Belongs to the vitamin-B12 dependent methionine synthase
CC family. {ECO:0000256|ARBA:ARBA00010398}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EQD24355.1}.
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DR EMBL; AURA01000468; EQD24355.1; -; Genomic_DNA.
DR AlphaFoldDB; T0Z419; -.
DR HOGENOM; CLU_070996_0_0_0; -.
DR Proteomes; UP000017751; Unassembled WGS sequence.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0042558; P:pteridine-containing compound metabolic process; IEA:InterPro.
DR Gene3D; 3.20.20.20; Dihydropteroate synthase-like; 1.
DR InterPro; IPR011005; Dihydropteroate_synth-like_sf.
DR InterPro; IPR000489; Pterin-binding_dom.
DR PANTHER; PTHR45833; METHIONINE SYNTHASE; 1.
DR PANTHER; PTHR45833:SF1; METHIONINE SYNTHASE; 1.
DR Pfam; PF00809; Pterin_bind; 1.
DR SUPFAM; SSF51717; Dihydropteroate synthetase-like; 1.
DR PROSITE; PS50972; PTERIN_BINDING; 1.
PE 3: Inferred from homology;
KW Cobalt {ECO:0000256|ARBA:ARBA00023285};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:EQD24355.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000017751};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:EQD24355.1}.
FT DOMAIN 1..216
FT /note="Pterin-binding"
FT /evidence="ECO:0000259|PROSITE:PS50972"
FT REGION 236..266
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 266
FT /evidence="ECO:0000313|EMBL:EQD24355.1"
SQ SEQUENCE 266 AA; 28476 MW; C2B8BAA28A2C055B CRC64;
MAEARKEAAA GAHALDVNVG VPLVDEARMM EKAVTAIGNV VSLPLVIDSS FASALEAGLR
LYPGRALVNS VNAEEERIEE VLPLIRRYGA AVIGLLSGED IPEKAADRIR NAEKILRAAE
RFGLRPEDIV FDTLALTVSA VQEASRQTLE TIRILKTEWN ARTIVGLSNV SFGLPVRKTV
HDTFLAMAIG SGLDGAICDP YDPLLHQTVA AASLFSGRDP ECRVFMEKAA TWTPLVPSNT
AGTQTGMPAG GITPDHPLST PEKIER
//
