ID T106C_HUMAN Reviewed; 250 AA.
AC Q9BVX2; B2R998; B7Z5M4; Q3B761;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 27-MAR-2024, entry version 153.
DE RecName: Full=Transmembrane protein 106C;
DE AltName: Full=Endoplasmic reticulum membrane protein overexpressed in cancer;
GN Name=TMEM106C; Synonyms=EMOC;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND SUBCELLULAR LOCATION.
RA Jin W., Sun Q., Rong R., He Q., Sheikh M.S., Huang Y.;
RT "EMOC, a novel stress-regulated gene, encodes an endoplasmic reticulum
RT transmembrane protein and is overexpressed in multiple human
RT malignancies.";
RL Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), AND VARIANT
RP PHE-103.
RC TISSUE=Cervix, and Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP INTERACTION WITH TMEM106B.
RX PubMed=25066864; DOI=10.1016/j.mcn.2014.07.006;
RA Stagi M., Klein Z.A., Gould T.J., Bewersdorf J., Strittmatter S.M.;
RT "Lysosome size, motility and stress response regulated by fronto-temporal
RT dementia modifier TMEM106B.";
RL Mol. Cell. Neurosci. 61:226-240(2014).
RN [6]
RP MYRISTOYLATION AT GLY-2, CLEAVAGE OF INITIATOR METHIONINE, AND
RP IDENTIFICATION BY MASS SPECTROMETRY.
RX PubMed=25807930; DOI=10.1002/anie.201500342;
RA Broncel M., Serwa R.A., Ciepla P., Krause E., Dallman M.J., Magee A.I.,
RA Tate E.W.;
RT "Multifunctional reagents for quantitative proteome-wide analysis of
RT protein modification in human cells and dynamic profiling of protein
RT lipidation during vertebrate development.";
RL Angew. Chem. Int. Ed. 54:5948-5951(2015).
CC -!- SUBUNIT: Interacts with TMEM106B. {ECO:0000269|PubMed:25066864}.
CC -!- INTERACTION:
CC Q9BVX2; Q08AM2: ADAM33; NbExp=3; IntAct=EBI-2821497, EBI-10225815;
CC Q9BVX2; Q9NVV5-2: AIG1; NbExp=3; IntAct=EBI-2821497, EBI-11957045;
CC Q9BVX2; Q12983: BNIP3; NbExp=3; IntAct=EBI-2821497, EBI-749464;
CC Q9BVX2; Q8N6F1-2: CLDN19; NbExp=3; IntAct=EBI-2821497, EBI-12256978;
CC Q9BVX2; Q96FZ5: CMTM7; NbExp=3; IntAct=EBI-2821497, EBI-2807956;
CC Q9BVX2; Q4LDR2: CTXN3; NbExp=3; IntAct=EBI-2821497, EBI-12019274;
CC Q9BVX2; Q07325: CXCL9; NbExp=3; IntAct=EBI-2821497, EBI-3911467;
CC Q9BVX2; P56851: EDDM3B; NbExp=3; IntAct=EBI-2821497, EBI-10215665;
CC Q9BVX2; Q96IV6: FAXDC2; NbExp=3; IntAct=EBI-2821497, EBI-12142299;
CC Q9BVX2; O14653: GOSR2; NbExp=3; IntAct=EBI-2821497, EBI-4401517;
CC Q9BVX2; B0YJ81: HACD1; NbExp=4; IntAct=EBI-2821497, EBI-12051643;
CC Q9BVX2; P24593: IGFBP5; NbExp=3; IntAct=EBI-2821497, EBI-720480;
CC Q9BVX2; Q8N5M9: JAGN1; NbExp=3; IntAct=EBI-2821497, EBI-10266796;
CC Q9BVX2; Q15323: KRT31; NbExp=6; IntAct=EBI-2821497, EBI-948001;
CC Q9BVX2; P21145: MAL; NbExp=3; IntAct=EBI-2821497, EBI-3932027;
CC Q9BVX2; Q9P0N8: MARCHF2; NbExp=3; IntAct=EBI-2821497, EBI-10317612;
CC Q9BVX2; Q96S97: MYADM; NbExp=3; IntAct=EBI-2821497, EBI-13301517;
CC Q9BVX2; Q16617: NKG7; NbExp=3; IntAct=EBI-2821497, EBI-3919611;
CC Q9BVX2; Q8N912: NRAC; NbExp=3; IntAct=EBI-2821497, EBI-12051377;
CC Q9BVX2; Q8IZ57: NRSN1; NbExp=3; IntAct=EBI-2821497, EBI-10264528;
CC Q9BVX2; P0DJD7: PGA4; NbExp=3; IntAct=EBI-2821497, EBI-12957629;
CC Q9BVX2; P26678: PLN; NbExp=3; IntAct=EBI-2821497, EBI-692836;
CC Q9BVX2; P60201-2: PLP1; NbExp=3; IntAct=EBI-2821497, EBI-12188331;
CC Q9BVX2; Q8IY26: PLPP6; NbExp=3; IntAct=EBI-2821497, EBI-11721828;
CC Q9BVX2; P53801: PTTG1IP; NbExp=3; IntAct=EBI-2821497, EBI-3906138;
CC Q9BVX2; Q9NS64: RPRM; NbExp=3; IntAct=EBI-2821497, EBI-1052363;
CC Q9BVX2; Q96IW7: SEC22A; NbExp=3; IntAct=EBI-2821497, EBI-8652744;
CC Q9BVX2; Q8N6R1: SERP2; NbExp=3; IntAct=EBI-2821497, EBI-749270;
CC Q9BVX2; P11686: SFTPC; NbExp=3; IntAct=EBI-2821497, EBI-10197617;
CC Q9BVX2; Q0VAQ4: SMAGP; NbExp=3; IntAct=EBI-2821497, EBI-10226799;
CC Q9BVX2; Q96A25: TMEM106A; NbExp=3; IntAct=EBI-2821497, EBI-3915978;
CC Q9BVX2; Q9NUM4: TMEM106B; NbExp=3; IntAct=EBI-2821497, EBI-10490807;
CC Q9BVX2; P17152: TMEM11; NbExp=3; IntAct=EBI-2821497, EBI-723946;
CC Q9BVX2; A2RU14: TMEM218; NbExp=3; IntAct=EBI-2821497, EBI-10173151;
CC Q9BVX2; Q53FP2: TMEM35A; NbExp=3; IntAct=EBI-2821497, EBI-11722971;
CC Q9BVX2; Q5BJF2: TMEM97; NbExp=3; IntAct=EBI-2821497, EBI-12111910;
CC Q9BVX2; Q86UF1: TSPAN33; NbExp=4; IntAct=EBI-2821497, EBI-12045841;
CC Q9BVX2; O00526: UPK2; NbExp=3; IntAct=EBI-2821497, EBI-10179682;
CC Q9BVX2; O95183: VAMP5; NbExp=3; IntAct=EBI-2821497, EBI-10191195;
CC Q9BVX2; Q96EC8: YIPF6; NbExp=3; IntAct=EBI-2821497, EBI-751210;
CC Q9BVX2; O95159: ZFPL1; NbExp=3; IntAct=EBI-2821497, EBI-718439;
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000269|Ref.1}; Multi-pass membrane protein {ECO:0000269|Ref.1}.
CC Membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9BVX2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9BVX2-2; Sequence=VSP_019483;
CC -!- SIMILARITY: Belongs to the TMEM106 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; DQ020163; AAY84826.1; -; mRNA.
DR EMBL; AK299154; BAH12960.1; -; mRNA.
DR EMBL; AK313698; BAG36445.1; -; mRNA.
DR EMBL; CH471111; EAW57965.1; -; Genomic_DNA.
DR EMBL; BC000854; AAH00854.1; -; mRNA.
DR EMBL; BC107792; AAI07793.1; -; mRNA.
DR CCDS; CCDS44867.1; -. [Q9BVX2-2]
DR CCDS; CCDS8758.1; -. [Q9BVX2-1]
DR RefSeq; NP_001137313.1; NM_001143841.1. [Q9BVX2-2]
DR RefSeq; NP_001137314.1; NM_001143842.1. [Q9BVX2-1]
DR RefSeq; NP_001137315.1; NM_001143843.1. [Q9BVX2-2]
DR RefSeq; NP_076961.1; NM_024056.3. [Q9BVX2-1]
DR AlphaFoldDB; Q9BVX2; -.
DR BioGRID; 122490; 88.
DR IntAct; Q9BVX2; 50.
DR MINT; Q9BVX2; -.
DR STRING; 9606.ENSP00000400471; -.
DR TCDB; 9.B.23.1.4; the tmem106 (tmem106) family.
DR GlyCosmos; Q9BVX2; 2 sites, No reported glycans.
DR GlyGen; Q9BVX2; 2 sites.
DR iPTMnet; Q9BVX2; -.
DR PhosphoSitePlus; Q9BVX2; -.
DR SwissPalm; Q9BVX2; -.
DR BioMuta; TMEM106C; -.
DR DMDM; 74733372; -.
DR jPOST; Q9BVX2; -.
DR MassIVE; Q9BVX2; -.
DR MaxQB; Q9BVX2; -.
DR PaxDb; 9606-ENSP00000400471; -.
DR PeptideAtlas; Q9BVX2; -.
DR ProteomicsDB; 79242; -. [Q9BVX2-1]
DR ProteomicsDB; 79243; -. [Q9BVX2-2]
DR Pumba; Q9BVX2; -.
DR Antibodypedia; 25478; 37 antibodies from 18 providers.
DR DNASU; 79022; -.
DR Ensembl; ENST00000256686.10; ENSP00000256686.6; ENSG00000134291.12. [Q9BVX2-2]
DR Ensembl; ENST00000429772.7; ENSP00000400471.2; ENSG00000134291.12. [Q9BVX2-1]
DR Ensembl; ENST00000449758.6; ENSP00000402705.2; ENSG00000134291.12. [Q9BVX2-2]
DR Ensembl; ENST00000550552.5; ENSP00000449737.1; ENSG00000134291.12. [Q9BVX2-2]
DR Ensembl; ENST00000552561.5; ENSP00000446657.1; ENSG00000134291.12. [Q9BVX2-1]
DR GeneID; 79022; -.
DR KEGG; hsa:79022; -.
DR MANE-Select; ENST00000429772.7; ENSP00000400471.2; NM_001143842.2; NP_001137314.1.
DR UCSC; uc001rqo.4; human. [Q9BVX2-1]
DR AGR; HGNC:28775; -.
DR CTD; 79022; -.
DR GeneCards; TMEM106C; -.
DR HGNC; HGNC:28775; TMEM106C.
DR HPA; ENSG00000134291; Low tissue specificity.
DR neXtProt; NX_Q9BVX2; -.
DR OpenTargets; ENSG00000134291; -.
DR PharmGKB; PA142670757; -.
DR VEuPathDB; HostDB:ENSG00000134291; -.
DR eggNOG; ENOG502QQ43; Eukaryota.
DR GeneTree; ENSGT00940000161281; -.
DR HOGENOM; CLU_089337_0_0_1; -.
DR InParanoid; Q9BVX2; -.
DR OMA; PYVYAFC; -.
DR OrthoDB; 5353335at2759; -.
DR PhylomeDB; Q9BVX2; -.
DR TreeFam; TF328907; -.
DR PathwayCommons; Q9BVX2; -.
DR SignaLink; Q9BVX2; -.
DR BioGRID-ORCS; 79022; 11 hits in 1161 CRISPR screens.
DR ChiTaRS; TMEM106C; human.
DR GenomeRNAi; 79022; -.
DR Pharos; Q9BVX2; Tdark.
DR PRO; PR:Q9BVX2; -.
DR Proteomes; UP000005640; Chromosome 12.
DR RNAct; Q9BVX2; Protein.
DR Bgee; ENSG00000134291; Expressed in rectum and 190 other cell types or tissues.
DR ExpressionAtlas; Q9BVX2; baseline and differential.
DR Genevisible; Q9BVX2; HS.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR009790; TMEM106.
DR InterPro; IPR048509; TMEM106_C.
DR InterPro; IPR048511; TMEM106_N.
DR PANTHER; PTHR28556; TRANSMEMBRANE PROTEIN 106B; 1.
DR PANTHER; PTHR28556:SF5; TRANSMEMBRANE PROTEIN 106C; 1.
DR Pfam; PF07092; TMEM106; 1.
DR Pfam; PF21002; TMEM106_N; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Endoplasmic reticulum; Glycoprotein; Lipoprotein;
KW Membrane; Myristate; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000269|PubMed:25807930"
FT CHAIN 2..250
FT /note="Transmembrane protein 106C"
FT /id="PRO_0000243900"
FT TRANSMEM 87..107
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 197..217
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT LIPID 2
FT /note="N-myristoyl glycine"
FT /evidence="ECO:0000269|PubMed:25807930"
FT CARBOHYD 173
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 186
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 166..184
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_019483"
FT VARIANT 103
FT /note="V -> F (in dbSNP:rs35000511)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_052338"
FT VARIANT 175
FT /note="S -> F (in dbSNP:rs2286025)"
FT /id="VAR_026868"
SQ SEQUENCE 250 AA; 27875 MW; DD54511ADFA0F280 CRC64;
MGSQHSAAAR PSSCRRKQED DRDGLLAERE QEEAIAQFPY VEFTGRDSIT CLTCQGTGYI
PTEQVNELVA LIPHSDQRLR PQRTKQYVLL SILLCLLASG LVVFFLFPHS VLVDDDGIKV
VKVTFNKQDS LVILTIMATL KIRNSNFYTV AVTSLSSQIQ YMNTVVSTYV TTNVSLIPPR
SEQLVNFTGK AEMGGPFSYV YFFCTVPEIL VHNIVIFMRT SVKISYIGLM TQSSLETHHY
VDCGGNSTAI
//
