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Database: UniProt
Entry: T1CSR3_9HELI
LinkDB: T1CSR3_9HELI
Original site: T1CSR3_9HELI 
ID   T1CSR3_9HELI            Unreviewed;       194 AA.
AC   T1CSR3;
DT   16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT   16-OCT-2013, sequence version 1.
DT   08-MAY-2019, entry version 27.
DE   RecName: Full=Thymidylate kinase {ECO:0000256|HAMAP-Rule:MF_00165};
DE            EC=2.7.4.9 {ECO:0000256|HAMAP-Rule:MF_00165};
DE   AltName: Full=dTMP kinase {ECO:0000256|HAMAP-Rule:MF_00165};
GN   Name=tmk {ECO:0000256|HAMAP-Rule:MF_00165};
GN   ORFNames=HFN_1114 {ECO:0000313|EMBL:GAD19874.1};
OS   Helicobacter fennelliae MRY12-0050.
OC   Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC   Helicobacteraceae; Helicobacter.
OX   NCBI_TaxID=1325130 {ECO:0000313|EMBL:GAD19874.1, ECO:0000313|Proteomes:UP000018143};
RN   [1] {ECO:0000313|EMBL:GAD19874.1, ECO:0000313|Proteomes:UP000018143}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MRY12-0050 {ECO:0000313|EMBL:GAD19874.1,
RC   ECO:0000313|Proteomes:UP000018143};
RA   Rimbara E., Matsui M., Mori S., Suzuki S., Suzuki M., Kim H.,
RA   Sekizuka T., Kuroda M., Shibayama K.;
RT   "Draft Genome Sequence of Helicobacter fennelliae Strain MRY12-0050,
RT   Isolated from a Bacteremia Patient.";
RL   Genome Announc. 1:e00512-13(2013).
CC   -!- FUNCTION: Phosphorylation of dTMP to form dTDP in both de novo and
CC       salvage pathways of dTTP synthesis. {ECO:0000256|HAMAP-
CC       Rule:MF_00165}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + dTMP = ADP + dTDP; Xref=Rhea:RHEA:13517,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:58369, ChEBI:CHEBI:63528,
CC         ChEBI:CHEBI:456216; EC=2.7.4.9; Evidence={ECO:0000256|HAMAP-
CC         Rule:MF_00165, ECO:0000256|SAAS:SAAS01114966};
CC   -!- SIMILARITY: Belongs to the thymidylate kinase family.
CC       {ECO:0000256|HAMAP-Rule:MF_00165, ECO:0000256|SAAS:SAAS01070220}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:GAD19874.1}.
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DR   EMBL; BASD01000028; GAD19874.1; -; Genomic_DNA.
DR   RefSeq; WP_023949521.1; NZ_BASD01000028.1.
DR   STRING; 1325130.HFN_1114; -.
DR   EnsemblBacteria; GAD19874; GAD19874; HFN_1114.
DR   OrthoDB; 1585072at2; -.
DR   Proteomes; UP000018143; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004798; F:thymidylate kinase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006233; P:dTDP biosynthetic process; IEA:InterPro.
DR   GO; GO:0006235; P:dTTP biosynthetic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00165; Thymidylate_kinase; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR039430; Thymidylate_kin-like_dom.
DR   InterPro; IPR018094; Thymidylate_kinase.
DR   Pfam; PF02223; Thymidylate_kin; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00041; DTMP_kinase; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00165,
KW   ECO:0000256|SAAS:SAAS01070209};
KW   Complete proteome {ECO:0000313|Proteomes:UP000018143};
KW   Kinase {ECO:0000256|HAMAP-Rule:MF_00165,
KW   ECO:0000256|SAAS:SAAS01070206, ECO:0000313|EMBL:GAD19874.1};
KW   Nucleotide biosynthesis {ECO:0000256|HAMAP-Rule:MF_00165,
KW   ECO:0000256|SAAS:SAAS01070211};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00165,
KW   ECO:0000256|SAAS:SAAS01070205};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018143};
KW   Transferase {ECO:0000256|HAMAP-Rule:MF_00165,
KW   ECO:0000256|SAAS:SAAS01070204, ECO:0000313|EMBL:GAD19874.1}.
FT   DOMAIN        5    186       Thymidylate_kin. {ECO:0000259|Pfam:
FT                                PF02223}.
FT   NP_BIND       7     14       ATP. {ECO:0000256|HAMAP-Rule:MF_00165}.
SQ   SEQUENCE   194 AA;  22068 MW;  C14D5D056974DD2F CRC64;
     MYVVIEGIDT CGKSTQINLL KRHFINAIFT KEPSDSAIGQ FIRTNLELHH KFSARAEFLL
     FLADRAEHID SVIMPNHNSK LIISDRSLIS GIAYVPFDKK DEQELAFVMN VFATSNIMPD
     LCVMLELSES SLKDRLGSKT QDLIEQRGIA YLLDIQEKIK LYAKRLAKHL VIVDASYGRE
     EIQTTIIKEI EKAL
//
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