ID T1D090_9HELI Unreviewed; 738 AA.
AC T1D090;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 24-JAN-2024, entry version 42.
DE RecName: Full=Flagellar biosynthesis protein FlhA {ECO:0000256|RuleBase:RU364093};
GN Name=flhA {ECO:0000256|RuleBase:RU364093};
GN ORFNames=HFN_0835 {ECO:0000313|EMBL:GAD19595.1};
OS Helicobacter fennelliae MRY12-0050.
OC Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC Helicobacteraceae; Helicobacter.
OX NCBI_TaxID=1325130 {ECO:0000313|EMBL:GAD19595.1, ECO:0000313|Proteomes:UP000018143};
RN [1] {ECO:0000313|EMBL:GAD19595.1, ECO:0000313|Proteomes:UP000018143}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MRY12-0050 {ECO:0000313|EMBL:GAD19595.1,
RC ECO:0000313|Proteomes:UP000018143};
RA Rimbara E., Matsui M., Mori S., Suzuki S., Suzuki M., Kim H., Sekizuka T.,
RA Kuroda M., Shibayama K.;
RT "Draft Genome Sequence of Helicobacter fennelliae Strain MRY12-0050,
RT Isolated from a Bacteremia Patient.";
RL Genome Announc. 1:e00512-13(2013).
CC -!- FUNCTION: Required for formation of the rod structure of the flagellar
CC apparatus. Together with FliI and FliH, may constitute the export
CC apparatus of flagellin. {ECO:0000256|RuleBase:RU364093}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU364093};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU364093}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the FHIPEP (flagella/HR/invasion proteins export
CC pore) family. {ECO:0000256|ARBA:ARBA00008835,
CC ECO:0000256|RuleBase:RU364093}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAD19595.1}.
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DR EMBL; BASD01000025; GAD19595.1; -; Genomic_DNA.
DR RefSeq; WP_023949027.1; NZ_BASD01000025.1.
DR AlphaFoldDB; T1D090; -.
DR STRING; 1325130.HFN_0835; -.
DR eggNOG; COG1298; Bacteria.
DR OrthoDB; 9759185at2; -.
DR Proteomes; UP000018143; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0044780; P:bacterial-type flagellum assembly; IEA:InterPro.
DR GO; GO:0009306; P:protein secretion; IEA:InterPro.
DR Gene3D; 3.40.30.60; FHIPEP family, domain 1; 1.
DR Gene3D; 1.10.8.540; FHIPEP family, domain 3; 1.
DR Gene3D; 3.40.50.12790; FHIPEP family, domain 4; 1.
DR InterPro; IPR042194; FHIPEP_1.
DR InterPro; IPR042193; FHIPEP_3.
DR InterPro; IPR042196; FHIPEP_4.
DR InterPro; IPR025505; FHIPEP_CS.
DR InterPro; IPR006301; FlhA.
DR InterPro; IPR001712; T3SS_FHIPEP.
DR NCBIfam; TIGR01398; FlhA; 1.
DR PANTHER; PTHR30161:SF1; FLAGELLAR BIOSYNTHESIS PROTEIN FLHA-RELATED; 1.
DR PANTHER; PTHR30161; FLAGELLAR EXPORT PROTEIN, MEMBRANE FLHA SUBUNIT-RELATED; 1.
DR Pfam; PF00771; FHIPEP; 1.
DR PIRSF; PIRSF005419; FlhA; 1.
DR PRINTS; PR00949; TYPE3IMAPROT.
DR PROSITE; PS00994; FHIPEP; 1.
PE 3: Inferred from homology;
KW Bacterial flagellum biogenesis {ECO:0000256|RuleBase:RU364093};
KW Bacterial flagellum protein export {ECO:0000256|RuleBase:RU364093};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW ECO:0000256|RuleBase:RU364093};
KW Cell projection {ECO:0000313|EMBL:GAD19595.1};
KW Cilium {ECO:0000313|EMBL:GAD19595.1};
KW Flagellum {ECO:0000313|EMBL:GAD19595.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU364093};
KW Protein transport {ECO:0000256|RuleBase:RU364093};
KW Reference proteome {ECO:0000313|Proteomes:UP000018143};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU364093};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU364093}; Transport {ECO:0000256|RuleBase:RU364093}.
FT TRANSMEM 25..43
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364093"
FT TRANSMEM 49..68
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364093"
FT TRANSMEM 80..100
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364093"
FT TRANSMEM 126..145
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364093"
FT TRANSMEM 212..233
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364093"
FT TRANSMEM 245..271
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364093"
FT TRANSMEM 292..312
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364093"
SQ SEQUENCE 738 AA; 81569 MW; 9223F4CBE85406A2 CRC64;
MASKRQSVLK KIAFFLQNIG KSKDLTVVVF LMCILVIIIV PLPPVILDFL LTISIMLSIL
IIFIALYINK PTDFSSFPTL LLIVTLYRLA LNVATTRMIL TQGYLGPESV SDIIAAFGEF
TVGGNYIIGT IIFIILILVN LLVVTNGSTR VTEVRARFAL DAMPGKQMAI DADLNSGLID
EKEARTRRAM LSQEADFYGA MDGASKFVKG DAIASIIITV INIIGGFLIG VFQRDMSIEY
SASTFTILTI GDGLVGQIPA LIIATATGIV ATRTAQQENP KEGFAQNLVS QLTSQSKTLI
IVGVILLLFA SVPGLPTFSL GFVGLLLLFI SWLLSREDKK SLLSIMTDWL NKKFNINLDL
SAESKPESST AADLSPIPKV EKSLEEIKKE EEKNLNEALK IEFLELGLGY ELIGLADIKQ
GGDLIERVRG IRKKIASEYG FLMPQIRIRD NLQLPPSNYE IKLKGVVIGE GSVMSNKFLA
MDTGIVGKEI EGIKTKEPAF GIDALWIDPK DKEDAIINGY TVIDPATVIA THISVLVKNH
AEEFITRDEV KGILDRMAED YPALIEEARK IPALIRLVLQ RLLYEKIPIR DMLSILETTI
DKQAQNMDID TIVECVRAKL ARVITHTFAS DDGVLKILTF APMDEEYLKN RVRISEEYGK
SLDLNAGEAQ KLIDAITSKA NSFLEKGLGH CVLVVDPLLR QPMFRKIQDF RLDVIVLSTA
EIDINSKYEF IGLVEPHF
//
