ID T1ECY0_HELRO Unreviewed; 1225 AA.
AC T1ECY0;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 24-JAN-2024, entry version 51.
DE RecName: Full=Splicing factor 3B subunit 3 {ECO:0000256|ARBA:ARBA00040929};
GN Name=20194432 {ECO:0000313|EnsemblMetazoa:HelroP100012};
GN ORFNames=HELRODRAFT_100012 {ECO:0000313|EMBL:ESO03752.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP100012, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESO03752.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP100012}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the RSE1 family.
CC {ECO:0000256|ARBA:ARBA00038266}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AMQM01004541; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB096590; ESO03752.1; -; Genomic_DNA.
DR RefSeq; XP_009018309.1; XM_009020061.1.
DR AlphaFoldDB; T1ECY0; -.
DR STRING; 6412.T1ECY0; -.
DR EnsemblMetazoa; HelroT100012; HelroP100012; HelroG100012.
DR GeneID; 20194432; -.
DR KEGG; hro:HELRODRAFT_100012; -.
DR CTD; 20194432; -.
DR eggNOG; KOG1898; Eukaryota.
DR HOGENOM; CLU_003246_0_0_1; -.
DR InParanoid; T1ECY0; -.
DR OMA; PRATGHW; -.
DR OrthoDB; 101343at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005686; C:U2 snRNP; IBA:GO_Central.
DR GO; GO:0030620; F:U2 snRNA binding; IBA:GO_Central.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 3.
DR InterPro; IPR004871; Cleavage/polyA-sp_fac_asu_C.
DR InterPro; IPR018846; Cleavage/polyA-sp_fac_asu_N.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR10644; DNA REPAIR/RNA PROCESSING CPSF FAMILY; 1.
DR PANTHER; PTHR10644:SF1; SPLICING FACTOR 3B SUBUNIT 3; 1.
DR Pfam; PF03178; CPSF_A; 1.
DR Pfam; PF10433; MMS1_N; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000015101}.
FT DOMAIN 76..592
FT /note="Cleavage/polyadenylation specificity factor A
FT subunit N-terminal"
FT /evidence="ECO:0000259|Pfam:PF10433"
FT DOMAIN 871..1190
FT /note="Cleavage/polyadenylation specificity factor A
FT subunit C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03178"
SQ SEQUENCE 1225 AA; 135922 MW; 50533F4C5A46D0B1 CRC64;
MHLYNLTLQK ATGVTHVIHG NFSGTKQQEI VVSRGKVLEI LKPDPNTGKV YTLLSEEVFG
VIRSLVPFRL TGGSKDFIVV GSDSGRIVIL EYIPSKNSFE KIHQETYGKS GCRRIVPGQY
LAVDPKGRAI MIGAIEKQKL VYILNRDAQA RLTISSPLEA HKTNTFVYSI VGVDVGFENP
TFACLEIDYE EADSDPTGEA VMKTLQLLTY YELDLGLNHV VRKYSVNLEE HANLLIAVPG
GNEGPSGVLV CSENYITYKN FGDQPDIRCP IPRRRNDLDD PERGMIFVCS ATHRTKTMFF
FLVQTEQGDI FKITLETDED LVTEIRLKYF DTVPVASGMC VLKTGFLFVA SEFGNHNLYQ
IAHLGDDDDE PEFSSAMPLE EGDTFFFAPR PLKNLVMVDE LNSLSPIMGC QITDLGNEDT
PQLYTLCGRG PRSSLRVLRH GLEVSEMAVS ELPGNPNAVW TVKKRTEDEY DSYIIVSFVN
ATLVLSIGET VEEVTDSGFL GTTPTLSCSQ LGDDALVQIY PEGIRHIRSD KRVNEWKTPG
KKSILKCAVN QRQVVIALSG GELVYFEMDP SGQLNEYTER KEMSSEVICM SLARVPPNEQ
RSRFLAVGLS DNTVRIISLD PSDCLSPLSM QALPATPESL CIVELGGSKV GGGSTAEADA
DGKTSSLSSG LFLNIGLQNG VLLRTVLDSV TGDLSDTRTR YLGSRSVKLF KVMMQGTESI
LAMSSRTWLS YTFQNRFHLT PLSYETLEHA SGFASEQCPE GIVAISGNTL RILALEKLGV
VFNQSITPLQ FTPRKLVIHP SSKNIIIIET DHNAYTEETK DARKKQMARE MIEAAGEDEQ
QLACEMAHAF LEENLPEDIF GGAKAGAGMW ASVIRIVNPA NQRTLFKLAL EQNEAAFSIA
LVKFAVRPDE DFLLVGVVRD LVLNPRSVGS GSVHVYKIIS GGEKLELLHK TPVDEVPGAI
MGFKGKVLIG VGRFLRLYEL GKKKLLRKCE NKHIPNFIIN IQAMGFRIVV SDIQESFHFV
KYKRRENQLV IFADDIIPRW LTCACLLDYN TIAGSDKFGN VSVVRLPNET SDDVDEDPTG
NKALWDRGLL SGASQKADTL VNFHIGEMVT SLQKTTLIPG GSEALVYTTL SGSIGMLVPF
TSHEDHDFFQ HLEMHMRSEM VALIGREHLA YRSYFYPVRN VIDGDLCELY NSLSTTKQKT
IAEDLDRNPN EVSKKLEDIR TRYAF
//
