ID T1ED52_HELRO Unreviewed; 534 AA.
AC T1ED52;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE RecName: Full=Amino acid transporter transmembrane domain-containing protein {ECO:0000259|Pfam:PF01490};
GN Name=20194504 {ECO:0000313|EnsemblMetazoa:HelroP101525};
GN ORFNames=HELRODRAFT_101525 {ECO:0000313|EMBL:ESN99538.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP101525, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESN99538.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP101525}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the TMEM104 family.
CC {ECO:0000256|ARBA:ARBA00038166}.
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DR EMBL; AMQM01005804; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB097106; ESN99538.1; -; Genomic_DNA.
DR RefSeq; XP_009022308.1; XM_009024060.1.
DR AlphaFoldDB; T1ED52; -.
DR EnsemblMetazoa; HelroT101525; HelroP101525; HelroG101525.
DR GeneID; 20194504; -.
DR KEGG; hro:HELRODRAFT_101525; -.
DR CTD; 20194504; -.
DR eggNOG; KOG3832; Eukaryota.
DR HOGENOM; CLU_025541_1_0_1; -.
DR InParanoid; T1ED52; -.
DR OMA; RWLAFTI; -.
DR OrthoDB; 67984at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR InterPro; IPR013057; AA_transpt_TM.
DR PANTHER; PTHR16189:SF0; TRANSMEMBRANE PROTEIN 104; 1.
DR PANTHER; PTHR16189; UNCHARACTERIZED; 1.
DR Pfam; PF01490; Aa_trans; 2.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000015101};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 15..36
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 42..67
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 151..170
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 220..240
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 252..270
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 285..303
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 324..346
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 376..401
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 422..442
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 448..473
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 494..518
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 16..70
FT /note="Amino acid transporter transmembrane"
FT /evidence="ECO:0000259|Pfam:PF01490"
FT DOMAIN 137..511
FT /note="Amino acid transporter transmembrane"
FT /evidence="ECO:0000259|Pfam:PF01490"
SQ SEQUENCE 534 AA; 60403 MW; 029DA31F65F33B12 CRC64;
MDAQRSIVRK KHVEYSPMIG MVFLFNLIVG TGALALPKSF SMAGWGVSLV MIIVVAFLSY
VTATYVIETM ACANALLKVE ILKKNEDHRS GAQYSSDIEP GEQIQQTDTV DESTALLRVS
DESRLDLFEI QEVIEMGSMA KIFFNKVGYN LFYLCIAVYL FGDLAIYAAA VPKTLRDVTC
TFYPNVTDGN HSLTNITNLC PTLKNDDPCW IDTTLTRIDI YRIYVACFIF LLGSFVFFNL
QKTKYLQVAT SVMRWIAFFT MVILTIQKLA KGKGKGHPTV ASPMYIPNLF GICVYSFMCH
HSLPQMITPI NNKSSLFKLF AGNYFSVFLF YCLLAFTGIF CFSNVYDLYT LNFQPPKCPN
AAQTDDTITT FPVIQYFLAL FPVFTISTSF PIIGITLRNN LKHMFGFIEK DARARMPTWQ
KFIDRLVFPT VVLLIPFAIA MVTSDIQFLV GITGSYAGNF IQYIVPASLV LMARRRMTSI
RIDDIAKFKS PFKHFAWVCL VFSWSIICFI VVTINNILLL KSSGKPKTNF LQIF
//
