ID T1ED59_HELRO Unreviewed; 1087 AA.
AC T1ED59;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=DZF domain-containing protein {ECO:0000259|PROSITE:PS51703};
GN Name=20194511 {ECO:0000313|EnsemblMetazoa:HelroP101626};
GN ORFNames=HELRODRAFT_101626 {ECO:0000313|EMBL:ESN98446.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP101626, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESN98446.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP101626}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
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DR EMBL; AMQM01005876; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB097144; ESN98446.1; -; Genomic_DNA.
DR RefSeq; XP_009023403.1; XM_009025155.1.
DR AlphaFoldDB; T1ED59; -.
DR STRING; 6412.T1ED59; -.
DR EnsemblMetazoa; HelroT101626; HelroP101626; HelroG101626.
DR GeneID; 20194511; -.
DR KEGG; hro:HELRODRAFT_101626; -.
DR CTD; 20194511; -.
DR eggNOG; KOG3792; Eukaryota.
DR HOGENOM; CLU_285174_0_0_1; -.
DR InParanoid; T1ED59; -.
DR OrthoDB; 4565640at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003725; F:double-stranded RNA binding; IBA:GO_Central.
DR GO; GO:0003727; F:single-stranded RNA binding; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR Gene3D; 1.10.1410.40; -; 1.
DR Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 2.
DR InterPro; IPR006561; DZF_dom.
DR InterPro; IPR049402; DZF_dom_C.
DR InterPro; IPR049401; DZF_dom_N.
DR InterPro; IPR003604; Matrin/U1-like-C_Znf_C2H2.
DR InterPro; IPR043519; NT_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR45762; ZINC FINGER RNA-BINDING PROTEIN; 1.
DR PANTHER; PTHR45762:SF19; ZINC-FINGER PROTEIN AT 72D, ISOFORM B; 1.
DR Pfam; PF20965; DZF_C; 1.
DR Pfam; PF07528; DZF_N; 1.
DR Pfam; PF12874; zf-met; 2.
DR SMART; SM00572; DZF; 1.
DR SMART; SM00355; ZnF_C2H2; 3.
DR SMART; SM00451; ZnF_U1; 3.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 3.
DR PROSITE; PS51703; DZF; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000015101}.
FT DOMAIN 490..1087
FT /note="DZF"
FT /evidence="ECO:0000259|PROSITE:PS51703"
FT REGION 143..165
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 301..350
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 422..441
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 634..724
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 754..783
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 828..849
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 301..322
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 643..692
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 693..707
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 708..724
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1087 AA; 118654 MW; E4EAFFF3F0CF1A84 CRC64;
MDPNAWNYGY YGGTLDHYNI YPTQYPPQAL YPANYQQIPV AAPTPNYGPY GTLIASPVSQ
NVSAKGHMPT YSTDTAHLMK QQPLFKQDGS QKTVNHLKIE TAVGPKEATT STTTTGFTYK
GLDDAVYKAA KSYLAEKQHV GSKASGGGGG GVGGGNWSKE RFRSGRGPVI DPNQWKYCEL
CKCTCAGELA YKAHIQGKAH KKKESQGNHA LILSGSKGHM YCQLCDVSCS SSDAYASHIR
GAKHQKILRV QTKMGKNIPD EGTGTTAGSS SASAASSASP AKKVIVCPRI NFVGGQTLNS
TMSSKSVTGA PSTTTTSADP IGPTAPPTYA SAAAGFKRQG SPADEDSNET PVGLEYVLES
MNETNTAIQF YCKLCECSFS DPHAKYVHSK GRRHRLQYKK KVDPTLKVDS VPSYLDRLKG
QWKNKRKGGG GGMTTGGRGM IGRSDMYRQQ AETLKYEKEL LQWQLMKTAT NSGGGMDAIG
GSDSVSGAGR LFPSTYQQHL ATDVDSCFNL AFDNQHMVFK HNSIYPTEHE LSAVQEFVST
CERSLKLVSD ELNKLDNRRI LKGVMRVGLL AKGLLIRDAL QLELVILTSE KPTKKLLLFI
AENMPKLIAT FSTEKYAVEI SPDVTHLKIY VPTVEEDTEQ EQEPTATTTT TNNNNNNIDN
NDNNNNDNSN DNNNNDNNNN NNVGAESNAD SQGRDDTNLK RNDDATDNNN DDDDNNNDKD
GENYIDENGE EMQVIDTASG DDDGADANLE ADYATEDADE NYYNDDGEQE EYDDDGGGCD
GGDYDQMEGE EELADEGSEE MKEEVKKALR TIVCYIFVAP NISDNYKPAK TEKESTTDTK
ATTTSATTAS TATTTTAASV TTLTTTAGTS FLPGLSTDVA VASDQTVDST SSSSAGINDG
NDYIDEPVCA WALTELKRTK WFHNTMIMNE ACTVLIRVLI DFCKRIPTWT PMGQWTLELL
VERCMSLDHN VSPAVGLRRV FEIVSSGIFL RDGWGLLDPL NRPTNRAEGS KDDLSNRVDA
SDHMCTQEKE DVTNSAQHAL RLIAHGQIYK VLGISKLPPP APRPLPSFHH QQDANRIPPL
MKRMRYM
//
