ID T1EDE7_HELRO Unreviewed; 1032 AA.
AC T1EDE7;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=Enhancer of polycomb-like protein {ECO:0000256|RuleBase:RU361124};
GN Name=20194599 {ECO:0000313|EnsemblMetazoa:HelroP103167};
GN ORFNames=HELRODRAFT_103167 {ECO:0000313|EMBL:ESN93811.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP103167, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESN93811.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP103167}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- FUNCTION: Component of the NuA4 histone acetyltransferase complex which
CC is involved in transcriptional activation of selected genes principally
CC by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is
CC also involved in DNA repair. Involved in gene silencing by neighboring
CC heterochromatin, blockage of the silencing spreading along the
CC chromosome, and required for cell cycle progression through G2/M.
CC {ECO:0000256|ARBA:ARBA00025513}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU361124}.
CC -!- SIMILARITY: Belongs to the enhancer of polycomb family.
CC {ECO:0000256|ARBA:ARBA00008035, ECO:0000256|RuleBase:RU361124}.
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DR EMBL; AMQM01007209; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB097587; ESN93811.1; -; Genomic_DNA.
DR RefSeq; XP_009028025.1; XM_009029777.1.
DR AlphaFoldDB; T1EDE7; -.
DR STRING; 6412.T1EDE7; -.
DR EnsemblMetazoa; HelroT103167; HelroP103167; HelroG103167.
DR GeneID; 20194599; -.
DR KEGG; hro:HELRODRAFT_103167; -.
DR CTD; 20194599; -.
DR eggNOG; KOG2261; Eukaryota.
DR HOGENOM; CLU_294104_0_0_1; -.
DR InParanoid; T1EDE7; -.
DR OrthoDB; 5398022at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0035267; C:NuA4 histone acetyltransferase complex; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0032777; C:piccolo histone acetyltransferase complex; IBA:GO_Central.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR024943; Enhancer_polycomb.
DR InterPro; IPR019542; Enhancer_polycomb-like_N.
DR PANTHER; PTHR14898; ENHANCER OF POLYCOMB; 1.
DR PANTHER; PTHR14898:SF0; ENHANCER OF POLYCOMB-LIKE PROTEIN; 1.
DR Pfam; PF10513; EPL1; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU361124};
KW Reference proteome {ECO:0000313|Proteomes:UP000015101};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU361124};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU361124}.
FT DOMAIN 14..158
FT /note="Enhancer of polycomb-like N-terminal"
FT /evidence="ECO:0000259|Pfam:PF10513"
FT REGION 378..438
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 452..487
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 503..527
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 609..664
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 764..826
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 378..413
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 414..438
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 452..468
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 469..487
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 508..527
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 617..640
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 649..664
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1032 AA; 116845 MW; EF3C94C0F485083A CRC64;
MEGVFRMNKL TFRAKALDSN KPLQVFVGDD IPDSTDFVTA NRTVPEMPTG MEKEEETQHH
LQKALISQQS FGLVNRLIIP VPDVKVIDER YKQTYSSRSK FQLPKKFIHV QPSSTDQDVP
DYDMDEEDEE WLMSHPLTNQ KLLNDPIRFE CVMDKLEKSS SHTVISLPEA KALIKEKDDV
IIAIYDYWLT KRLKQQTKLQ HLIKLERKEL AATAAASSST SAATTSTTLL SSSCIGGGGS
SGSSISNVHS INPYVAFRKR AERMQTRKNR KNDEQSYLKM LKVKDGLLKT MSLLKMLRQR
EILKKAQVQI KSDLFIKRYE QSDWSGSQLE EAIQKFKSTR PVSRPITIQS TNSYTSSNNR
CHNNNNLIYN ETYGPNIYHN DVNNSNNNNF HKNNSNNNNV QSHRPQKNQK SQKNYLKSTH
KKHYHTHHHG HYHHHLHRHT FARNTTDNDI HLSDNDSKND DDDDYVCDRN NNNNNNNNNN
NNSTADKGDV ITLTKSLTLF PTSVMDSRQD DDDDDDVNVD DDFTGDDNDE ASMDGRFAFR
RKKGCLYYDV IPFLSFHFSA NDHSSTDNTV FSRCPRQQRN QNFSLVSIDE SHRRIGQLRQ
RIGRGGRVIW DRSPYEPNEW QSHQPPHRHQ PQNQQQQPHR PHVYTRHKQV RSTGNDDVSG
HHNSLKREGF LNSDVMDSNF CFSTFLDDYT SDDCNVKVED VEVDVVSDDK TFFSNFEDGS
ISTSDDNCSN MSSLNVITSS SSSSRTARGQ QSCSSFLKRK CTSRTGSADS GISSPSLPAS
SVSPSLSTYL PQSSSLSSSS STSSSSTLSS SSSSSSSSSS SLSNKSSSSS LVTRVAICSD
NKCKTNNNNI ICNHLPRHHH DDNNNNNNYN NNNNNNISGD INNTNNDNKF CDITNHTNVD
SSYESLNRPQ FTESKYLKVN NHKRLKIEEE VSSSGGTKNI RTTSMATGRQ IATLSFKNEK
INKVHSNNNS NNINSNNINS NNINSNNINS NNSNHNNKYL LVNDSRYNFI AVVTNEDFLK
KNNETISALD LI
//
