ID T1EDI2_HELRO Unreviewed; 472 AA.
AC T1EDI2;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE RecName: Full=Citrate transporter-like domain-containing protein {ECO:0008006|Google:ProtNLM};
GN Name=20194634 {ECO:0000313|EnsemblMetazoa:HelroP103893};
GN ORFNames=HELRODRAFT_103893 {ECO:0000313|EMBL:ESN92180.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP103893, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESN92180.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP103893}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family.
CC NADC subfamily. {ECO:0000256|ARBA:ARBA00006772}.
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DR EMBL; AMQM01007726; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB097661; ESN92180.1; -; Genomic_DNA.
DR RefSeq; XP_009029686.1; XM_009031438.1.
DR AlphaFoldDB; T1EDI2; -.
DR EnsemblMetazoa; HelroT103893; HelroP103893; HelroG103893.
DR GeneID; 20194634; -.
DR KEGG; hro:HELRODRAFT_103893; -.
DR CTD; 20194634; -.
DR eggNOG; KOG1281; Eukaryota.
DR HOGENOM; CLU_005170_9_1_1; -.
DR InParanoid; T1EDI2; -.
DR OMA; CICIAAN; -.
DR OrthoDB; 1359392at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015556; F:C4-dicarboxylate transmembrane transporter activity; IEA:UniProt.
DR GO; GO:0005310; F:dicarboxylic acid transmembrane transporter activity; IEA:UniProt.
DR GO; GO:1901702; F:salt transmembrane transporter activity; IEA:UniProt.
DR CDD; cd01115; SLC13_permease; 1.
DR InterPro; IPR001898; SLC13A/DASS.
DR PANTHER; PTHR10283:SF82; PROTEIN I'M NOT DEAD YET-RELATED; 1.
DR PANTHER; PTHR10283; SOLUTE CARRIER FAMILY 13 MEMBER; 1.
DR Pfam; PF00939; Na_sulph_symp; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000015101};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..30
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 42..59
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 79..96
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 161..183
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 203..226
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 258..277
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 289..314
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 389..419
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 431..450
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 472 AA; 52667 MW; 550724A1DAF1018D CRC64;
MIVYWMTEVI PMAVTALIPI VLFPWLGVMD SKDICINYLK DANMLFFGGL LVAVAVEKWN
LHKRVALRVL MLVGSKPKWI IFGFMVVTAF LSMWLNNTAT TAMMMPIAQA VLTELDDNRK
KQLEIKRTES RVKMAATLAS MTPEEVDSQK KFSLFRTALK LSIPFASSIG GTGTLIGCGP
NIILKGQMEI LYSTSMINFT SWLVIGMPAM VLDLFFAWVI ILFIFFGFRE TFGRNKVESD
DTANQVIKTE YIKLGKMTFA EMVVGASFLV LAFLWVSREP EFVKGWVKYV WLVGWLFVTD
ACVAITICVL LFILPSKFPN YLCFRRRRDA DPPKPAPPIL DWPTANKQMP WSVILLLGGG
FALADACKVS KLSESIGQFL ISLKNLPQVV VSMIMVVCAF VMTQFTSNMA TTTIMIPILA
QISSETCINP LYLMLPVTIA SSFAFILPVG TPPNAIAYSY GDITIVQMVS RC
//
