ID T1EDS0_HELRO Unreviewed; 374 AA.
AC T1EDS0;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=Protein cereblon {ECO:0008006|Google:ProtNLM};
GN Name=20194722 {ECO:0000313|EnsemblMetazoa:HelroP105243};
GN ORFNames=HELRODRAFT_105243 {ECO:0000313|EMBL:ESO12236.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP105243, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESO12236.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP105243}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
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DR EMBL; AMQM01000109; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB095811; ESO12236.1; -; Genomic_DNA.
DR RefSeq; XP_009008956.1; XM_009010708.1.
DR AlphaFoldDB; T1EDS0; -.
DR STRING; 6412.T1EDS0; -.
DR EnsemblMetazoa; HelroT105243; HelroP105243; HelroG105243.
DR GeneID; 20194722; -.
DR KEGG; hro:HELRODRAFT_105243; -.
DR CTD; 20194722; -.
DR eggNOG; KOG1400; Eukaryota.
DR HOGENOM; CLU_025648_1_1_1; -.
DR InParanoid; T1EDS0; -.
DR OMA; AYQMYDS; -.
DR OrthoDB; 2873452at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0031464; C:Cul4A-RING E3 ubiquitin ligase complex; IBA:GO_Central.
DR GO; GO:0016567; P:protein ubiquitination; IBA:GO_Central.
DR CDD; cd15777; CRBN_C_like; 1.
DR Gene3D; 1.20.58.1480; -; 1.
DR Gene3D; 2.30.130.40; LON domain-like; 1.
DR Gene3D; 2.170.150.20; Peptide methionine sulfoxide reductase; 1.
DR InterPro; IPR034750; CULT.
DR InterPro; IPR003111; Lon_prtase_N.
DR InterPro; IPR046336; Lon_prtase_N_sf.
DR InterPro; IPR015947; PUA-like_sf.
DR PANTHER; PTHR14255; CEREBLON; 1.
DR PANTHER; PTHR14255:SF4; PROTEIN CEREBLON; 1.
DR Pfam; PF02190; LON_substr_bdg; 1.
DR SMART; SM00464; LON; 1.
DR SUPFAM; SSF88697; PUA domain-like; 1.
DR PROSITE; PS51788; CULT; 1.
DR PROSITE; PS51787; LON_N; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000015101};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 75..309
FT /note="Lon N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51787"
FT DOMAIN 310..374
FT /note="CULT"
FT /evidence="ECO:0000259|PROSITE:PS51788"
SQ SEQUENCE 374 AA; 42285 MW; C0BC33468C5CDCF2 CRC64;
MQRIAKFLKK KCFVRSSDSG HRLIDDDGEL DANFNGLHGI ITFDVTLPTA HSYLSDDWQE
VSGRTFHEDG MILHIPILTL PGVVLMPGQM LPLHLFSNSD IAMIKHCLDR DKTFSANNNR
TQKLACVGTT AEILAVKEED SMVMKVKTIG RQRFEVLDTR LDIGGIIIAR VKILPDIELP
DLLQPICPSS LLKHTQQYSD HCKYDFSTNT NQAVINSIPK ANKFHASILT QWPSWVYDQY
NCEKLMMQIR DELQNWNESF DLDKVPTDPA NFSYWVASTL PLDDYMRLEL LRIDCPQQRL
RCELTIMKKC TVMCCKGCGQ SVAELTNVFS MSLEGPLGTY VNPGGHVHET LTVYHANNLS
TVGRPSTESS WFPG
//
