ID T1EE48_HELRO Unreviewed; 340 AA.
AC T1EE48;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE RecName: Full=RWD domain-containing protein {ECO:0000259|PROSITE:PS50908};
GN Name=20194850 {ECO:0000313|EnsemblMetazoa:HelroP106777};
GN ORFNames=HELRODRAFT_106777 {ECO:0000313|EMBL:ESO02624.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP106777, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESO02624.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP106777}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the IMPACT family.
CC {ECO:0000256|ARBA:ARBA00007665}.
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DR EMBL; AMQM01000969; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB096742; ESO02624.1; -; Genomic_DNA.
DR RefSeq; XP_009020032.1; XM_009021784.1.
DR AlphaFoldDB; T1EE48; -.
DR STRING; 6412.T1EE48; -.
DR EnsemblMetazoa; HelroT106777; HelroP106777; HelroG106777.
DR GeneID; 20194850; -.
DR KEGG; hro:HELRODRAFT_106777; -.
DR CTD; 20194850; -.
DR eggNOG; KOG3299; Eukaryota.
DR HOGENOM; CLU_045276_1_0_1; -.
DR InParanoid; T1EE48; -.
DR OMA; ELSAPWM; -.
DR OrthoDB; 5483779at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0006446; P:regulation of translational initiation; IBA:GO_Central.
DR Gene3D; 3.30.230.30; Impact, N-terminal domain; 1.
DR Gene3D; 3.10.110.10; Ubiquitin Conjugating Enzyme; 1.
DR InterPro; IPR023582; Impact.
DR InterPro; IPR001498; Impact_N.
DR InterPro; IPR036956; Impact_N_sf.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR006575; RWD_dom.
DR InterPro; IPR016135; UBQ-conjugating_enzyme/RWD.
DR PANTHER; PTHR16301; IMPACT-RELATED; 1.
DR PANTHER; PTHR16301:SF20; PROTEIN IMPACT; 1.
DR Pfam; PF05773; RWD; 1.
DR Pfam; PF01205; UPF0029; 1.
DR SMART; SM00591; RWD; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR SUPFAM; SSF54495; UBC-like; 1.
DR PROSITE; PS50908; RWD; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Neurogenesis {ECO:0000256|ARBA:ARBA00022902};
KW Reference proteome {ECO:0000313|Proteomes:UP000015101};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Stress response {ECO:0000256|ARBA:ARBA00023016};
KW Translation regulation {ECO:0000256|ARBA:ARBA00022845}.
FT DOMAIN 17..120
FT /note="RWD"
FT /evidence="ECO:0000259|PROSITE:PS50908"
FT REGION 125..156
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 314..340
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 340 AA; 39019 MW; F7B0E988FCE86360 CRC64;
MEKMSCKKSE NLIKQDEEIL TLGAIYSSQF TPGRRNKRKF RLTFKEVSAT SNTFSLVLKI
ELPPEYPSHA PPIYNIDASW LNHRELDKLK KMLTDIYCEN IGENVIHIWL ERIQKFLKDI
INPDTTEKTT KNTGKSSKNF EKRAGNSLEK NAGGRADCEN ECDFKYQPYV PNLQEAPETK
PEDVLPTIHH GQSIIDRKSE FQGHLASICH QKQVQMVVNK LKENNKINSA KHNIVAYRLE
TGDGKVIADS FDDGEHQAGG RMLHVLEQMD ARNVMVVVTR WFGNILLGPD RFKHINSCTR
DILEEHGYLQ HKLPKRTKKS PQTVTAVIDP TKNQKKKSKR
//
