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Database: UniProt
Entry: T1EED8_HELRO
LinkDB: T1EED8_HELRO
Original site: T1EED8_HELRO 
ID   T1EED8_HELRO            Unreviewed;       540 AA.
AC   T1EED8;
DT   16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT   16-OCT-2013, sequence version 1.
DT   08-MAY-2019, entry version 33.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:ESN94674.1, ECO:0000313|EnsemblMetazoa:HelroP107917};
GN   Name=20194940 {ECO:0000313|EnsemblMetazoa:HelroP107917};
GN   ORFNames=HELRODRAFT_107917 {ECO:0000313|EMBL:ESN94674.1};
OS   Helobdella robusta (Californian leech).
OC   Eukaryota; Metazoa; Lophotrochozoa; Annelida; Clitellata; Hirudinea;
OC   Hirudinida; Glossiphoniiformes; Glossiphoniidae; Helobdella.
OX   NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP107917, ECO:0000313|Proteomes:UP000015101};
RN   [1] {ECO:0000313|EnsemblMetazoa:HelroP107917, ECO:0000313|Proteomes:UP000015101}
RP   NUCLEOTIDE SEQUENCE.
RA   Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA   Otillar R.P., Terry A.Y., Boore J.L., Simakov O., Marletaz F.,
RA   Cho S.-J., Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T.,
RA   Lv J., Arendt D., Savage R., Osoegawa K., de Jong P., Lindberg D.R.,
RA   Seaver E.C., Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL   Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ESN94674.1, ECO:0000313|EnsemblMetazoa:HelroP107917, ECO:0000313|Proteomes:UP000015101}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=23254933; DOI=10.1038/nature11696;
RA   Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA   Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA   Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H.,
RA   Aerts A., Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V.,
RA   Lindberg D.R., Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT   "Insights into bilaterian evolution from three spiralian genomes.";
RL   Nature 493:526-531(2013).
RN   [3] {ECO:0000313|EnsemblMetazoa:HelroP107917}
RP   IDENTIFICATION.
RG   EnsemblMetazoa;
RL   Submitted (JUN-2015) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003822};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003822}.
CC   -!- SIMILARITY: Belongs to the inward rectifier-type potassium channel
CC       (TC 1.A.2.1) family. {ECO:0000256|RuleBase:RU003822,
CC       ECO:0000256|SAAS:SAAS00549381}.
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DR   EMBL; AMQM01001710; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KB097571; ESN94674.1; -; Genomic_DNA.
DR   RefSeq; XP_009027712.1; XM_009029464.1.
DR   STRING; 6412.HelroP107917; -.
DR   EnsemblMetazoa; HelroT107917; HelroP107917; HelroG107917.
DR   GeneID; 20194940; -.
DR   KEGG; hro:HELRODRAFT_107917; -.
DR   CTD; 20194940; -.
DR   OrthoDB; 956263at2759; -.
DR   Proteomes; UP000015101; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005242; F:inward rectifier potassium channel activity; IBA:GO_Central.
DR   GO; GO:1990573; P:potassium ion import across plasma membrane; IBA:GO_Central.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.1400; -; 1.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR041647; IRK_C.
DR   InterPro; IPR016449; K_chnl_inward-rec_Kir.
DR   InterPro; IPR013518; K_chnl_inward-rec_Kir_cyto.
DR   InterPro; IPR040445; Kir_TM.
DR   PANTHER; PTHR11767; PTHR11767; 1.
DR   Pfam; PF01007; IRK; 1.
DR   Pfam; PF17655; IRK_C; 1.
DR   PRINTS; PR01320; KIRCHANNEL.
DR   SUPFAM; SSF81296; SSF81296; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000015101};
KW   Ion channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434609};
KW   Ion transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434639};
KW   Membrane {ECO:0000256|SAAS:SAAS00434581, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434575};
KW   Potassium transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434641};
KW   Reference proteome {ECO:0000313|Proteomes:UP000015101};
KW   Transmembrane {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434543, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00036756,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00036755};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00048561}.
FT   TRANSMEM    238    259       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    306    330       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      201    336       IRK. {ECO:0000259|Pfam:PF01007}.
FT   DOMAIN      343    504       IRK_C. {ECO:0000259|Pfam:PF17655}.
SQ   SEQUENCE   540 AA;  62053 MW;  494C61FD338EDBF6 CRC64;
     MEERLTEKVI HRKASRGSDC HIEINESQID GNNNKLITDI EETAEVGSTH DTDEAEECRD
     NIKATFLRKL PAKANKSLPK QVACEAREDA VNKFRYQRFR SDSELITIYP SYSENTLERP
     RKHYWKNPDP IKINCNPKYV RYPSQWSRRE SLPIPSNNSP NLNEYDVAQR KRRTSTYLSN
     WDASLAKYGR SVGRSKKLRL IQQSGECNVQ FSNVHKRSLR YLNDIFTTFL ELPWRYNIFI
     FLFIFVTSWI VFAMCWWTLH EISDLDANNV SCVAGVDSFK TALLFSIETQ QTIGYGTRAI
     NDRCEFGFLL LMLQSVFGAV TQCLVTGIIF SKLARPNRRA ETVIFSKKAV ICSGGNGDST
     LNLEFRLGDM RNSQLIGIAM KAVVVRKTFL ENGKYVTLCQ KRMQLCTESD DDFYYLAWPI
     RVIHKIDDCS PFWGATQDQI SHAEFEILIV LEASCEATGS TVQVKTSYLP SEIDYGFKLA
     PLFTRTKLNG QYKVDYSKFH ETIPDDNMPK TDPRISKRNY IMANSLMTNG SLPSFEDEKS
//
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