ID T1EEE0_HELRO Unreviewed; 459 AA.
AC T1EEE0;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=C2H2-type domain-containing protein {ECO:0000259|PROSITE:PS50157};
GN Name=20194942 {ECO:0000313|EnsemblMetazoa:HelroP107927};
GN ORFNames=HELRODRAFT_107927 {ECO:0000313|EMBL:ESN94682.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP107927, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESN94682.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP107927}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
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DR EMBL; AMQM01001711; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB097571; ESN94682.1; -; Genomic_DNA.
DR RefSeq; XP_009027718.1; XM_009029470.1.
DR AlphaFoldDB; T1EEE0; -.
DR STRING; 6412.T1EEE0; -.
DR EnsemblMetazoa; HelroT107927; HelroP107927; HelroG107927.
DR GeneID; 20194942; -.
DR KEGG; hro:HELRODRAFT_107927; -.
DR CTD; 20194942; -.
DR eggNOG; KOG1721; Eukaryota.
DR HOGENOM; CLU_002678_0_2_1; -.
DR InParanoid; T1EEE0; -.
DR OMA; KITESGM; -.
DR OrthoDB; 2935922at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 10.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR24404:SF49; RH47711P-RELATED; 1.
DR PANTHER; PTHR24404; ZINC FINGER PROTEIN; 1.
DR Pfam; PF00096; zf-C2H2; 4.
DR Pfam; PF13912; zf-C2H2_6; 2.
DR SMART; SM00355; ZnF_C2H2; 13.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 9.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 11.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 13.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000015101};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00042}.
FT DOMAIN 41..63
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 81..108
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 109..136
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 137..164
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 166..193
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 194..221
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 247..276
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 277..304
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 305..332
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 333..361
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 360..388
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 389..416
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 423..451
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
SQ SEQUENCE 459 AA; 54895 MW; AD85682AC9387C19 CRC64;
MYKFELEKCY RPIYFCKTCN KVFSKEEYDG HKAVERNEKP FKCEVCSHLY SNRADLQDHL
DTHDNIIKLK GSEGGRVRQC YVCTKCNRHF DRANYYDEHK ITESGMRPFN CPLCSQSFSR
TRNMINHMLL HRERNQHMCA MCGESFKHRQ DLILHEKSHG GEEIKFYCMQ CNKTFTRASV
YEEHLRVHTG VRPFCCEICG KTFLRESNLC GHMVTHREKQ KLICKRKFAI KQKLLLHELE
HDREEPFKCT ICPMSQPYKF MREYEDHMRI HTGHKPFCCE LCGKTFHRAK NLSTHRYAHV
KEKKFKCEVC GRAFALGTRL KMHLRIHTGE KPYECDICHE KFIRRNDYMD HRRHKHTGGN
TCLYCGKKYS KLESMREHIN DVHRNIKPIK CKLCQESFSY SVALYRHMKK HKGQDKDLNK
KIHHCKFCTK SFPRPCLLDR HMWKAHTSSE SRVVKSEDE
//
