ID T1EEX1_HELRO Unreviewed; 952 AA.
AC T1EEX1;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=Vacuolar protein sorting-associated protein 18 homolog {ECO:0000256|ARBA:ARBA00017338};
GN Name=20195123 {ECO:0000313|EnsemblMetazoa:HelroP109889};
GN ORFNames=HELRODRAFT_109889 {ECO:0000313|EMBL:ESO08844.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP109889, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESO08844.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP109889}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Late endosome membrane
CC {ECO:0000256|ARBA:ARBA00004492}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004492}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004492}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
CC -!- SIMILARITY: Belongs to the VPS18 family.
CC {ECO:0000256|ARBA:ARBA00010454}.
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DR EMBL; AMQM01003081; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB096023; ESO08844.1; -; Genomic_DNA.
DR RefSeq; XP_009012866.1; XM_009014618.1.
DR AlphaFoldDB; T1EEX1; -.
DR STRING; 6412.T1EEX1; -.
DR EnsemblMetazoa; HelroT109889; HelroP109889; HelroG109889.
DR GeneID; 20195123; -.
DR KEGG; hro:HELRODRAFT_109889; -.
DR CTD; 20195123; -.
DR eggNOG; KOG2034; Eukaryota.
DR HOGENOM; CLU_003488_1_0_1; -.
DR InParanoid; T1EEX1; -.
DR OMA; WIQREKW; -.
DR OrthoDB; 22879at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0005768; C:endosome; IBA:GO_Central.
DR GO; GO:0030897; C:HOPS complex; IBA:GO_Central.
DR GO; GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0030674; F:protein-macromolecule adaptor activity; IBA:GO_Central.
DR GO; GO:0007032; P:endosome organization; IBA:GO_Central.
DR GO; GO:0008333; P:endosome to lysosome transport; IBA:GO_Central.
DR GO; GO:0006886; P:intracellular protein transport; IEA:UniProtKB-UniRule.
DR GO; GO:0007040; P:lysosome organization; IBA:GO_Central.
DR GO; GO:0048284; P:organelle fusion; IBA:GO_Central.
DR GO; GO:0006904; P:vesicle docking involved in exocytosis; IBA:GO_Central.
DR InterPro; IPR000547; Clathrin_H-chain/VPS_repeat.
DR InterPro; IPR007810; Pep3_Vps18.
DR InterPro; IPR019453; VPS39/TGF_beta_rcpt-assoc_2.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR23323; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN; 1.
DR PANTHER; PTHR23323:SF26; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 18 HOMOLOG; 1.
DR Pfam; PF05131; Pep3_Vps18; 1.
DR Pfam; PF10367; Vps39_2; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50236; CHCR; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000015101};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT TRANSMEM 465..486
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 14..415
FT /note="Pep3/Vps18/deep orange beta-propeller"
FT /evidence="ECO:0000259|Pfam:PF05131"
FT DOMAIN 766..865
FT /note="Vacuolar sorting protein 39/Transforming growth
FT factor beta receptor-associated"
FT /evidence="ECO:0000259|Pfam:PF10367"
FT COILED 795..829
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 952 AA; 109876 MW; CE293BC060BAEF5A CRC64;
MEVMLKKNDS KSAPMFNRQR ITFDPPDPIK CVCVCNNQLI MALSKNTLIR IDLDRPPSTD
EVELTKIQND SVENMFMDPT GSHVIIAMSS TDNIYLPKNS RKPRVLTKLK GHKITSVAWN
VKQQTEATTG LILVGTSKGV LFELELLSGE SNKLFGQNFE TYTKELCTFV RDKANDVTGL
FFSELPQKKS DNNTGNKMYF VIVTVVSRLY QLVGPMTSQS SEGGPSFSCF FDNYSGRFQD
FPCAKSCSQL SVYSTNHNNP PQRIAWLMDG DVYTGRINMA ASPGMDDVIK DTKLIPYGPD
SKKPIPISMA ITQFHFLILL PNSLRVICLL NENLVEQDAY DGKFGALKGV TMDPIKRIIW
SFSSRAIFKY NVVDENRDIW KIYMNMGEFN LAKQYCKDND DHYDEIVNKE ADHLFISGRY
DECALAFAKS NRSFEEATLK FSNLTDKSPL KKFLLTKLDM MGEKVMMMMM MIMVMWVVMV
MMMIIISNDD NEAANKVLFD RMKMEFKRFM ETGRLQTLIR INAQLIYDII NGQGDESDFI
FFASLISDYE RLLRFHIERG QFEQALNVLS KQQVSKDIIY HYSPYLIHHI PSKTIDFWIS
KGSQLEPRSL LPSLVQYEKN SHYSKNNDSI RYIEYCIDRQ HCRDRSVHNY LVSLYAKYNM
EDRLMGYLLD QGDDPDAVCY DLKYALRVSS EHGLYRTCIH IFTTMRLFDE AVDLALMTDV
ELASQTATIP DDDDELRRKL WLKIARHVVE KEGDIEKTMG VVERGGNLIN IQDVLPLFPD
FVTIDHFKDA ICTSLKNYND EIEEIKKGMD EATDNAQEIR DKMAAFKNRC TKISKSDKCE
SCDFPLTLRD FYVFPCRHAF HMECLLNESW QHLSKHQRNQ ITELQRRIAS LIMEKHQHQL
SPAKTKEMTS LKKEMDALLA SECIYCGTFM IECIDKPFID KDQYDSVVQS WL
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