ID T1EFE2_HELRO Unreviewed; 648 AA.
AC T1EFE2;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE RecName: Full=Glycosyltransferase 25 family member {ECO:0008006|Google:ProtNLM};
GN Name=20195294 {ECO:0000313|EnsemblMetazoa:HelroP111764};
GN ORFNames=HELRODRAFT_111764 {ECO:0000313|EMBL:ESO04768.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP111764, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESO04768.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP111764}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 25 family.
CC {ECO:0000256|ARBA:ARBA00006721}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AMQM01004216; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB096457; ESO04768.1; -; Genomic_DNA.
DR RefSeq; XP_009017347.1; XM_009019099.1.
DR AlphaFoldDB; T1EFE2; -.
DR STRING; 6412.T1EFE2; -.
DR EnsemblMetazoa; HelroT111764; HelroP111764; HelroG111764.
DR GeneID; 20195294; -.
DR KEGG; hro:HELRODRAFT_111764; -.
DR CTD; 20195294; -.
DR eggNOG; KOG4179; Eukaryota.
DR HOGENOM; CLU_024037_2_0_1; -.
DR InParanoid; T1EFE2; -.
DR OMA; QRVYHYV; -.
DR OrthoDB; 5490945at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0050211; F:procollagen galactosyltransferase activity; IBA:GO_Central.
DR CDD; cd06532; Glyco_transf_25; 1.
DR InterPro; IPR002654; Glyco_trans_25.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR PANTHER; PTHR10730:SF53; GLYCOSYLTRANSFERASE 25 FAMILY MEMBER; 1.
DR PANTHER; PTHR10730; PROCOLLAGEN-LYSINE,2-OXOGLUTARATE 5-DIOXYGENASE/GLYCOSYLTRANSFERASE 25 FAMILY MEMBER; 1.
DR Pfam; PF03452; Anp1; 1.
DR Pfam; PF01755; Glyco_transf_25; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000015101};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 25..46
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 597..627
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 605..625
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 648 AA; 75007 MW; F9AB1B3F0A2D80D0 CRC64;
MSDLNCFLEK IKVLPHQKSQ ANSKAVGLFF TSSIFIIISL ILIGLLPTTC QSAEEIWPAS
STAPSVMIAI LLRNKAHTLP WFLHYLEKLD YPKNRIRLWL EIDHNVDNSV SMMKKWLGRV
QSQYNKVDFV DDDSEINYPD AYGPYHWSKK RVSNILRLRQ EALNSARNTW TDFLLFVDAD
NFLLNDQVLK ELMRHDKPII SPMMNVTASD YYSNFWGDVA PNGYYKRSDD YEDILHKVKT
GAFQVPVVHS TMLIQTRLQI TNSLAYDPPP PNYEGPIDDI IIFAFSARYH KVPMYILNEN
FYGMMLIPLG DEDTIEDEKE QFLHMKLQAI VDDVTLEKLP YLDAPARPPD KLGFDEIFMI
NLVRRPERRD KMIRCFKELG INATIFDAVD GKQLNDSFLN SWNVKVLKSY ADPYHGTRTL
TMGEIGCFLS HYFIWLQVVN RNLSKVIIFE DDVRFSRDFR GKLKAVMSDI DKMEIPWDLL
YLGRKKLFED GEPFVGDSET LVWPLYSYWT IGYALSYAGA FKLVHEDPLP KMVPVDEYLP
IMFDNHPRED WQEHFENRNL VALSTFPLLI EPTLYTGEPG YFTDTEDSPT VDVVVPEVGP
NAPFDTNHPD SNENDSNNNN QCANMDKLKG DMDWIDDVRQ SLESKNEL
//
