ID T1EFG8_HELRO Unreviewed; 378 AA.
AC T1EFG8;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE RecName: Full=C2H2-type domain-containing protein {ECO:0000259|PROSITE:PS50157};
GN Name=20195320 {ECO:0000313|EnsemblMetazoa:HelroP112077};
GN ORFNames=HELRODRAFT_112077 {ECO:0000313|EMBL:ESO03665.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP112077, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESO03665.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP112077}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
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DR EMBL; AMQM01004527; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB096590; ESO03665.1; -; Genomic_DNA.
DR RefSeq; XP_009018222.1; XM_009019974.1.
DR AlphaFoldDB; T1EFG8; -.
DR STRING; 6412.T1EFG8; -.
DR EnsemblMetazoa; HelroT112077; HelroP112077; HelroG112077.
DR GeneID; 20195320; -.
DR KEGG; hro:HELRODRAFT_112077; -.
DR CTD; 20195320; -.
DR eggNOG; KOG1721; Eukaryota.
DR HOGENOM; CLU_732116_0_0_1; -.
DR InParanoid; T1EFG8; -.
DR OMA; SHCTIEI; -.
DR OrthoDB; 2936270at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 5.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR46451; RAS-RESPONSIVE ELEMENT-BINDING PROTEIN 1; 1.
DR PANTHER; PTHR46451:SF1; RAS-RESPONSIVE ELEMENT-BINDING PROTEIN 1; 1.
DR Pfam; PF00096; zf-C2H2; 1.
DR Pfam; PF13894; zf-C2H2_4; 1.
DR Pfam; PF13912; zf-C2H2_6; 1.
DR SMART; SM00355; ZnF_C2H2; 6.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 3.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 4.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 5.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00042};
KW Reference proteome {ECO:0000313|Proteomes:UP000015101};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00042};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00042}.
FT DOMAIN 91..118
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 121..148
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 172..199
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 227..254
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 255..282
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT REGION 42..61
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 271..378
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 297..321
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 329..367
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 378 AA; 43280 MW; DC396DF341332BFC CRC64;
MNQKVFMLAL GLNYVPREIA NAENEEPLDL MITDSNANNN CKVDNSLNDN GRDDNQDSDI
TSSSLTSVAT AAAAAATSTS SSRFLPVEKH FSCALCSQWF TTKANCERHL KSSYSDSPHK
LMCCYCPRTF PWASSLGRHL LTHIGEKPYT CDICDVGFST KSNRGRHMLR KHHCQNCGLE
FKCRKVLLRH LKEHNIDLPY KCYLCDASYQ HRIDSLLHKG DYAQRKVFCT FCPKRFWSLQ
DLRRHMRSHT GERPFECDLC SARFTLKHSM MRHRRRHGGP QHPEEEEEEE DETESGSRET
ESGCGENYKD DNEHERLIDY FVNEVAKSQD AAPDDDDAGD NFSQNKETEI GDDDVHYDNR
HHVINLSTTK DSETPLGN
//
