ID T1EFI1_HELRO Unreviewed; 511 AA.
AC T1EFI1;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE RecName: Full=Transmembrane protein 180 {ECO:0008006|Google:ProtNLM};
GN Name=20195333 {ECO:0000313|EnsemblMetazoa:HelroP112249};
GN ORFNames=HELRODRAFT_112249 {ECO:0000313|EMBL:ESO03349.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP112249, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESO03349.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP112249}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
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DR EMBL; AMQM01004634; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB096633; ESO03349.1; -; Genomic_DNA.
DR RefSeq; XP_009018497.1; XM_009020249.1.
DR AlphaFoldDB; T1EFI1; -.
DR STRING; 6412.T1EFI1; -.
DR EnsemblMetazoa; HelroT112249; HelroP112249; HelroG112249.
DR GeneID; 20195333; -.
DR KEGG; hro:HELRODRAFT_112249; -.
DR CTD; 20195333; -.
DR eggNOG; ENOG502QQN2; Eukaryota.
DR HOGENOM; CLU_034985_0_0_1; -.
DR InParanoid; T1EFI1; -.
DR OMA; HINNLYF; -.
DR OrthoDB; 2875056at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR040035; TMEM180.
DR PANTHER; PTHR28658; TRANSMEMBRANE PROTEIN 180; 1.
DR PANTHER; PTHR28658:SF3; TRANSMEMBRANE PROTEIN 180; 1.
DR Pfam; PF13347; MFS_2; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000015101};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 7..28
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 40..63
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 89..105
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 111..128
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 149..171
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 177..198
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 288..307
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 319..346
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 467..487
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 511 AA; 58499 MW; 281DCA410512F7F8 CRC64;
MKNYIALCYG SISFFINILH NIFLIYHVDV FLNVYKIDKT SFWVGEIIFL IWNSLNDPIF
GWISDRKYLS NDHEKNNSFN IIANRLNKLH INGPLLSITF IFFWLSWSFP AIQFVVCLCL
YDGFLTMIDL HHSALLADLS ISTEIRTKLN MHCSVFSALG SMFVFVSYAV WDKDNFFPFQ
KFCFLVAIIA FFGFYASVKL MKNELKHSTI HEKIDELDEA TTATTTLMRD NKDAMKCFIK
QLSGQSNFLW FTAMNLVQVF HCHFNSNFFP MFLTVLLGEK TSPFVCSLLL GVSFIAPHLN
NIYFLILCRK YGAYDVIKYL FILKLSFAIL VFFCGGQNVW LLAFFIASNR IFTEGTCKLL
NLVITDLVDE DVVINQRSNS VSALMFGVVA FLSKPGQTMA PVIGTVLLST FTGRDIFQTR
TNEMRGVKNI DIISLNHQVD DNGNVPNIAH NSDTAYTNQE NSYQDGVFNL LIIVPVMCAI
LQLFFWFNFT LHGKKLSQIK TLRASLKFVS V
//
